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UrduArticle title: Dietary anions control potassium excretion: it is more than a poorly absorbable anion effect Authors: Lama Al-Qusairi, Mohammed Z. Ferdaus, Truyen D. Pham, Dimin Li, P. Richard Grimm, Ava M. Zapf, Delaney C. Abood, Ebrahim Tahaei, Eric Delpire,…
Tag: Kidney Health
Researchers Explore Proteins’ Roles in Cilia Associated with Polycystic Kidney Disease
Article title: CFTR and PC2, partners in the primary cilia in autosomal dominant polycystic kidney disease Authors: Murali K. Yanda, Cristian Ciobanu, William B. Guggino, Liudmila Cebotaru From the authors: “Here we show that [cystic fibrosis transmembrane conductance regulator (CFTR)]…
Enzyme in T Cells Worsens Salt-sensitive Hypertension and Related Kidney Damage
Article title: Functional NADPH oxidase 2 (NOX2) in T cells amplifies salt-sensitive hypertension and associated renal damage Authors: Samuel D. Walton, John Henry Dasinger, Emily C. Burns, Mary Cherian-Shaw, Justine M. Abais-Battad, David L. Mattson From the authors: “The results…
AACC and National Kidney Foundation Release Guidance to Combat Racial and Gender Inequalities in Chronic Kidney Disease Care
Today, AACC—in collaboration with the National Kidney Foundation (NKF)—released guidance to reduce racial and gender disparities in the care of patients with chronic kidney disease (CKD). The document gives members of the healthcare team actionable, evidence-based tools to improve equity in kidney health, including recommendations for using an updated algorithm that does not disproportionately affect any one group of individuals.
Researchers Propose New Mouse Model to Study Gene Targeting in Kidney’s Thick Ascending Limb
Article title: A novel mouse model for an inducible gene modification in the renal thick ascending limb Authors: Laurent Bourqui, Denise V. Winter, Alex Odermatt, Dominique Loffing-Cueni, Johannes Loffing From the authors: “This study describes a novel transgenic mouse model…
American Society of Nephrology Statement on Health Resources and Services Administration Initiative to Modernize Organ Procurement and Transplantation Network
The American Society of Nephrology (ASN) welcomes the significant changes to the Organ Procurement and Transplantation Network (OPTN)—a sweeping “OPTN Modernization Initiative”—announced today by Health Resources and Services Administration (HRSA) Administrator Carole Johnson.
Researchers ID Kidney Pathway Involved with Autoimmune-related Hypertension in Female Mice
Article title: Renal TLR-7/ TNF-α pathway as a potential female-specific mechanism in the pathogenesis of autoimmune-induced hypertension Authors: Sarika Chaudhari, Bradley M. D’Souza, Jessica Y. Morales, Cassandra M. Young-Stubbs, Caroline G. Shimoura, Rong Ma, Keisa W. Mathis From the authors:…
Kidneycure Grant Applications Now Open to Support Investigators Committed to Advancing Kidney Health
KidneyCure, the grants program supported by the American Society of Nephrology (ASN) Foundation, today announced that applications for its 2023 grants programs are now open. KidneyCure grants support clinical and basic research and kidney health investigators at key professional development milestones. The submission deadline is Wednesday, December 7, 2022, at 2:00 p.m. EST. Grant applications and guidelines can be found at https://www.kidneycure.org/
Blocking Estrogen in Breast Cancer May Affect Blood Pressure, Kidney Health
Article title: Aromatase inhibition increases blood pressure and markers of renal injury in female rats Authors: Rawan N. Almutlaq, Annie E. Newell-Fugate, Louise C. Evans, Huma Fatima, Eman Y. Gohar From the authors: “The present findings demonstrate that systemic anastrozole…
Researchers Present New Mathematical Model for Studying Kidney Cells
Rockville, Md. (September 13, 2022)—Research published ahead of print in the journal Function presents a new mathematical model using opossum kidney cells to study the endocytic capacity of proximal tubule cells in the kidneys. The specialized cells in the proximal…
Flozin Drugs Lower Salt-Induced Hypertension, Maintain Circadian Rhythm in Rats
Article title: SGLT2 inhibition effect on salt-induced hypertension, RAAS and Na+ transport in Dahl SS rats Authors: Olha Kravtsova, Ruslan Bohovyk, Vladislav Levchenko, Oleg Palygin, Christine A. Klemens, Timo Rieg, Alexander Staruschenko From the authors: “The main findings of the…
KIDNEYCURE ANNOUNCES 2022 GRANT RECIPIENTS
KidneyCure (the ASN Foundation) is honored to continue its support of investigators committed to advancing kidney health. Building on decades of success, KidneyCure makes it possible to improve knowledge and treatment by identifying and funding high-impact projects.
Intermittent Fasting Protects Kidneys of Obese Mice
New research in mice finds that time-restricted feeding improves markers of kidney and vascular health. The research will be presented this week at the American Physiological Society and American Society for Nephrology Control of Renal Function in Health and Disease conference.
Past Kidney Disease May Increase Preeclampsia Risk, Impair Blood Vessel Health during Pregnancy
A history of kidney problems may put people at a higher risk for impaired blood vessel function, which could lead to high blood pressure, preterm labor and other adverse outcomes, according to the results of a study in rats. The researchers will present their work this week at the American Physiological Society (APS) and American Society for Nephrology Control of Renal Function in Health and Disease conference in Charlottesville, Virginia.
Vitamin D Supplements May Offset Bone Loss Caused by Diabetes Drug
Vitamin D supplementation may help offset damaging bone loss that occurs in some people who take canagliflozin, a commonly prescribed diabetes drug. Researchers will present their work this week at the American Physiological Society (APS) and American Society for Nephrology Control of Renal Function in Health and Disease conference in Charlottesville, Virginia.
Kidney Stone Formation Linked to Polycystic Kidney Disease in Mice
Article title: Kidney stone formation in a novel murine model of polycystic kidney disease Authors: Heather A.L. Riddle, Shiqin Zhang, Feng Qian, James C. Williams Jr., Jason R. Stubbs, Peter Stanley N. Rowe, Stephen C. Parnell From the authors: “Our…
Mom’s Pregnancy Diet and Low Birth Weight Can Impact Kidney Size at Birth, But Not in Adulthood
Article title: Podocyte endowment and the impact of adult body size on kidney health Authors: Luise A. Cullen-McEwen, James van der Wolde, Kotaro Haruhara, Leon Tribolet, John P. Dowling, Michael G. Bertram, Robert de Matteo, Fabian Haas, Jan Czogalla, Yusuke…
AMERICAN SOCIETY OF NEPHROLOGY AND 19 KIDNEY COMMUNITY ORGANIZATIONS CALL ON CONGRESS TO PROTECT LIVING DONORS, FUND RESEARCH AND INNOVATION, AND REMOVE BARRIERS TO TELEHEALTH
Today, advocates of the American Society of Nephrology (ASN) and 19 other kidney health professional and patient organizations are meeting with their congressional delegations, calling on them to enact policies to improve kidney health
Researchers ID Protein Complex That Plays Important Role in Kidneys’ Water Balance Pathways
Article title: Actin-related protein 2/3 complex plays a critical role in the aquaporin-2 exocytotic pathway Authors: Chen-Chung Steven Liu, Pui Wen Cheung, Anupama Dinesh, Noah Baylor, Theodor C. Paunescu, Anil V. Nair, Richard Bouley, Dennis Brown From the authors: “In…
Intrauterine Growth Restriction in Rats Causes Long-term Increases in Offspring’s Blood Pressure, Impairs Renal Artery Vascular Tone
Article title: Vascular tone regulation in renal interlobar arteries of male rats is dysfunctional after intrauterine growth restriction Authors: Jenny Voggel, Lubomir Lubomirov, Felix Lechner, Gregor Fink, Eva Nüsken, Maria Wohlfarth, Gabriele Pfitzer, Kija Shah-Hosseini, Martin Hellmich, Miguel A. Alejandre…
Assessing Patients’ Kidney Health May Help Predict Their Risk of Cardiovascular Disease
• Adding measures of kidney function to traditional measures of cardiovascular health could help clinicians predict an individual’s risk of developing cardiovascular disease.
Nicotine Damages Kidney Filters in Smokers with Diabetes
Article title: Nicotine, smoking, podocytes and diabetic nephropathy Authors: Edgar A. Jaimes, Ming-Sheng Zhou, Mohammed Siddiqui, Gabriel Rezonzew, Runxia Tian, Surya V. Seshan, Alecia N Muwonge, Nicholas J. Wong, Evren U. Azeloglu, Alessia Fornoni, Sandra Merscher, Leopoldo Raij From the authors:…
High Potassium May Interfere with Electrolyte Balance in Kidneys
Article title: WNKs are potassium-sensitive kinases Authors: John M. Pleinis, Logan Norrell, Radha Akella, John M. Humphreys, Haixia He, Qifei Sun, Feng Zhang, Jason Sosa-Pagan, Daryl E. Morrison, Jeffrey N. Schellinger, Laurie K. Jackson, Elizabeth J. Goldsmith, Aylin R. Rodan…
Certain Environmental Chemicals Linked with Poor Kidney Health
• In an analysis of blood and urine samples from 46,748 US adults, elevated levels of 7 environmental chemicals were associated with markers of kidney disease.
Genetics May Determine Who Benefits from Broccoli’s Effects on Kidney Health
• Deletion of the gene that codes for an enzyme called GSTM1 increased kidney injury in mice with hypertension and kidney disease, but supplementing the diet with broccoli powder lessened kidney injury in the genetically altered mice.
• In humans, high consumption of broccoli and other cruciferous vegetables was linked with a lower risk of kidney failure, primarily in individuals lacking GSTM1.
Exploring How a Key Blood Pressure Hormone Works in Males and Females
Aldosterone is a steroid hormone important to the regulation of salt, fluid and potassium in the body. Researchers at the “Metabolic and sex differences in aldosterone responses” symposium will explore the growing body of research that finds sex is a major determinant of how aldosterone acts on the body.
Common Clinical Estimates of Kidney Function May Not Accurately Assess Indian Patients
Pilot study finds that considering body composition rather than weight could improve patient management Charlottesville, Va. (June 25, 2019)—A common metric for monitoring kidney health may not accurately represent the kidney function of Indian patients. However, tweaks to an older…
Baking Soda Boosts Immunity, Impairs Insulin Response in Type 2 Diabetes
Researchers learn insulin response connected to alkaline load, not inflammation Charlottesville, Va. (June 24, 2019)—Early research suggests that the common pantry staple baking soda affects inflammation and insulin handling in type 2 diabetes. The findings will be presented today at…
Blood Metabolite Levels May Help Identify Diabetic Kidney Disease
Noninvasive measurement may provide alternative to diagnostic kidney biopsy Charlottesville, Va. (June 24, 2019)—Metabolomics, the study of small molecules the body produces during metabolism (metabolites) may be a future key to identifying diabetes-related kidney disease. The finding will be presented…
Donald Kohan Details Recent Advances and New Frontiers in Kidney Research in Keynote Address
Charlottesville, Va. (June 23, 2019)—New treatments, exciting research and future trends in kidney health are the focus of discussion at the American Physiological Society (APS)/American Society of Nephrology (ASN) conference, Control of Renal Function in Health and Disease, in Charlottesville,…