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UrduStress is inevitable. But too much of it can be terrible for our health. Chronic stress can increase our risk for heart disease and strokes. It may also help cancer spread. How this works has remained a mystery—a challenge for cancer care.
Tag: Chronic Stress
Study indicates possible link between chronic stress and Alzheimer’s disease
Researchers from Karolinska Institutet have published a study in Alzheimer’s Research & Therapy that addresses possible associations between chronic stress, mild cognitive impairment and Alzheimer’s disease.
Chronic stress-related neurons identified
Researchers at Karolinska Institutet in Sweden have identified a group of nerve cells in the mouse brain that are involved in creating negative emotional states and chronic stress.
Neurosteroid Deficits Leads to Depressed Behavior
A study in mice, led by Tufts University School of Medicine scientists, found chronic stress reduced an animal’s abilities to produce and respond to neurosteroids, specifically allopregnanolone.
It’s easier to forgive when you are under chronic stress
Russian researchers have studied the correlation between personality authenticity (the ability to be oneself) and the ability to forgive under different levels of stress. They found that people experiencing chronic stress are more inclined to forgive, while people affected by everyday stress are less inclined to do so.
Roswell Park Researchers Identify Key Link Between Stress and Cancer
Stress can have a significant negative effect on health, but our understanding of how stress impacts the development and progression of cancer is just beginning. A team from Roswell Park Comprehensive Cancer Center has identified an important mechanism by which chronic stress weakens immunity and promotes tumor growth. Their findings, just published in Cell Reports, point to the beta-adrenergic receptor (β-AR) as a driver of immune suppression and cancer growth in response to stress, opening the possibility of targeting this receptor in cancer therapy and prevention.
Alcohol use among sexual minority adolescents is linked to discrimination and stigmatization
Sexual minority adolescents – lesbian, gay, or bisexual youth – are at an increased risk for substance use, including alcohol. A new study finds that discriminatory and stigmatizing experiences may be to blame. These results and others will be shared at the 44th annual scientific meeting of the Research Society on Alcoholism (RSA), which due to the COVID-19 pandemic will be held virtually this year from the 19th – 23rd of June 2021.
Immune from Chronic Stress? Limit Inflammatory Signaling to Specific Brain Circuits
Chronic stress is associated with the pathogenesis of psychological disorders such as depression. A study is the first to identify the role of a neuronal receptor that straddles the intersection between social stress, inflammation, and anxiety in rodent models of stress. Findings suggest the possibility of developing better medications to treat the consequences of chronic stress by limiting inflammatory signaling not just generally, which may not be beneficial in the long run, but to specific brain circuits.
Untangling the Effects of Past Adversity and Alcohol Use Disorder on Acute Stress Responses
The hypothalamic–pituitary–adrenal (HPA) axis is the body’s key stress response system. By driving production of the stress hormone cortisol, and then ensuring a return to baseline levels, the HPA axis regulates our reaction to stressful events. Chronic alcohol use, however, can lead to persistently elevated cortisol, reducing the body’s capacity to respond appropriately to stress. Among people in treatment for alcohol use disorder (AUD), the blunted stress response predicts risk of relapse and a return to drinking. Longer-term life stress, including childhood adversity, post-traumatic stress disorder (PTSD), and chronic stress, can also dampen HPA axis function, complicating interpretation of the alterations evident in people with AUD. However, it is not known how stress and trauma intereact with AUD to affect HPA-axis reactivity. A new report in Alcoholism: Clinical and Experimental Research by researchers from the universities of Texas, Florida, and Colorado addresses this issue, u
Chronic Stress Can Impact Response to Radiation Therapy for Cancer, Roswell Park Study Suggests
Radiation is one of the oldest and most common therapies for cancer, and typically is delivered locally, or to specific targeted sites in the body. While it has long been thought that locally-delivered radiation therapy typically does not help to shrink tumors outside the field of irradiation, new preclinical research from a team at Roswell Park Comprehensive Cancer Center suggests a strategy for significantly increasing both the local and distant, or “abscopal,” effects of radiation. Results of the study, which was led by Elizabeth Repasky, PhD, have been newly published in Nature Communications.