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UrduRandy D. Blakely, Ph.D., has been named a Fellow of the American Society for Pharmacology and Experimental Therapeutics (ASPET). Designation as an ASPET Fellow recognizes leaders in the field for their exceptional contributions to pharmacological research, education, mentorship and leadership.
Tag: Parkinson’s Disease
UdeM receives $8M to study the link between the immune system and Parkinson’s disease
A team led by Michel Desjardins, a professor in the Faculty of Medicine, has secured $8M from ASAP to study the connection between the immune system and Parkinson’s disease.
Challenging Current Understanding, Study Reveals Rapid Release of Dopamine Not Needed for Initiating Movement
At a glance: Study in mice reveals rapid release of dopamine is not needed for initiating movement but is important for activities related to reward-seeking and motivation. The findings help explain why the widely used Parkinson’s drug levodopa improves movement-related symptoms but often fails to ameliorate some cognitive ones. The work may inform the development of new therapies that restore both slow and fast dopamine action to treat multiple symptoms.
Investigadores crean “minicerebros” para modelar la demencia con cuerpos de Lewy e identificar tratamientos
La demencia con cuerpos de Lewy (DCL) es una enfermedad neurodegenerativa progresiva que comparte características tanto de la enfermedad de Parkinson cuanto de la enfermedad de Alzheimer, pero que puede ser más difícil de diagnosticar. Los síntomas pueden incluir alucinaciones, trastornos del movimiento, problemas cognitivos, problemas para dormir y depresión.
Florida Atlantic University Parkinson’s Expert Available
Dr. Michael R. Dobbs, from Florida Atlantic University Schmidt College of Medicine, comments on Parkinson’s Disease: “It takes a lot of courage for a celebrity to share that they have Parkinson’s disease. By coming forward, they not only reveal their personal…
Penny for Your Thoughts? Master Copper Regulator Discovery May Offer Alzheimer’s Clues
A groundbreaking study using a tiny roundworm could pave the way for new treatments for neurodegenerative disorders. Researchers have linked the worm gene swip-10 to copper regulation – a vital element for brain health found in everyday items like wiring and cookware. Understanding the roles of swip-10 and MBLAC1, a protein involved in processing cellular materials, could lead to the development of effective medications and opens new avenues for advancing brain disease treatments.
Wistar Institute Researchers Identify Parkinson-related Protein’s Role in Cancer and T Cell Activation
Wistar scientists have demonstrated the role of Parkin — a protein implicated in Parkinson’s disease — in the body’s innate immune response to cancer.
New Study Shows that Chronic Neurodegeneration can be Prevented after Traumatic Brain Injury
Violent blows or jolts to the head can cause traumatic brain injury (TBI), and there are currently about five million people in the U.S. living with chronic neurodegeneration and related impairments due to TBI.
Study of ANPD001 Autologous Neuronal Cell Replacement Treatment Approach Published in Journal of Neurosurgery
The Journal of Neurosurgery has published online a study by the Wisconsin National Primate Research Center at the University of Wisconsin, Madison regarding a novel cell transplantation approach being used for delivery of ANPD001, an autologous, dopaminergic neuronal cell replacement under investigation by Aspen Neuroscience as a potential treatment for Parkinson’s Disease.
Does Your Body Composition Affect Your Risk of Dementia or Parkinson’s?
People with high levels of body fat stored in their belly or arms may be more likely to develop diseases like Alzheimer’s and Parkinson’s than people with low levels of fat in these areas, according to a study published in the July 24, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Researchers Find Link between Immune Cell Traits and Parkinson’s Disease
Article title: Genetic causal relationship between multiple immune cell phenotypes and Parkinson’s disease: a two-sample bidirectional Mendelian randomization study Authors: Hong Chen, Xie Wang, Ze Chang, Juan Zhang, Daojun Xie From the authors: “Our study identified a close link between immune cells and…
It’s been 16 Years since sweet-spot brain stimulation slowed Parkinson’s progression for Hermitage man
In 2008 at VUMC there were a group of doctors trying something unheard of on a handful of patients who signed up for their study. Half would receive deep brain stimulation (DBS) surgery in attempt to slow the progression of their early-stage Parkinson’s disease, and the others would not.
Uniformed Services University Contributes to Groundbreaking Global Study on Multiple System Atrophy
In a groundbreaking study published May 2, 2024 in Neuron, researchers have identified four new genetic risk factors for multiple system atrophy (MSA), shedding light on this poorly understood disorder.
Welcome to a world where we can cure blindness, chronic pain and neurological diseases with 3D printed surgical implants
Clever bio-inks that sit inside the human body and restore damaged neurons could cure a whole swathe of diseases in the next 20 years: conditions that have baffled scientists and clinicians for centuries.
Genetic variations may predispose people to Parkinson’s disease following long-term pesticide exposure, study finds
A new UCLA Health study found certain genetic variants could help explain how long-term pesticide exposure could increase the risk of Parkinson’s disease.
Scientists identify cell vulnerability ‘fingerprint’ related to Parkinson’s, Lewy body dementia
A new study offers a first look into the complex molecular changes that occur in brain cells with Lewy bodies, which are key pathological hallmarks of Parkinson’s disease and some dementias.
Researchers Report on the Effectiveness of Skin Biopsy to Detect Parkinson’s and Related Neurodegenerative Diseases
In a paper published in the Journal of the American Medical Association (JAMA), neurologists at Beth Israel Deaconess Medical Center (BIDMC) showed that a simple skin biopsy test detects an abnormal form of alpha-synuclein, the pathological hallmark of Parkinson’s disease and the subgroup of neurodegenerative disorders known as synucleinopathies, at high positivity rates.
Study Shows Differences in How Patients with Impulse Control Disorder Process Consequences
In a new study, published online today in Scientific Reports, researchers found differences in how people with ICD process the consequences of their actions compared to those without ICD, both on and off medication.
Study Finds Pesticide Use Linked to Parkinson’s in Rocky Mountain, Great Plains Region
Pesticides and herbicides used in farming have been linked to Parkinson’s disease in the Rocky Mountain and Great Plains region of the country, according to a preliminary study released today, February 27, 2024, that will be presented at the American Academy of Neurology’s 76th Annual Meeting taking place April 13–18, 2024, in person in Denver and online.
Hackensack Meridian Health, Part of Select Parkinson’s Foundation Study Group, Implementing Changes to Better Care for Patients
Partnership with Parkinson’s Foundation to write protocols for patients hospitalized with Parkinson’s Disease to receive the best care.
Fixing rogue brain cells may hold key to preventing neurodegeneration
A team led by scientists at the Case Western Reserve University School of Medicine has identified a new therapeutic approach for combating neurodegenerative diseases.
Gold nanoparticles reverse brain deficits in multiple sclerosis, Parkinson’s
Results from phase two clinical trials at UT Southwestern Medical Center showed that a suspension of gold nanocrystals taken daily by patients with multiple sclerosis (MS) and Parkinson’s disease (PD) significantly reversed deficits of metabolites linked to energy activity in the brain and resulted in functional improvements.
University Hospitals Selected as Study Site for the Black and African American Connections to Parkinson’s Disease (BLAAC PD) Study
University Hospitals has been selected by the Global Parkinson’s Genetics Program as one of four new study sites for the Black and African American Connections to Parkinson’s Disease (BLAAC PD) study.
Microbial Metabolites: A New Link to Parkinson’s Disease?
Published in Environment International, a groundbreaking study from the Institute of Biological Chemistry and Centre for Microbiology and Environmental Systems Science (CeMESS) at the University of Vienna, in collaboration with the University of Konstanz and the Albert Einstein College of Medicine, reveals a microbial metabolite’s role in inducing Parkinson’s-like symptoms.
Brigham researchers uncover ‘circular logic’ of RNAs in Parkinson’s disease
Researchers are gaining new insights into neurological diseases by studying circular RNAs (circRNAs) in brain cells.
“Stereotyped, devalued and shunned.” Experts address treating the stigma of Parkinson’s disease
Even the best treatment approaches for Parkinson’s disease are inadequate if they do not address patients’ feelings of social rejection, isolation, loneliness and other psychosocial effects of stigma, according to a report from experts specializing in Parkinson’s and other movement disorders.
Can a Blood Test Detect Alzheimer’s Disease?
In July, the first direct-to-consumer blood test designed to assess a user’s risk for developing Alzheimer’s disease hit the market.
FAU and Insightec Partner to Use Focused Ultrasound to Treat Neurological Disorders
This agreement will enable FAU and Insightec to collaborate to advance scientific knowledge about the use of focused ultrasound to treat brain diseases, including Parkinson’s disease and Alzheimer’s disease. By harnessing acoustic energy, Insightec’s innovative technology uses focused ultrasound to treat diseases in different ways.
NeuroPoint Alliance’s Registry for the Advancement of DBS in Parkinson’s Disease Successfully Completes Pilot Phase
NeuroPoint Alliance’s (NPA) Registry for the Advancement of DBS in Parkinson’s Disease (RAD-PD) has successfully completed its Pilot Phase by achieving all data collection goals established at the beginning of registry creation.
Study: Misfolded alpha-synuclein protein key to early detection of Parkinson’s disease
The presence of a misfolded alpha-synuclein protein can be used to determine if people have Parkinson’s disease, according to a new study using technology developed by a researcher at UTHealth Houston. This biomarker could pave the way for the development of better diagnostic tools and new treatment options for the disease.
What Is Parkinson’s Disease? 10 Things to Know
Here are the history, symptoms, causes and treatment options for Parkinson’s.
For People with Parkinson’s Disease, Quality of Life Linked to Race, Ethnicity
Among those living with Parkinson’s disease, Black, Hispanic and Asian people were found to have a lower health-related quality of life than white people, according to a new study published in the April 5, 2023, online issue of Neurology® , the medical journal of the American Academy of Neurology.
New Focused Ultrasound Effective for treating Parkinson’s, Movement Disorders
In a study published in the New England Journal of Medicine co-authored by Vibhor Krishna, MD, associate professor of neurosurgery at the UNC School of Medicine, researchers show that a new focused ultrasound treatment improved dyskinesia and motor impairment in patients with Parkinson’s disease.
Study Finds Air Pollution Exposure Linked to Parkinson’s Risk, Identifies U.S. Hot Spot
Living in areas of the United States with higher levels of air pollution is associated with an increased risk of Parkinson’s disease, according to a preliminary study released today, February 23, 2023, that will be presented at the American Academy of Neurology’s 75th Annual Meeting being held in person in Boston and live online from April 22-27, 2023.
Nanopore-Based Sensing Device Explores Neurodegenerative Diseases
In Journal of Applied Physics, researchers present a special silicon nitride nanopore-based sensing device that is designed to provide volume information about tau and tubulin protein molecules and their aggregation states. To create the sensor, the team explored how the proteins change the current and voltage flowing through a nanopore system.
New blood test can detect ‘toxic’ protein years before Alzheimer’s symptoms emerge, study shows
Researchers can detect small “toxic” aggregates of a particular protein in the blood of individuals with Alzheimer’s disease and in individuals who showed no signs of cognitive impairment at the time the blood sample was taken, but who developed it at a later date.
Review: Are Climate Change and Air Pollution Making Neurologic Diseases Worse?
People with neurologic diseases like headache, dementia, multiple sclerosis (MS) and Parkinson’s disease may experience worsening symptoms due to climate change, according to a scoping review of research published in the November 16, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Cecilia Lindestam Arlehamn wins WHAM Edge Award funding to study sex-based differences in Alzheimer’s and Parkinson’s diseases
Cecilia Lindestam Arlehamn, Ph.D., aims to shed light on how sex-based immune system differences may affect the development and progression of these neurodegenerative diseases in men versus women.
Today: ANA2022 Media Roundtable to Spotlight Latest in Neuro Research
As the American Neurological Association’s 147th Annual Meeting wraps up today, October 25, the ANA is holding a Media Roundtable at 11 a.m. U.S. Central for reporters to access the latest developments in neurology and neuroscience.
An Environmental Wake-Up Call for Neurology
The Presidential Symposium at the American Neurological Association’s 2022 Annual Meeting (ANA2022) in Chicago will shine a spotlight on the role of environmental exposures — air pollution, pesticides, microplastics, and more — in diseases like dementias and developmental disorders.
American Neurological Association Publishes Research Abstracts for ANA2022, Oct. 22–25 in Chicago
Abstracts of breaking research in neurology and neuroscience, to be presented at the 2022 American Neurological Association Annual Meeting Oct. 22-25, are now available in Annals of Neurology and on the ANA2022 website.
Parkinson’s Disease: Uncovering Why Nicotine May Be Protective (for Some)
Parkinson’s disease is caused by a combination of genetic and environmental factors, one curious example being that people who smoke appear to be less likely to develop Parkinson’s. This may be due to interactions between nicotine and genetic variations in…
Multiple System Atrophy: Identifying Cells that Accelerate Disease Progression
There is currently no cure for the rare neurodegenerative disorder multiple system atrophy (MSA), and its rarity has made it difficult to understand how the disease progresses. Now a research team has created a successful mouse model of aggressive cerebellar-type…
Exercise Hormone Halts Parkinson’s Disease Symptoms in Mouse Study
Researchers from Johns Hopkins Medicine and the Dana Farber Cancer Institute in Boston have shown that a hormone secreted into the blood during endurance, or aerobic, exercise reduces levels of a protein linked to Parkinson’s disease and halts movement problems in mice.
Mayo Clinic Healthcare expert explains when swallowing issues are more than an accident
Many people have experienced the discomfort of food or a beverage accidentally going to the wrong place when swallowing. But swallowing issues sometimes become chronic and may be a sign of a health condition that should be treated.
World-First: A Biomarker That Can Diagnose Parkinson’s Disease
Researchers at Kobe University and Hiroshima University have successfully developed a biomarker that will enable Parkinson’s disease to be rapidly and inexpensively diagnosed from blood serum samples.
May Research Highlights
A Roundup of the Latest Medical Discoveries and Faculty News at Cedars-Sinai
‘Sting’ Protein’s Efforts to Clean Up Brain Cell Damage May Speed Parkinson’s Disease Progress
In studies with mouse and human tissue, as well as live mice, Johns Hopkins Medicine researchers report that a snag in the normal process of cleaning up broken DNA in brain cells may hasten the progression of Parkinson’s disease.
UTHealth Houston’s UTMOVE program receives distinguished Edmond J. Safra Fellowship in Movement Disorders
UTHealth Houston’s Movement Disorders and Neurodegenerative Diseases Fellowship Training Program (UTMOVE fellowship program) has been chosen by The Michael J. Fox Foundation for Parkinson’s Research (MJFF) as one of eight international academic centers to train a new movement disorder clinician-researcher — a neurologist with additional training and expertise in diagnosing and treating Parkinson’s and related diseases — as part of the Edmond J. Safra Fellowship in Movement Disorders Class of 2025.
April is Parkinson’s Disease Awareness Month
Parkinson’s Disease Awareness month is dedicated to raising awareness and support for patients suffering from this progressive brain disorder. Learn more about Parkinson’s disease, treatment options and support for those with Parkinson’s.