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UrduA new study by UT Southwestern scientists indicates that an enzyme called protein phosphatase 2 (PP2A) appears to be a major driver of preeclampsia, a dangerous pregnancy complication characterized by the development of high blood pressure and excess protein in the urine. The finding, published in Circulation Research, could lead to new treatments for preeclampsia other than premature delivery, which is often the only option.
Tag: Preeclampsia
Hopkins Med News Update
News stories in this issue
Rat Model of Preeclampsia Gives new Insight into Immunological Changes during Pregnancy
Article title: Immunological comparison of pregnant Dahl salt-sensitive and Sprague-Dawley rats commonly used to model characteristics of preeclampsia Authors: Erin B. Taylor, Eric M. George, Michael J. Ryan, Michael R. Garrett, Jennifer M. Sasser From the authors: “The current study…
Association between Hypertension and Gut Microbiome Imbalance during Pregnancy May Lead to New Preeclampsia Treatments
Article title: Gestational gut microbial remodeling is impaired in a rat model of preeclampsia superimposed on chronic hypertension Authors: Jeanne A. Ishimwe, Adesanya Akinleye, Ashley C. Johnson, Michael R. Garrett, Jennifer M. Sasser From the authors: “These results reveal an…
Exposure to Vitamin D in the Womb Might Minimize Risk of High Blood Pressure for Children Born to Mothers with Preeclampsia
Children appear to be at greater risk of having high blood pressure when their mothers had the high blood pressure condition called preeclampsia during pregnancy—but this adverse association may be reduced or even eliminated for children who were exposed to higher levels of vitamin D in the womb.
Placental Release of Iron Affects Post-birth Nitric Oxide Balance
Article title: Evidence for placental-derived iron-nitrosyls in the circulation of the fetal lamb and against a role for nitrite in mediating the cardiovascular transition at birth Authors: Arlin B. Blood, Taiming Liu, George Mukosera, Shawn F. Hanson, Michael H. Terry, Hobe…
High blood pressure during pregnancy may mean worse hot flashes during menopause
Women with a history of high blood pressure disorders during pregnancy are more likely to experience bothersome menopausal symptoms such as hot flashes and night sweats, according to a study published Wednesday, Aug. 19, in Menopause: The Journal of the North American Menopause Society.
Maternal obesity increases risk of potentially deadly hypertensive disorders early in pregnancy
Pregnant obese women were more at risk of experiencing early and late-onset hypertensive disorders, and that risk progressively increased in women with higher body mass indexes (BMI), according to a study led by researchers at UTHealth.
Higher Manganese Levels in Early Pregnancy Linked to Lower Preeclampsia Risk
An analysis of data from more than 1,300 women followed prospectively through pregnancy found that women with lower levels of the essential mineral manganese in early pregnancy were more likely to develop the serious high blood pressure syndrome called preeclampsia in late pregnancy.
Pregnancy Complications in Assisted Reproduction Linked to a Specific Process
An experimental study from researchers in the Perelman School of Medicine at the University of Pennsylvania links a specific procedure – embryo culture – that is part of the assisted reproduction process (ART) to placental abnormalities, risk for preeclampsia, and abnormal fetal growth. The team, led by Marisa Bartolemei, PhD, a professor of Cell and Developmental Biology, published their findings today in Development.
RNA Molecules in Maternal Blood May Predict Pregnancies at Risk for Preeclampsia
UC San Diego researchers have identified small molecules in the blood of asymptomatic pregnant women that may predict risk for preeclampsia, responsible for a significant proportion of maternal and neonatal deaths, low birth weight and is a primary cause of premature birth.
Pregnant Women with Very High Blood Pressure Face Greater Heart Disease Risk
Women with preeclampsia are four times more likely to suffer a heart attack or cardiovascular death, Rutgers study finds
Rutgers Expert Available to Discuss Global Fisheries Management Study
New Brunswick, N.J. (Jan. 13, 2020) – Rutgers University–New Brunswick Professor Olaf P. Jensen is available for interviews on new marine fisheries management research to be published in the journal Proceedings of the National Academy of Sciences. The study is the most comprehensive…
Early Diagnosis of Pregnancy-Associated Heart Disease Linked to Significantly Better Outcomes
Women who are diagnosed with peripartum cardiomyopathy (PPCM) during late pregnancy or within a month following delivery are more likely to experience restored cardiac function and improved outcomes compared to those who are diagnosed later in the postpartum period.