UC Irvine-led research team builds first tandem repeat expansions genetic reference maps

A research team led by the University of California, Irvine has built the first genetic reference maps for short lengths of DNA repeated multiple times which are known to cause more than 50 lethal human diseases, including amyotrophic lateral sclerosis, Huntington’s disease and multiple cancers.

Penn scientists create novel technique to form human artificial chromosomes

Human artificial chromosomes (HACs) capable of working within human cells could power advanced gene therapies, including those addressing some cancers, along with many laboratory applications, though serious technical obstacles have hindered their development. Now a team led by researchers at the Perelman School of Medicine at the University of Pennsylvania has made a significant breakthrough in this field that effectively bypasses a common stumbling block.

Scientists ID burned bodies using technique used for extracting DNA from wooly mammoths, Neanderthals

A technique originally devised to extract DNA from woolly mammoths and other ancient archaeological specimens can be used to potentially identify badly burned human remains, according to research from Binghamton University, State University of New York.

Companion Penn Medicine Studies on AAV-based Gene Therapies in Non-Human Primates Suggest Integration into Human DNA is Unlikely to Drive Cancer Mutations While Offering the Potential for Durable Expression of the Transgene

Gene therapy adeno-associated viruses (AAVs)—viruses that can be engineered to deliver DNA to target cells—are unlikely to cause cancer-triggering insertions in humans or monkeys and may contribute to long-term efficacy, according to new research from the University of Pennsylvania’s Gene Therapy Program (GTP).

Markey Cancer Center study provides valuable insights into drivers of cancer risk

As people age, the DNA in their cells begins to accumulate genetic mutations. Mosaic chromosomal alterations (mCAs), a category of mutations acquired in blood cells, are linked with a 10-fold increased risk of developing blood cancer.  mCAs hold promise as a tool to identify people at high risk of developing certain cancers and diseases, but they have not yet been studied among a large, diverse cohort of people – a critical step required before such testing can be developed. University of Kentucky Markey Cancer Center researcher Yasminka A. Jakubek, Ph.D., has led the first large-scale effort to understand the co-occurrence of mCAs among individuals of diverse ancestries. The study was published in Nature Genetics Oct. 30.

Green Genetic Engineering: Making Mendel’s Dream Come True with Molecular Scissors

Molecular biologist Professor Holger Puchta from Karlsruhe Institute of Technology (KIT) is granted funding within a Reinhart Koselleck Project by the German Research Foundation (DFG) for work on specific restructuring of plant genomes. Puchta, a pioneer of green genetic engineering,…

DNA Decodes the Dining Preferences of the Shell-Shucking Whitespotted Eagle Ray

With mighty jaws and plate-like teeth, the globally endangered whitespotted eagle ray can pretty much crunch on anything. Yet, little information is available on critical components of their life history in the U.S., such as their diet.

The Alliance for Genomic Discovery announces founding biopharma members: AbbVie, Amgen, AstraZeneca, Bayer and Merck

Illumina Inc., a global leader in DNA sequencing and array-based technologies, in collaboration with Nashville Biosciences LLC, a leading clinical and genomic data company and wholly owned subsidiary of Vanderbilt University Medical Center, today announced the five founding new members of the Alliance for Genomic Discovery (AGD).

RNA Institute Researchers Advance DNA Nanostructure Stability

Researchers at the University at Albany’s RNA Institute have demonstrated a new approach to DNA nanostructure assembly that does not require magnesium. The method improves the biostability of the structures, making them more useful and reliable in a range of applications.

How Breast Cancer Arises

At a glance:

Researchers trace the origin of certain breast cancers to genomic reshuffling — rearrangement of chromosomes — that activates cancer genes and ignites disease.
The finding offers a long-missing explanation for many cases of the disease that remain unexplained by the classical model of breast cancer development.
The study shows the sex hormone estrogen — thus far thought to be only a fuel for breast cancer growth — can directly cause tumor-driving genomic rearrangements.

Van Andel Institute, Washington University School of Medicine in St. Louis to lead genome center under $140M NIH initiative

Van Andel Institute’s Hui Shen, Ph.D., and Washington University School of Medicine in St. Louis’s Ting Wang, Ph.D., will co-lead a collaborative project supported by the Somatic Mosaicism across Human Tissues (SMaHT) Network, a new $140 million National Institutes of Health-led effort to better understand the genetic differences between individual cells and tissues in the body.

UNLV Study Sheds Light on Ancient Microbial Dark Matter

Omnitrophota are nano-sized bacteria first discovered 25 years ago. Though common in many environments around the world, until now they’ve been poorly understood. An international research team produced the first large-scale analysis of Omnitrophota genomes, uncovering new details about their biology and behavior. The team’s findings are reported in the March 16 issue of the journal Nature Microbiology.

Ochsner Health Advances Precision Medicine, Becomes National Leader in Universal Genomic Testing for Chemotherapy

Ochsner Health is leading the way for precision medicine nationwide by becoming one of the first hospital systems to standardize genomic testing, significantly advancing ways in which care teams can treat cancer patients. This change helps providers determine individualized treatment by understanding how patients will react to certain drugs, thereby lowering risk of adverse side effects, improving patient experience, and bettering patient outcomes.

Chula Researches “Tooth Loss” in Thai People- A Hereditary Condition Caused by Genetic Abnormalities

Chulalongkorn dental research reveals that Thais suffer more tooth loss than their foreign counterparts with 9 out of 100 Thais suffering the condition. One of the most important factors is hereditary gene abnormalities.

New Low-cost Device Rapidly, Accurately Detects Hepatitis C Infection

The entire virus detection process is executed inside a uniquely designed, portable, inexpensive, disposable, and self-driven microfluidic chip. The fully automated sample-in–answer-out molecular diagnostic set-up rapidly detects Hepatitis C virus in about 45 minutes and uses relatively inexpensive and reusable equipment costing about $50 for sample processing and disease detection. The disposable microfluidic chip also offers shorter times for a reliable diagnosis and costs about $2.