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Tag: PHARMACEUTICAL SCIENCES
UCI researchers discover crucial role of brain’s striatum cilia in time perception
Irvine, Calif., Nov. 30, 2022 — Researchers at the University of California, Irvine have discovered that removal of cilia from the brain’s striatum region impaired time perception and judgment, revealing possible new therapeutic targets for mental and neurological conditions including schizophrenia, Parkinson’s and Huntington’s diseases, autism spectrum disorder, and Tourette syndrome.
UCI-led study shows Rhodiola rosea root might be beneficial for managing type 2 diabetes
A team of researchers led by the University of California, Irvine has discovered that treatment with an extract from the roots of the Rhodiola rosea plant might be effective for helping manage type 2 diabetes, showing promise as a safe and effective non-pharmaceutical alternative. The study, recently published online in Scientific Reports, found that in a mouse model of human type 2 diabetes, Rhodiola rosea lowered fasting blood sugar levels, improved response to insulin injections, modulated the composition of bacteria in the gastrointestinal tract and decreased several biomarkers of inflammation.
Best New Dean of Skaggs School of Pharmacy and Pharmaceutical Science
Brookie Best, PharmD, has been named the next dean of the Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego, succeeding James McKerrow, PhD, MD, who stepped down June 30, 2022.
Pharmacists at Higher Risk of Suicide than General Population, Study Finds
UC San Diego study shows suicide rates were higher in pharmacists than in the general population between 2003 and 2018, with job problems being the most significant feature associated with the suicides.
UCI to welcome inaugural Doctor of Pharmacy class at White Coat Ceremony
Irvine, Calif., Sept. 14, 2021 – The inaugural class of Pharm.D. students at the University of California, Irvine will begin their journey Sept. 24 at a White Coat Ceremony, a rite of passage marking the transition from the study of preclinical to clinical health sciences. The white coat is universally recognized as a symbol of the commitment students are making in joining a trusted health profession.
Chula Virtual International Graduate Open House Academic Year 2021-2022
Join us at our Virtual Graduate Open House (International) to find out about the diverse range of international programs available and the benefits of studying at Chula. Organized by the Office of International Affairs and Global Network (OIA), during August 31 – September 3, 2021, at 1.00 – 4.00 PM (GMT +7) via Zoom webinars and Facebook Live, the event is an ideal way to explore the graduate programs, connect with faculty and staff, get answers to your questions about graduate school, and get details on deadlines, funding, career paths, specific requirements, and much more.
Mount Sinai researchers develop novel therapy that could be effective in many cancers
New York, NY (July 23, 2021) — Mount Sinai researchers have developed a therapeutic agent that shows high effectiveness in vitro at disrupting a biological pathway that helps cancer survive, according to a paper published in Cancer Discovery , a…
Llama ‘nanobodies’ could hold key to preventing deadly post-transplant infection
Scientists have developed a ‘nanobody’ – a small fragment of a llama antibody – that is capable of chasing out human cytomegalovirus (HCMV) as it hides away from the immune system. This then enables immune cells to seek out and…
Characterized drugs show unexpected effects
Known and yet unexpected: many active substances influence the cholesterol homeostasis and thereby possibly a SARS-CoV-2 infection
Geneticists reveal how mutation causes childhood cancer; use drug to reverse its effects
Geneticists from Trinity College Dublin have discovered how a specific genetic mutation called H3K27M causes a devastating, incurable childhood cancer, known as diffuse midline glioma (DMG), and – in lab studies working with model cell types – successfully reverse its…
Precision treatment for severe asthma targets a specific mutation
Drug blocks a cell receptor that is mutated disproportionately in people of color
Toward one drug to treat all coronaviruses
Safe and effective vaccines offer hope for an end to the COVID-19 pandemic. However, the possible emergence of vaccine-resistant SARS-CoV-2 variants, as well as novel coronaviruses, make finding treatments that work against all coronaviruses as important as ever. Now, researchers…
Toxicity testing on the placenta and embryo
Drugs must be safe not just for the patients; in the case of pregnant patients, drugs must also be safe for the unborn children still in the womb. Therefore, at an early stage in the development of new medicines, candidate…
Martin Thornhill named 2021 recipient of the IADR Distinguished Scientist Award in PPT
Alexandria, Va., USA – The International Association for Dental Research (IADR) announced Martin Thornhill, University of Sheffield, England, as the 2021 recipient of the IADR Distinguished Scientist Award in Pharmacology/Therapeutics/Toxicology Research. Thornhill was recognized during the Opening Ceremonies of the…
Dartmouth study explores race inequity in opioid prescribing among US health systems
A new Dartmouth-led study published this month in the New England Journal of Medicine sheds light on the role U.S. health systems play concerning racial inequality in prescription pain medicine receipt. For more than a decade, research has demonstrated that…
Evidence of sustained benefits of pimavanserin for dementia-related psychosis
Evidence of the sustained benefits of an investigational antipsychotic treatment for people with dementia-related psychosis has been published. Up to half of the 45 million people worldwide who are living with Alzheimer’s disease will experience psychotic episodes, a figure that…
New approach eradicates breast cancer in mice
CHAMPAIGN, Ill. — A new approach to treating breast cancer kills 95-100% of cancer cells in mouse models of human estrogen-receptor-positive breast cancers and their metastases in bone, brain, liver and lungs. The newly developed drug, called ErSO, quickly shrinks…
Mark Foundation funds Jackson Laboratory scientists to study immunotherapy side effects
The Mark Foundation for Cancer Research funds Jackson Laboratory scientists to take on immunotherapy’s greatest challenges — improving response rates and decreasing debilitating side effects
New study investigates formation of dangerous compounds by e-cigarettes
Scientists with the Desert Research Institute (DRI) Organic Analytical Laboratory in Reno, Nev., led by Andrey Khlystov, Ph.D., have been awarded a $1.5M grant from the National Institutes of Health (NIH) to study the formation of dangerous compounds by electronic…
SARS-CoV-2: Achilles’ heel of viral RNA
Researchers at Goethe University find small molecules as binding partners for genomic RNA of the coronavirus
Bill Greene, PharmD, of St. Jude receives lifetime achievement award
William L. “Bill” Greene, PharmD, chief pharmaceutical officer, to receive the 2021 Shelby Rhinehart Public Service Lifetime Achievement Award.
A small molecule induces readthrough of cystic fibrosis CFTR nonsense mutations
This research suggests that a path to treat currently untreatable cases of cystic fibrosis is clearly achievable.
Freeze drying, oral health experiments make speedy return from space station aboard SpaceX Dragon
A suite of International Space Station scientific experiments journey back to Earth aboard the 22nd SpaceX commercial resupply services mission for NASA.
Artificial sweeteners enable delivery of carbon monoxide to treat organ injury
ATLANTA–An oral prodrug developed by a team of scientists led by Binghe Wang, Regents’ Professor of Chemistry at Georgia State University, delivers carbon monoxide to protect against acute kidney injury, according to a new paper published in Chemical Science .…
Common COVID-19 antibiotic no more effective than placebo
UCSF outpatient study found limited effect of azithromycin on progression of disease
Silicon in drinking water caused irreversible lung pathologies in rodents
Scientists of Immanuel Kant Baltic Federal University examined the effect of long-term silicon intake on the health of mice and rats.
The virus trap
Hollow nano-objects made of DNA could trap viruses and render them harmless
Measures and clinical approach of COVID 19
The coronavirus disease 2019 (COVID-19) outbreak has spread throughout the globe and much time has passed since it was declared as a pandemic by the World Health Organization (WHO). COVID-19: Diagnosis and Management provides clinicians and scholars all the information…
Present and future application of artificial intelligence in clinical drug
The combination of expert knowledge and multidisciplinary approaches highlighted in the book make it a valuable source of information for physicians and clinical researchers active in the field of cancer diagnosis and treatment (oncologists, oncologic surgeons, radiation oncologists, nuclear medicine…
ISSRDC to feature in-space production applications and its impact on the space economy
KENNEDY SPACE CENTER (FL), July 14, 2021 – The International Space Station Research and Development Conference (ISSRDC) will host multiple sessions focused on in-space production applications during its 10th annual gathering, taking place August 3-5. This year’s event, which will…
Melanoma of the eye: Preclinical tests show path toward treatment
A small molecule inhibitor has been identified that reduces the growth of uveal melanoma, a rare and deadly cancer of the eye
Scientists identify new gut-liver drug recycling process
Implications for developing treatments for intestinal diseases
Microcrystal electron diffraction supports a new drug development pipeline
CAMBRIDGE July 13, 2021 – To date, solving structures of potential therapeutics using X-ray diffraction (XRD) has been an assumed, pivotal step in the drug development process. But a recent paper by a team of researchers led by NanoImaging Services…
Early anticoagulant treatment shown to reduce death in moderately ill COVID-19 patients
International RAPID Trial could contribute to clinical practice
Mechanical stimuli significantly influence organ growth
Organoids help understand the complex interactions of cells and tissue
Scientists blueprint bacterial enzyme believed to “stealthily” suppress immune response
Scientists have produced the first fine-detail molecular blueprints of a bacterial enzyme known as Lit, which is suspected to play a “stealthy” role in the progression of infection by reducing the immune response. Blueprints such as these allow drug designers…
Standigm secures SI investment for expanding its AI-drug development capacity
SK Chemicals-Standigm will collaborate for the development of Standigm’s AI-driven drug candidate
Study Sheds Light on Mechanism of Liposome Accumulation in Tumors
Dmitri Simberg, PhD, associate professor in the University of Colorado Skaggs School of Pharmacy, released a new study of the effectiveness of different types of fluorescent labels used to monitor the accumulation of liposomes in tumors. The study was published on July 1, 2021, in ACS Nano.
Study sheds light on mechanism of liposome accumulation in tumors
CU Cancer Center researcher says results could impact how we diagnose, monitor, and treat tumors with liposomes.
New Alzheimer’s treatment targets identified
Study points to FDA-approved drugs that have potential to slow or reverse brain damage
American Society for Radiation Oncology (ASTRO) to host Annual Meeting in Chicago 10/24-27
#ASTRO21 will be the first major medical conference in the city; a curated digital program also will be offered for remote attendees
Hybrid enzyme catalysts synthesized by a de novo approach for expanding biocatalysis
The two major challenges in industrial enzymatic catalysis are the limited number of chemical reaction types that are catalyzed by enzymes and the instability of enzymes under harsh conditions in industrial catalysis. Expanding enzyme catalysis to a larger substrate scope…
New approach will help identify drugs that can ‘glue’ proteins together
A new screening method that can test the effectiveness of therapeutic molecules designed to ‘glue’ proteins together in the body has been developed by researchers at the University of Birmingham and the University of Leicester. The research paves the way…
Harnessing AI to discover new drugs
Nature has a vast store of medicinal substances. “Over 50 percent of all drugs today are inspired by nature,” says Gisbert Schneider, Professor of Computer-Assisted Drug Design at ETH Zurich. Nevertheless, he is convinced that we have tapped only a…
Mucus and mucins may become the medicine of the future
Many people instinctively associate mucus with something disgusting, but in fact, it has incredibly many valuable functions for our health. It keeps track of our important intestinal flora and feeds the bacteria. It covers all internal surfaces of our body,…
UCI professor receives American College of Clinical Pharmacy award
Joyce Yu-Chia Lee is the first faculty member to earn the prestigious honor
New cancer findings can give wider access to immunotherapy
Researchers at Karolinska Institutet in Sweden publish new findings in the journal Cancer Discovery showing how pharmacological activation of the protein p53 boosts the immune response against tumours. The results can be of significance to the development of new combination…
Comparing spending on common generic drugs by Medicare vs Costco members
What The Study Did: The amount Medicare pays for common generic prescriptions in Part D was compared with prices available to patients without insurance at Costco. Authors: Erin Trish, Ph.D., of the University of Southern California, Los Angeles, is the…
Adult ADHD is linked to numerous physical conditions
Adults with ADHD are at higher risk of a wide range of physical conditions, including nervous system, respiratory, musculoskeletal, and metabolic diseases, according to a large register-based study from Karolinska Institutet in Sweden published in The Lancet Psychiatry . “Identifying…