The new study finds brain-wide changes in virtually all of the 11 cortical regions analyzed, regardless of whether they are higher critical association regions – those involved in functions such as reasoning, language, social cognition and mental flexibility – or primary sensory regions.
Researchers are working to develop nanocarriers that deliver drugs across the blood brain barrier. Successful nanocarriers could lead to treatments for brain disorders including Alzheimer’s disease, Parkinson’s disease, ischemic stroke, epilepsy and seizures.
Researchers at Tufts University School of Medicine have discovered a previously unknown function performed by a type of cell that comprises nearly half of all cells in the brain.
The scientists say this discovery in mice of a new function by cells known as astrocytes opens a whole new direction for neuroscience research that might one day lead to treatments for many disorders ranging from epilepsy to Alzheimer’s to traumatic brain injury.
Case Western Reserve University researchers studying prions—misfolded proteins that cause lethal incurable diseases—have identified for the first time surface features of human prions responsible for their replication in the brain.
The Hereditary Disease Foundation is hosting a free webinar “What’s It All About? Alfy and Aggregates” on Tuesday, March 23, 2021, from 12pm to 1pm ET. Dr. Ai Yamamoto, associate professor in the departments of Neurology and of Pathology and Cell Biology at Columbia University Vagelos College of Physicians and Surgeons and recipient of the 2020 Leslie Gehry Brenner Prize for Innovation in Science, will be the keynote speaker.
Scientists at the Case Western Reserve University School of Medicine have determined the structure of protein “fibrils” linked to Lou Gehrig’s disease and other neurodegenerative disorders—findings that provide clues to how toxic proteins clump and spread between nerve cells in the brain.
A lack of a protein in the brain that keeps our tissues healthy as we age is linked to Alzheimer’s disease, according to recent research from The University of Texas Health Science Center at Houston (UTHealth).
“There’s no place like home,” has its roots deep in the brain. Using fiber photometry, scientists are the first to show that home evokes a surge of dopamine in mice that mimics the response to a dose of cocaine. The study demonstrates how dopamine rises rapidly in mice moved from a simple recording chamber to their home cage, but less so when they return to a cage not quite like the one they knew.
A grant from the National Institutes of Health will allow a Penn State College of Medicine researcher to lead a three-year, multi-institution project to create an atlas of developing mice brains.