A team of researchers led by a biomedical scientist at the University of California, Riverside, has identified a novel mechanism by which loss-of-function mutations in the gene PTPN2, found in many patients with inflammatory bowel disease, or IBD, affect how intestinal epithelial cells maintain a barrier.
Patients with inflammatory bowel diseases (IBD) do not appear to have increased risk of side effects from the Pfizer or Moderna COVID-19 vaccines, according to a recent Cedars-Sinai study published online and upcoming in print in the American Journal of Gastroenterology. In fact, those being treated with advanced immune-modifying therapies may experience them less often than the general population.
A new study published in Nature Communications demonstrates that a consortium of bacteria designed to complement missing or underrepresented functions in the imbalanced microbiome of inflammatory bowel disease (IBD) patients, prevented and treated chronic immune-mediated colitis in humanized mouse models.
Article title: Role of perivascular nerve and sensory neurotransmitter dysfunction in inflammatory bowel disease Authors: Charles E. Norton, Elizabeth A. Grunz-Borgmann, Marcia L. Hart, Benjamin W. Jones, Craig L. Franklin, Erika M. Boerman From the authors: “Our study is the…
Irritable bowel syndrome (IBS) is the most common gastrointestinal disorder, affecting 10-15% of the world’s population. Approximately two-thirds of those who suffer from IBS are women. The disease can have mild forms or cause severe debilitation as diarrhea alternates with constipation. Severe cramping and bloating also are common. Because chronic IBS is so debilitating, it often disrupts the daily lives of people with this disorder.
At the beginning of an immune response, a molecule known to mobilize immune cells into the bloodstream, where they home in on infection sites, rapidly shifts position, a new study shows. Researchers say this indirectly amplifies the attack on foreign microbes or the body’s own tissues.
A surgical procedure meant to counter ulcerative colitis, an immune disease affecting the colon, may trigger a second immune system attack, a new study shows.
New study illustrates how studying diverse populations can help predict patient outcomes and reduce health disparities
Maria T. Abreu, M.D., a renowned gastroenterologist at the University of Miami Miller School of Medicine, was honored with the “Lifetime Disruptor” award at the American College of Gastroenterology’s 2020 virtual meeting.
Blood clots are the biggest cause of death in patients with inflammatory bowel disease (IBD) ─ ulcerative colitis or Crohn’s disease. In a retrospective study recently published in the journal Gastroenterology, Cedars-Sinai investigators found that a combination of rare and common genetic variants in some IBD patients significantly increased their risk of developing clot-causing thromboembolic diseases.
Using sophisticated 3D genomic mapping and integrating with public data resulting from genome-wide association studies (GWAS), researchers at Children’s Hospital of Philadelphia (CHOP) have found significant genetic correlations between inflammatory bowel disease (IBD) and stress and depression. The researchers went on to implicate new genes involved in IBD risk that are enriched in both derived hypothalamic neurons, from a part of the brain that has a vital role in controlling stress and depression, and organoids derived from colon cells, a region more commonly studied in the context of IBD.
DALLAS – Oct. 28, 2020 – Mice fed diets high in sugar developed worse colitis, a type of inflammatory bowel disease (IBD), and researchers examining their large intestines found more of the bacteria that can damage the gut’s protective mucus layer.
A personalized program to increase resilience in patients with inflammatory bowel disease (IBD) can substantially reduce hospitalizations and emergency room visits, Mount Sinai researchers report. The research is being unveiled on October 27th in a plenary presentation at the annual scientific meeting of the American College of Gastroenterology (ACG 2020).
Cedars-Sinai researchers might have solved a mystery surrounding Crohn’s disease: Why does fat appear to migrate into patients’ small intestines?
Researchers at UC San Diego School of Medicine report that the lasting nature of inflammatory bowel disease may be due to a type of long-lived immune cell that can provoke persistent, damaging inflammation in the intestinal tract.
UC Davis researchers have found that combining a Western-style high-fat diet with antibiotic use significantly increases the risk of developing pre- inflammatory bowel disease. This combination shuts down the mitochondria in cells of the colon lining, leading to gut inflammation. Mesalazine can help restart the mitochondria and treat pre-IBD condition.
A new study published in Clinical Gastroenterology and Hepatology led by Maria T. Abreu, M.D., professor of medicine and professor of microbiology and immunology at the University of Miami Miller School of Medicine, found that eating diets low in fat and high in fiber may improve the quality of life of patients with ulcerative colitis (UC) — even those in remission.
A new study describes how poor oral health may worsen gut inflammation.
A systematic review and meta-analysis has determined there is a nine-fold increased risk of having IBD for patients with a previous diagnosis of celiac disease. Similarly, the risk for celiac disease is increased in IBD patients, though to a smaller extent.
In a series of four studies published today in Gastroenterology, a journal of the American Gastroenterological Association, Mount Sinai inflammatory bowel disease (IBD) researchers, describe the identification of predictive tools and a new understanding of environmental factors that trigger IBD.
Investigators at the Case Western Reserve University School of Medicine discovered that blocking interleukin-1α (IL1α), a protein that controls inflammation in the gut, markedly decreases the severity of intestinal inflammation in a mouse model of Crohn’s disease (CD).
In a finding that could help lead to new therapies for immune diseases like multiple sclerosis and IBD, scientists report in the Journal of Experimental Medicine identifying a gene and family of proteins critical to the formation of mature and fully functioning T cells in the immune system.