How Breast Cancer Arises

At a glance:

Researchers trace the origin of certain breast cancers to genomic reshuffling — rearrangement of chromosomes — that activates cancer genes and ignites disease.
The finding offers a long-missing explanation for many cases of the disease that remain unexplained by the classical model of breast cancer development.
The study shows the sex hormone estrogen — thus far thought to be only a fuel for breast cancer growth — can directly cause tumor-driving genomic rearrangements.