CHOP Researchers Improve Fitness of Cells Used in Cell Transplants

A readily available, inexpensive small molecule drug can improve the fitness of hematopoietic stem and progenitor cells (HSPCs) that are modified outside of the body, potentially improving the success of procedures like ex vivo gene therapy, according to a new study by researchers at Children’s Hospital of Philadelphia (CHOP).

Researchers at UC San Diego Identify the Skin’s Master Regulator

Researchers led by George Sen, PhD, associate professor of dermatology and cellular and molecular medicine at UC San Diego School of Medicine, have identified the master regulator controlling the expression of genes regulating how the epidermis attaches to the underlying…

Researchers use lasers and molecular tethers to create perfectly patterned platforms for tissue engineering

University of Washington researchers developed a technique to modify naturally occurring biological polymers with protein-based biochemical messages to affect cell behavior. Their approach uses near-infrared lasers to trigger chemical adhesion of proteins to scaffolds made from biological polymers like collagen.

Predicting Cancer Behavior Requires Better Understanding of Tumor Cells

Our ability to predict who will get cancer, how patients will respond to treatment, or if patients will relapse is still quite limited, despite advances in the detection of genetic mutations and the establishment of risk factors; recently researchers were inspired to find new ways of looking at the problem. In Biomicrofluidics, they report that using cellular mechanophenotyping, along with traditional methods such as immunostaining and genetic analysis, may provide a more comprehensive view of a tumor.