Article title: 17β-estradiol promotes sex-specific dysfunction in isolated human arterioles Authors: Gopika SenthilKumar, Boran Katunaric, Henry Bordas-Murphy, Micaela Young, Erin L. Doren, Mary E. Schulz, Michael E. Widlansky, Julie K. Freed From the authors: “To our knowledge, this is the…
Low Estrogen Levels Paired with Higher CGRP Levels May Jump Start Migraine
As estrogen levels fluctuate, a new study has found for female participants with migraine, their levels of the protein calcitonin gene-related peptide (CGRP) that plays a key role in starting the migraine process also fluctuate. The study is published in the February 22, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Does Lifetime Exposure to Estrogen Affect Risk of Stroke?
People with a higher cumulative estrogen exposure throughout their life may have a lower risk of stroke, according to a new study published in the February 1, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. The lower risk was found for both ischemic stroke and intracerebral hemorrhage.
Gender Affirmation Treatment Delivery Route May Affect Heart Health
Transgender and gender diverse (TGD) people assigned male at birth are at increased heart health risk. The delivery route of estrogen medication is known to affect heart health risk in cisgender women. However, research is lacking on how estrogen route affects heart health in the TGD population.
Hormone therapy could lower risk of immunotherapy-associated myocarditis in women
A new preclinical study from researchers at The University of Texas MD Anderson Cancer Center and the University of California San Francisco (UCSF) has discovered the underlying cause of gender differences in immunotherapy-associated myocarditis after immune checkpoint inhibitor (ICI) treatment. Their findings point to possible treatment strategies for this side effect, which disproportionately affects female patients.
Changing Hormone Levels Post-menopause Leads to Vascular Impairment in Female Mice
Article title: Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice Authors: Jade A. Blackwell, Josiane F. Silva, Emma M. Louis, Andrea Savu, Tally M. Largent-Milnes, Heddwen L. Brooks, Paulo W. Pires From the authors: “Together, our data…
Does Estrogen Protect Against the Risk of Brain Shrinkage?
A new study found that people with higher cumulative estrogen exposure over their lifetime had greater brain volumes and fewer indicators of brain disease on their brain scans in midlife . The research is published in the November 3, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Menopausal Changes May Increase Taste for Fat, Drive Weight Gain
A new study in mice suggests that declining estrogen levels lower the taste buds’ sensitivity to fats, which may drive a heightened appetite for fatty foods—and weight gain—after menopause.
New discovery in breast cancer treatment
Researchers at the University of Adelaide have found new evidence about the positive role of androgens in breast cancer treatment with immediate implications for women with estrogen receptor-driven metastatic disease.
Testosterone May Contribute to More Severe COVID-19 Disease
New research suggests that levels of the sex hormones estrogen and testosterone could contribute to infection risk and severity of COVID-19.
Sex Hormones Contribute to Sex Differences in COVD-19
Article title: Sex steroids skew ACE2 expression in human airway: a contributing factor to sex differences in COVID-19? Authors: Rama Satyanarayana Raju Kalidhindi, Niyati A. Borkar, Nilesh Sudhakar Ambhore, Christina M. Pabelick, Y. S. Prakash, Venkatachalem Sathish From the authors:…
Estrogenic and anti-estrogenic effects of PFASs could depend on the presence of estrogen
Researchers reporting in ACS’ Environmental Science & Technology have used a combination of laboratory experiments and computer modeling to reveal that PFASs can interact with the estrogen receptor in different ways to influence estrogen-controlled gene expression.
Estrogen May Lessen Severity of COVID-19 Symptoms in Women, Study Says
Why are men at greater risk than women for more severe symptoms and worse outcomes from COVID-19 regardless of age?
Researchers discover sex-specific differences in neural mechanisms for glucose regulation
Researchers from Tufts have discovered neural mechanisms in mice specific to females that switch estrogen from playing a protective role in glucose metabolism to a disruptive role. The discovery could provide clues to the increased risk of insulin resistance and diabetes among post-menopausal women.
Why Do More Women Have Alzheimer’s than Men? It’s Not Just from Living Longer
Middle-aged women are more likely than men to have changes in the brain related to Alzheimer’s disease, as detected by imaging, even when there are no differences in thinking and memory. This may be associated with hormonal changes due to menopause, specifically the loss of estrogen, according to a study published in the June 24, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Does estrogen influence alcohol use disorder?
Researchers show that high estrogen levels may make alcohol more rewarding to female mice and reducing the number of estrogen receptors led to decreased drinking behavior, but only in female mice.