A new Wistar Institute study shows how key features on the surface of HIV-infected cells help the disease evade detection by the immune system.
Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different “program” that makes them less effective than immune cells in patients whose cancers respond to these immune treatments, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy.
A recent study led by an Iowa State University entomologist explores the different kinds of cells that make up mosquito immune systems. The research could shed light on how mosquitoes transmit malaria.
Research in mice reveals how a subset of highly specialized immune cells modulate brain wiring by precision-targeting inhibitory synapses.
The work deepens understanding of the versatile repertoire of microglia, the brain’s immune cells and resident garbage collectors.
The results set the stage for the development of therapies for neurodevelopmental and psychiatric conditions marked by defects in synaptic function.
A dysfunctional immune system significantly contributes to the development of cancer. Several therapeutic strategies to activate the immune system to target cancer cells have been approved to treat different types of cancer, including melanoma.
Creating “super soldiers” of specific white blood cells to boost an anti-tumour response has been shown in a series of elegant experiments by Princess Margaret researchers.
The healthy human oral microbiome consists of not just clean teeth and firm gums, but also bacteria living in an environment where they constantly communicate with the immune system. A growing body of evidence has shown that this system is highly influential on, and influenced by, our overall health.
Johns Hopkins Kimmel Cancer Center investigators report they have uncovered a new mechanism by which invasive breast cancer cells evade the immune system to metastasize, or spread, to other areas of the body. They propose that therapies targeting this process could be developed to halt or prevent metastasis and reduce breast cancer deaths.
The recognition of bacterial infections or foreign substances is mediated and controlled by the human immune system. This innate and adaptive immune system comprises the most important metabolic and cellulare processes to fight against infections and other diseases.
VICC is the first cancer center to enroll a patient in a clinical trial for this new technology developed by SQZ Biotechnologies of Watertown, Massachusetts. The investigational product is generated from the company’s technology that uses high-speed cell deformation to squeeze cells, creating a temporary disruption of their membranes and offering a window for the insertion of tumor antigens.
Researchers have developed a way to prop up a struggling immune system to enable its fight against sepsis, a deadly condition resulting from the body’s extreme reaction to infection.
Immunotherapy has become a standard treatment approach for several types of cancer, including melanoma. However, tumors can escape immune cell detection even with the use of immunotherapies. In a new study published in Cancer Immunology Research, Moffitt Cancer Center researchers, in collaboration with the University of Miami’s Miller School of Medicine, describe a cellular mechanism that controls tumor cell recognition by immune cells.
A new study, led by researchers at the University of Chicago, provides an answer to why cancer cells consume and use nutrients differently than their healthy counterparts and how that difference contributes to their survival and growth.
Blocking the mineralocorticoid receptor (MR)—a protein that helps maintain normal levels of salt and water in the body—in immune cells may help reduce the risk of heart attack and stroke by improving blood vessel health. The study will be presented today at the American Physiological Society (APS) Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference in Estes Park, Colo.