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UrduThe fall is generally the start of flu season and when many of us get our annual flu vaccine. But what about bundling a flu vaccine with your COVID-19 shot? Earl Strum, MD, anesthesiologist and medical director of employee health…
Tag: Immunology
Pilar Alcaide, PhD, to Receive 2025 American Society for Investigative Pathology Outstanding Investigator Award
he 2025 recipient of the American Society for Investigative Pathology (ASIP) Outstanding Investigator Award is Dr. Pilar Alcaide, Kenneth and Jo Ann G. Wellner Professor, Director of Tufts Immunology Graduate Program, and Assistant Dean for Faculty Development in the Department of Immunology at the Tufts University School of Medicine.
LJI discovery paves the way for antivirals against Ebola virus and its deadly relatives
The new study, led by researchers in the Saphire Lab at LJI, reveals the inner workings of the Ebola virus nucleocapsid. LA JOLLA, CA—At this moment, the world has few tools to combat deadly filoviruses, such as Ebola and Marburg viruses. The only approved vaccine and antibody treatments protect against just one filovirus species.
Large-Scale Study Will Seek to Unearth Causes of Persistent Symptoms of Lyme Disease
Tufts University researchers have received a $20.7 million grant to lead the largest NIH-funded prospective study of patients with chronic Lyme disease to date, following patients from their earliest diagnosis to better identify why some people go on to develop debilitating symptoms later on.
Moffitt Researchers Reveal Key LAG3 Mechanisms That Could Transform Cancer Immunotherapy
Immune checkpoint inhibitors are a type of cancer treatment that helps the immune system attack cancer cells more effectively. One of the key proteins involved in this process is Lymphocyte Activation Gene-3 (LAG3), which suppresses the antitumor immune response.
UCLA receives $120 million from Alya and Gary Michelson for new California Institute for Immunology and Immunotherapy
UCLA has received a $120 million commitment from Dr. Gary Michelson and his wife, Alya, to kick-start the California Institute for Immunology and Immunotherapy, an innovative public-private partnership aimed at spurring breakthrough discoveries that prevent and cure diseases and catalyze economic growth and innovation in Los Angeles.
Cancer Research Institute Awards Over $22 Million in Grants to Fuel Immunotherapy Innovations
CRI awarded over $22 million to leading cancer immunotherapy researchers in the 2024 fiscal year, amounting to 64 awards at 42 institutions.
Announcing Stephen Jameson, Ph.D., as 2024-2025 President of the American Association of Immunologists
The American Association of Immunologists (AAI)
proudly announces Stephen Jameson, Ph.D., as its 2024-2025 president following his election to the office this past spring. Jameson, a distinguished immunologist, has been a member of the AAI Council since 2019 and will assume his new role on July 1, 2024.
Switching Decisions: Interleukin-12 Influences B Cell Immune Response
Researchers discover that a cytokine called interleukin-12 (IL-12) acts like a switch to direct which antibody response B cells will generate.
Roswell Park Insights on Role of Exportin 1 Protein Suggest Strategy for Improving Cancer Immunotherapy
Research by Hemn Mohammadpour, DVM, PhD, and colleagues at Roswell Park Comprehensive Cancer Center offers new insights into tumor biology and may lay the groundwork for more effective cancer immunotherapy. Their preclinical findings were published today in the journal Cellular & Molecular Immunology.
New research points to ‘stem-like’ T cells as culprits in ulcerative colitis
The researchers hope to one day target this T cell population via drug therapy. “These cells may be a very important target for treating ulcerative colitis and perhaps other autoimmune diseases…”
Emma Guttman-Yassky, MD, PhD, Receives High Honor at European Academy of Allergy and Clinical Immunology
The Paul Ehrlich Award for Experimental Research recognizes scientists who have revolutionized the understanding of allergic diseases and immunological mechanisms.
LJI scientists develop new method to match genes to their molecular ‘switches’
LA JOLLA, CA—Scientists at La Jolla Institute for Immunology (LJI) have developed a new computational method for linking molecular marks on our DNA to gene activity. Their work may help researchers connect genes to the molecular “switches” that turn them on or off. This research, published in Genome Biology, is an important step toward harnessing machine learning approaches to better understand links between gene expression and disease development.
Study Uncovers At Least One Cause of Roadblocks to Cancer Immunotherapy
A study led by Yale scientists, published April 25 in the journal Science Immunology, investigated the potential causes associated with T cell exclusion using a genome-wide screen of more than 1,000 human proteins.
The American Association of Immunologists Partners with Oxford University Press to Publish Preeminent Immunology Journals
The American Association of Immunologists (AAI) today announced its publishing partnership with Oxford University Press (OUP). OUP will publish the AAI journals, The Journal of Immunology (The JI) and ImmunoHorizons (IH), beginning in 2025.
American Association of Immunologists (AAI) Introduces New Brand Identity
Today the American Association of Immunologists (AAI), one of the world’s largest organizations of immunologists and scientists in related disciplines, is proud to announce the launch of its new brand identity.
Machine learning tool identifies rare, undiagnosed immune disorders through patients’ electronic health records
Researchers say a machine learning tool can identify many patients with rare, undiagnosed diseases years earlier, potentially improving outcomes and reducing cost and morbidity. The findings, led by researchers at UCLA Health, are described in Science Translational Medicine.
LJI home to new “Center of Excellence”
The Institute’s Flow Cytometry Core, which provides cutting-edge research services, has been named a BD Biosciences “Center of Excellence.” Along with this distinction, the LJI Flow Core has brought in a sophisticated instrument for immune cell research: the BD FACSDiscover™ S8 Cell Sorter.
Are All Types of Asthma the Same? Not by a Long Shot
May is Asthma and Allergy Awareness Month – the ideal time to get the word out on the different types of asthma, as well as the different triggers and treatments.
Wistar Scientists Identify Pro-aging ‘Sugar Signature’ in the Blood of People Living with HIV
Wistar’s Dr. Abdel-Mohsen has identified sugar abnormalities in the blood that may promote biological aging and inflammation in people living with HIV.
UT Southwestern scientists discover antiviral immune pathway
By focusing on a poxvirus protein, a team led by UT Southwestern Medical Center scientists has discovered an antiviral immune pathway that broadly fights a wide variety of viruses. Their findings, reported in Nature Microbiology, could eventually lead to new ways to prevent or treat viral infections or thwart autoimmune diseases.
AAI Announces Selection of 16 AAI Trainee Members as Major Symposium Speakers at the American Association of Immunologists’ IMMUNOLOGY2024™ Annual Conference
The American Association of Immunologists today announced the selection of Trainee Members as a Major Symposium speakers for the IMMUNOLOGY2024™ meeting – the premier immunology conference bringing together the best minds, sharing cutting-edge research, and providing opportunities to connect –to be held in Chicago May 3-7, 2024.
Nanoparticles developed at UTSW effectively fight tumors
A nanoparticle-based therapy developed by UT Southwestern Medical Center scientists stimulated an immune pathway that eradicated tumors in mouse models of various cancer types. Their findings, published in Science Immunology, offer a new way to potentially harness the power of the body’s immune system against cancer.
The American Association of Immunologists Announces Election of Association Officers and Committee Leadership
The American Association of Immunologists (AAI) is proud to announce the outcome of its recent elections, in which voting members of the association selected the officers and committee leaders who will guide the organization in the years ahead.
CHOP Researchers Discover Key Metabolic Process Responsible for Rapid Immune Responses
Researchers identified a key metabolite in cells that helps direct immune responses and explains at a single cell level why immune cells that most efficiently recognize pathogens, vaccines, or diseased cells grow and divide faster than other cells.
AAI Announces Esteemed 2024 Distinguished Fellows: Recognizing Excellence in Immunological Innovation and Leadership
Recognizing exceptional scientific contributions and noteworthy service to the American Association of Immunologists (AAI) and the wider immunology community, AAI announces its 2024 class of Distinguished Fellows.
LJI welcomes new faculty member Miguel Reina-Campos, Ph.D.
Cancer researcher Miguel Reina-Campos, Ph.D., has joined the faculty of La Jolla Institute for Immunology (LJI) as an Assistant Professor to lead the Laboratory of Tissue Immune Networks. His laboratory at LJI aims to investigate the basis of CD8+ T cell tissue immunity to improve life-saving cancer immunotherapies.
Long COVID linked to persistently high levels of inflammatory protein: a potential biomarker and target for treatments
SARS-CoV-2 triggers the production of the antiviral protein IFN-γ, which is associated with fatigue, muscle ache and depression. New research shows that in Long COVID patients, IFN-y production persists until symptoms improve, highlighting a potential biomarker and a target for therapies.
In Memoriam: Jonathan W. Uhr, M.D., renowned immunologist and longtime Chair of Microbiology
Jonathan W. Uhr, M.D., Professor Emeritus of Immunology at UT Southwestern Medical Center, who discovered how antibodies are made and developed a technique that led to the early detection of cancer cells, died Feb. 15. He was 96. Dr. Uhr was a member of the National Academy of Sciences and the American Academy of Arts and Sciences.
New Trial Highlights Incremental Progress Towards a Cure for HIV-1
A new clinical trial, led by clinicians and researchers at the UNC School of Medicine, show that the combination of the drug vorinostat and immunotherapy may modestly shrink the latent HIV reservoir, but more work needs to be done in the field to create a cure.
Renowned Immunologist Dr. Gary Koretzky to Receive AAI Lifetime Achievement Award Honoring Exceptional Contributions to Immunology
Recognizing the impact of his research and outstanding leadership in the field of immunology, Gary Koretzky, M.D., Ph.D., DFAAI (AAI ’92), will receive the American Association of Immunologists (AAI) Lifetime Achievement Award, the association’s highest honor, at the AAI annual conference IMMUNOLOGY2024TM, May 3-7 in Chicago.
Brain Protein’s Virus-Like Structure May Help Explain Cancer-Induced Memory Loss
In a rare but serious complication of cancer, the immune system can start attacking the brain, causing rapid memory loss. What triggers this was largely unknown. Now, researchers at University of Utah Health have found that some tumors can release a virus-like protein, kickstarting an out-of-control autoimmune reaction.
New technology makes cancer easier for immune system to find and destroy
A new technology to increase visibility of cancer cells to the immune system using CRISPR has been developed, and could lead to a new way to treat cancer.
Ursula Storb, immunologist and role model for women scientists, 1936-2023
Storb was a Professor in the Department of Molecular Genetics and Cell Biology for more than 29 years.
Jean-Laurent Casanova is Recipient of 2023 Maria I. New International Prize for Biomedical Research
The Icahn School of Medicine at Mount Sinai will award its 2023 Maria I. New International Prize for Biomedical Research to Jean-Laurent Casanova, MD, PhD, for revolutionizing our understanding of human infectious diseases through the discovery of genetic and immunological determinants that underpin both rare and common infectious illnesses. The prize honors medical pioneers in the tradition of Maria I. New, MD, a world-renowned researcher in pediatric genetic disorders with a special focus on endocrinology over her six-decade career. Dr. Casanova will receive a prize of $20,000 and will present the Maria I. New Distinguished Lecture during a ceremony to be held in at Icahn Mount Sinai in New York City on November 21, 2023.
American Association of Immunologists Congratulates Dr. Steven Rosenberg on Receiving the National Medal of Technology and Innovation
AAI celebrates an immunologist being given the National Medal of Technology and Innovation
Army of specialized T cells may trigger asthma attacks in older men
LA JOLLA, CA—Scientists from La Jolla Institute for Immunology (LJI) and The University of Southampton, UK, have uncovered a group of immune cells that may drive severe asthma. These cells, called cytotoxic CD4+ tissue-resident memory T cells, gather in the lungs and appear to possess the molecular weaponry to cause the most harm in men who developed asthma later in life.
Miriam Merad, MD, PhD, Elected to the National Academy of Medicine for Seminal Work in Immunology and Cell Biology
Miriam Merad, MD, PhD, an esteemed immunologist at the Icahn School of Medicine at Mount Sinai, has been elected to the National Academy of Medicine (NAM) in recognition of her pioneering contributions to the fields of immunology and cell biology.
World-first research breakthrough sparks new hope for bowel cancer patients
Every year, over 15,500 Australians are diagnosed with bowel cancer, and it is the second leading cause of cancer deaths in the country. Over 1,700 (one in ten) of those diagnosed are young Australians aged under 50, and this incidence is increasing.
Allergy study on ‘wild’ mice challenges the hygiene hypothesis
The notion that some level of microbial exposure might reduce our risk of developing allergies has arisen over the last few decades and has been termed the hygiene hypothesis.
Study offers way to increase immune checkpoint inhibitor effectiveness in patients with MTAP-deleted cancers
The deletion of MTAP is primarily responsible for the decline in T cell function and lack of response to immune checkpoint inhibitors in patients whose tumor cells lack working copies of this gene.
The American Association of Immunologists Announces 2023 Recipients of the Careers in Immunology Fellowships
The American Association of Immunologists awards thirteen principal investigators one year of salary support for trainees
The American Association of Immunologists Announces 2023 Recipients of the Travel for Techniques Awards Program
AAI awarded four scientists funds for trips to laboratories to learn new research techniques
Cell therapy can reduce risk of death from COVID-19 by 60%, study shows
The use of cell therapy to treat COVID-19 patients can reduce the risk of death from the disease by 60%, according to a systematic review and meta-analysis conducted by researchers at the University of São Paulo (USP) in Brazil, in partnership with colleagues in Germany and the United States.
UTSW researchers identify driver of inflammatory bowel disease
Researchers at UT Southwestern Medical Center have discovered an intracellular mechanism that converts protective intestinal cells into disease-driving pathogenic cells, a finding that could lead to improved treatments for patients with inflammatory bowel disease (IBD).
LJI scientists harness ‘helper’ T cells to treat tumors
La Jolla Institute for Immunology (LJI) scientists have published a pair of studies that show how we might harness CD4+ T cells while boosting the cancer-fighting power of CD8+ “killer” T cells.
Intestinal bacteria release molecular ‘brake’ on weight gain
Bacteria that live in the intestines inhibit a molecule that limits the amount of fat absorbed, increasing weight gain in mice fed a high-sugar, high-fat diet, researchers from UT Southwestern Medical Center report. The findings, published in Science, could eventually lead to new ways to combat obesity, diabetes, and malnutrition – health problems that plague hundreds of millions worldwide.
Rather than providing protection, an Omicron infection may leave patients more susceptible to future COVID infections, researchers find after studying seniors in care
Researchers at McMaster University have found that rather than conferring immunity against future infections, infection during the first Omicron wave of COVID left the seniors they studied much more vulnerable to reinfection during the second Omicron wave.
New LJI research has major implications for controlling T cell activity
According to new research in the journal Immunity, T cells have a nuclear receptor doing something very odd—but very important—to help them fight pathogens and destroy cancer cells.
Expert Available to Discuss Rise in Rare and Obscure Diseases
There’s been an uptick in the U.S. recently in relatively obscure and rare diseases — malaria, leprosy, measles –– making a comeback, with many in the health community sounding the alarm bells. Philadelphia College of Osteopathic Medicine’s Brian DeHaven, PhD, an expert in virology and immunology,…