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Exploiting cancer cells to aid in their own destruction

March 24, 2021 sarah Jonas Cancer, Cancer Research, Immuno-therapy, Lymphatic System, Medical Science, Pritzker School of Molecular Engineering, tumors, University Of Chicago, Vaccines

Researchers at the Pritzker School of Molecular Engineering at the University of Chicago have developed a new therapeutic vaccine that uses a patient’s own tumor cells to train their immune system to find and kill cancer.

Research Results

Scientists kill cancer cells by “shutting the door” to the nucleus

September 25, 2020 sarah Jonas Cancer, Cancer Cells, Colorectal Cancer, Leukemia, Melanoma, tumors

Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that blocking the construction of nuclear pores complexes—large channels that control the flow of materials in and out of the cell nucleus—shrank aggressive tumors in mice while leaving healthy cells unharmed. The study, published in Cancer Discovery, a journal of the American Association for Cancer Research, reveals a new Achilles heel for cancer that may lead to better treatments for deadly tumors such as melanoma, leukemia and colorectal cancer.

Research Results

LLNL scientists pair 3D bioprinting and computer modeling to examine cancer spread in blood vessels

August 26, 2020 sarah Jonas 3D Bioprinting, Cancer, HPC, LLNL, Simulation, tumors

Lawrence Livermore National Laboratory scientists have paired 3D-printed, living human brain vasculature with advanced computational flow simulations to better understand tumor cell attachment to blood vessels, the first step in secondary tumor formation during cancer metastasis.

Research Results

New Treatment Developed by Children’s Hospital of Philadelphia Shows Success in High-Risk Solid Tumors

August 24, 2020 sarah Jonas Cancer, Drug Development, Oncology, Pediatric Cancer, Pediatrics, tumors

In a breakthrough study, researchers at Children’s Hospital of Philadelphia (CHOP) have shown that an enhanced treatment developed in their lab leads to long-term remissions in 80% to 100% of mice with drug-resistant or high-risk solid tumors. The research, which could soon lead to clinical trials, is described in Cancer Research, a journal of the American Association for Cancer Research.

Research Results

Chronic Stress Can Impact Response to Radiation Therapy for Cancer, Roswell Park Study Suggests

April 14, 2020 sarah Jonas Beta Blockers, Chronic Stress, Radiation Therapy, tumors

Radiation is one of the oldest and most common therapies for cancer, and typically is delivered locally, or to specific targeted sites in the body. While it has long been thought that locally-delivered radiation therapy typically does not help to shrink tumors outside the field of irradiation, new preclinical research from a team at Roswell Park Comprehensive Cancer Center suggests a strategy for significantly increasing both the local and distant, or “abscopal,” effects of radiation. Results of the study, which was led by Elizabeth Repasky, PhD, have been newly published in Nature Communications.

Research Results

Cancer Immunotherapy Target Helps Fight Solid Tumors

February 15, 2020 sarah Jonas Biophysical Society 64th Annual Meeting, Biophysical Society Annual Meeting, BPS, BPS20, Cancer, CAR-T, cars, chimeric antigen receptor, Immunotherapy, tumors, UCLA

Yvonne Chen engineers immune cells to target their most evasive enemy: cancer. New cancer immunotherapies generate immune cells that are effective killers of blood cancers, but they have a hard time with solid tumors.

Research Results

Most Rehabilitating Sea Turtles with Infectious Tumors Don’t Survive

January 22, 2020 sarah Jonas 0 Comments Herpes Virus, Infectious Diseases, Marine animals, Marine Life, Mortality, Surgery, Survival, Survivorship, Triage, tumors, Veterinary Medicine

Fibropapillomatosis (FP) is the most significant infectious disease affecting sea turtle populations worldwide. FB leads to tumors on the turtles’ eyes, flippers and internal organs and is widespread in warmer climates like Florida. A large-scale study evaluated tumor score, removal and regrowth in rehabilitating green sea turtles with FP in the southeastern U.S. from 2009 to 2017, and found that 75 percent did not survive following admission into a rehabilitation facility, irrespective of whether or not tumor regrowth occurred after surgery.

Research Tip Sheet

Science Snapshots From Berkeley Lab

December 23, 2019 sarah Jonas 0 Comments actinides, Advanced Light Source, Beamline, beamlines, bioactinide, Biology, Biosciences, Cancer Drug, chelation of actinides, Chelators, chemical sciences, chemical synthesis, Colorectal Cancer, Department of Energy (DOE), Heavy Metals, Lanthanides, Lawrence Berekely National Laboratory, lung adenocarcinoma, Molecular Foundry, MRI contrast agents, Office of Science, Physics, Plutonium, tumors, UC Berkeley, X-Ray

This edition of Science Snapshots highlights the discovery of an investigational cancer drug that targets tumors caused by mutations in the KRAS gene, the development of a new library of artificial proteins that could accelerate the design of new materials, and new insight into the natural toughening mechanism behind adult tooth enamel.

Research Results

Better Biosensor Technology Created for Stem Cells

November 11, 2019 sarah Jonas 0 Comments Alzheimer’s disease, biomarkers, Brain, Cells, Chemical Biology, Chemistry, Diabetes, genes, Genetics, GOLD, Graphene, Heart Disease, Macular Degeneration, Nanomaterials, Nanostructures, National Institutes of Health, Neurological Disorders, Neurons, New Jersey, NJ, Osteoarthritis, Parkinson’s disease, proteins, Rheumatoid Arthritis, Rutgers, Rutgers University-New Brunswick, South Korea, Stem Cell Therapy, Stem Cells, Stroke, Tech, Technology, Treatment, tumors

A Rutgers-led team has created better biosensor technology that may help lead to safe stem cell therapies for treating Alzheimer’s and Parkinson’s diseases and other neurological disorders. The technology, which features a unique graphene and gold-based platform and high-tech imaging, monitors the fate of stem cells by detecting genetic material (RNA) involved in turning such cells into brain cells (neurons), according to a study in the journal Nano Letters.

Research Results

Marker reveals if benign-appearing meningiomas are perilous

November 4, 2019 sarah Jonas 0 Comments Brain Cancer, Neurosurgery, Oncology, tumors

A modified protein in benign-appearing meningiomas can reveal which are truly benign and which are more dangerous and require more aggressive treatment, researchers have discovered.