Researchers Find Link between Immune Cell Traits and Parkinson’s Disease

Article title: Genetic causal relationship between multiple immune cell phenotypes and Parkinson’s disease: a two-sample bidirectional Mendelian randomization study Authors: Hong Chen, Xie Wang, Ze Chang, Juan Zhang, Daojun Xie From the authors: “Our study identified a close link between immune cells and…

Researchers develop a new way to safely boost immune cells to fight cancer

Researchers in the College of Engineering explore a cancer immunotherapy treatment that involves activating the immune cells in the body and reprogramming them to attack and destroy cancer cells. This therapeutic method frequently uses cytokines, small protein molecules that act as intercellular biochemical messengers and are released by the body’s immune cells to coordinate their response.

Army of specialized T cells may trigger asthma attacks in older men

LA JOLLA, CA—Scientists from La Jolla Institute for Immunology (LJI) and The University of Southampton, UK, have uncovered a group of immune cells that may drive severe asthma. These cells, called cytotoxic CD4+ tissue-resident memory T cells, gather in the lungs and appear to possess the molecular weaponry to cause the most harm in men who developed asthma later in life.

Fresh understanding of ageing in the brain offers hope for treating neurological diseases

Scientists from the Trinity Biomedical Sciences Institute (TBSI) have shed new light on ageing processes in the brain. By linking the increased presence of specialised immune cells to conditions such as Alzheimer’s disease and traumatic brain injury for the first time, they have unearthed a possible new target for therapies aimed at treating age-related neurological diseases.

Commonly used antiretroviral drugs used to treat HIV and hepatitis B reduce immune cells’ energy production

New UCLA-led research suggests that antiretroviral drugs called TAF and TDF directly reduce energy production by mitochondria, structures inside cells that generate the power that cells use to function. Both drugs led to reduced cellular oxygen consumption rates, a measure of the ability of the mitochondria to produce energy, compared with controls.

A Consistent Lack of Sleep Negatively Impacts Immune Stem Cells, Increasing Risk of Inflammatory Disorders and Heart Disease

Mount Sinai study also shows catching up on sleep doesn’t reverse possible negative effects on cellular level

Right Program Could Turn Immune Cells into Cancer Killers

Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different “program” that makes them less effective than immune cells in patients whose cancers respond to these immune treatments, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy.

The Brain’s Wiring Technicians

Research in mice reveals how a subset of highly specialized immune cells modulate brain wiring by precision-targeting inhibitory synapses.
The work deepens understanding of the versatile repertoire of microglia, the brain’s immune cells and resident garbage collectors.
The results set the stage for the development of therapies for neurodevelopmental and psychiatric conditions marked by defects in synaptic function.

Breast Cancer Cells Can Reprogram Immune Cells to Assist in Metastasis

Johns Hopkins Kimmel Cancer Center investigators report they have uncovered a new mechanism by which invasive breast cancer cells evade the immune system to metastasize, or spread, to other areas of the body. They propose that therapies targeting this process could be developed to halt or prevent metastasis and reduce breast cancer deaths.

Vanderbilt-Ingram Cancer Center Patient First for New Cell Engineering Platform

VICC is the first cancer center to enroll a patient in a clinical trial for this new technology developed by SQZ Biotechnologies of Watertown, Massachusetts. The investigational product is generated from the company’s technology that uses high-speed cell deformation to squeeze cells, creating a temporary disruption of their membranes and offering a window for the insertion of tumor antigens.

Moffitt Researchers Identify a Mechanism Controlling Tumor Cell Recognition by Immune Cells

Immunotherapy has become a standard treatment approach for several types of cancer, including melanoma. However, tumors can escape immune cell detection even with the use of immunotherapies. In a new study published in Cancer Immunology Research, Moffitt Cancer Center researchers, in collaboration with the University of Miami’s Miller School of Medicine, describe a cellular mechanism that controls tumor cell recognition by immune cells.

University of Chicago scientists unveil the secret of cancer-associated Warburg effect

A new study, led by researchers at the University of Chicago, provides an answer to why cancer cells consume and use nutrients differently than their healthy counterparts and how that difference contributes to their survival and growth.

Blocking a Hormone’s Action in Immune Cells May Reduce Heart Disease Risk

Blocking the mineralocorticoid receptor (MR)—a protein that helps maintain normal levels of salt and water in the body—in immune cells may help reduce the risk of heart attack and stroke by improving blood vessel health. The study will be presented today at the American Physiological Society (APS) Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference in Estes Park, Colo.