Stem Cell | sciencenewsnet.in

First time in Thailand – Chula Successfully Uses Stem-cell Transplantation to Treat Systemic Sclerosis Patients with Pulmonary Fibrosis

May 4, 2021 sarah Jonas Fibrosis, healthcare innovation, Pulmonary Fibrosis, Rheumatology, Stem Cell, Stem Cell Transplantation, systemic sclerosis

April 8, 2021 – The Division of Rheumatology, Department of Medicine, Faculty of Medicine (CU Medi), Chulalongkorn University and King Chulalongkorn Memorial Hospital, the Thai Red Cross Society (Chulalongkorn Hospital), in collaboration with the Departments of Hematology, Pulmonary and Critical Care Medicine, and Infectious diseases, held a press conference on “Thailand’s first successful treatment of systemic sclerosis patients with pulmonary fibrosis by stem cell transplantation“.

Research Results

Potential Target for Treating Many Cancers Found Within GLI1 Gene

March 1, 2021 sarah Jonas Cancer, CRISPR, Oncogene, Stem Cell

Scientists from the Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago found that a region within the DNA of the cancer-promoting GLI1 gene is directly responsible for regulating this gene’s expression. These findings, published in the journal Stem Cells, imply that this region within GLI1 could potentially be targeted as cancer treatment, since turning off GLI1 would interrupt excessive cell division characteristic of cancer.

Rush University Medical Center to Hold Screening for Documentary, Feb. 24

February 22, 2021 sarah Jonas Brain Health, Clinical Trials, Documentary, Neurosurgeon, Regenerative Research, Research, Stem Cell

Rush University Medical Center will hold a virtual screening and panel discussion of a new documentary about regenerative research that features surgeon and researcher Richard Fessler, MD, PhD.

Research Results

Scientists Take Important Step Toward Using Retinal Cell Transplants to Treat Blindness

January 14, 2021 sarah Jonas Blind, Blindness, Cell Therapy, Donor, Icahn School of Medicine at Mount Sinai, Macular Degeneration, Mount Sinai Health System, Retina, Retina disease, retinal cells, Retinal Disease, Stem Cell, Stem Cell Therapy

Retinal cells derived from a cadaver human eye survived when transplanted into the eyes of primate models, an important advance in the development of cell therapy to treat blindness, according to a study published on January 14 in Stem Cell Reports.

Girl gets her smile back – and a new jaw – thanks to innovative tissue engineering procedure

December 17, 2020 sarah Jonas Stem Cell, Surgery, The University of Texas Health Science at Houston (UTHealth), Tumor, UTHealth School of Dentistry

Nine-year-old Grace Moss of Laredo, Texas, was facing a daunting prospect. A tumor that had invaded her jaw had been removed, but now the plastic surgeon wanted to remove her fibula – the smaller of the two bones in her lower leg – to use as a graft.

New Cedars-Sinai Biomanufacturing Center to Spur Cell Therapies

December 4, 2020 sarah Jonas Cedars-Sinai, Clive Svendsen, Gene Therapy, Stem Cell

Cedars-Sinai has launched a center to manufacture the next generation of stem cell and gene therapies that will enable biomedical researchers, government medical programs, commercial entities and others to develop new biologic drugs and propel novel disease discoveries.

Satellite Stem Cells Required for Normal Muscle Response to Exercise

December 2, 2020 sarah Jonas Exercise, genes, Muscle Cells, Physiology, satellite cells, Stem Cell

A new study in mice published in the journal Function finds that a lack of satellite cells—stem cells that become

Research Results

Study reveals how smoking worsens COVID-19 infection in the airways

November 17, 2020 sarah Jonas COVID-19, lung, Lung Health, Smoking, Stem Cell

UCLA researchers using a model of airway tissue created from human stem cells have pinpointed how smoking cigarettes causes more severe infection by SARS-CoV-2, the virus that causes COVID-19, in the airways of the lungs.

Research Results

New research reveals why low oxygen damages the brain

October 21, 2020 sarah Jonas Brain, Cerebal Palsy, Hypoxia, Multiple Sclerosis (MS), Stem Cell, Stroke

Brain cell dysfunction in low oxygen is, surprisingly, caused by the very same responder system that is intended to be protective, according to a new published study by a team of researchers at the Case Western Reserve University School of Medicine.

Research Tip Sheet

Agricultural Toxicity, Hepatic Effects of Phenobarbital, and More Featured in October 2020 Toxicological Sciences

October 15, 2020 sarah Jonas Agricultural, Agriculture, Arsenic, Brazil, Cytoskeleton, Extracellular Matrix, Hepatic, mice, Microtubules, Phenobarbital, Receptor, Society Of Toxicology, Stem Cell, Toxicity, toxicological sciences, TOXICOLOGY, toxsci

Toxicological Sciences features leading research biotransformation, toxicokinetics, and pharmacokinetics; computational toxicology and databases; mixtures toxicology; and more in the October 2020 issue.

Research Results

Researchers Discover Stem Cells in Optic Nerve that Preserve Vision

July 30, 2020 sarah Jonas Glaucoma, Opthalmalogy, Stem Cell

Researchers at the University of Maryland School of Medicine (UMSOM) have for the first time identified stem cells in the region of the optic nerve, which transmits signals from the eye to the brain. The finding presents a new theory on why the most common form of glaucoma may develop and potential for new therapies.

Research Results

A simpler way to make sensory hearing cells

July 1, 2020 sarah Jonas Hearing, Stem Cell, USC

USC Stem Cell scientists have pioneered a simpler way to generate the sensory cells of the inner ear. The study was published in the journal eLife.

Research Results

Discovery in Acute Myeloid Leukemia Could Provide Novel Pathway for New Treatments

June 2, 2020 sarah Jonas Leukemia, Mount Sinai Health System, Stem Cell, The Tisch Cancer Institute

Researchers at Mount Sinai have discovered that human acute myeloid leukemia (AML) stem cells are dependent on a transcription factor known as RUNX1, potentially providing a new therapeutic target to achieve lasting remissions or even cures for a disease in which medical advances have been limited.

Research Results

Lab-Grown Miniature Human Livers Successfully Transplanted in Rats

June 2, 2020 sarah Jonas LIVER, Stem Cell, Transplant

Using skin cells from human volunteers, researchers at the University of Pittsburgh School of Medicine have created fully functional mini livers, which they then transplanted into rats. In this proof-of-concept experiment, the lab-made organs survived for four days inside their animal hosts.

Research Results

Stem Cell Treatments ‘Go Deep’ to Regenerate Sun-Damaged Skin

May 28, 2020 sarah Jonas Plastic and Reconstructive Surgery®, Stem Cell

For a while now, some plastic surgeons have been using stem cells to treat aging, sun-damaged skin. But while they’ve been getting good results, it’s been unclear exactly how these treatments – using adult stem cells harvested from the patient’s own body – work to rejuvenate “photoaged” facial skin.

Research Results

Image Analysis Technique Provides Better Understanding of Heart Cell Defects

May 19, 2020 sarah Jonas Algorithm, Biophysics, Cardio, Cardiomyocytes, Heart Cells, Heart Disease, Journal of Applied Physics, Physics, Stem Cell, University of Wisconsin-Madison

Many patients with heart disease face limited treatment options. Fortunately, stem cell biology has enabled researchers to produce large numbers of cardiomyocytes, which may be used in advanced drug screens and cell-based therapies. However, current image analysis techniques don’t allow researchers to analyze heterogeneous, multidirectional, striated myofibrils typical of immature cells. In the Journal of Applied Physics, researchers showcase an algorithm that combines gradient methods with fast Fourier transforms to quantify myofibril structures in heart cells with considerable accuracy.

Research Results

UCLA scientists create first roadmap of human skeletal muscle development

May 11, 2020 sarah Jonas Stem Cell

An interdisciplinary team of researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at UCLA has developed a first-of-its-kind roadmap of how human skeletal muscle develops, including the formation of muscle stem cells.

University of Miami Treats COVID-19 Patients with MSC Stem Cells

April 27, 2020 sarah Jonas covid 19, Inflammation, Innovation, Research & Development, Respiratory, Stem Cell

For COVID-19 patients in severe respiratory distress, the University of Miami Miller School of Medicine now offers access to mesenchymal

UCLA scientists receive grants for COVID-19 research from California’s stem cell agency

April 24, 2020 sarah Jonas Cirm, COVID-19, Stem Cell, UCLA

Three researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have received awards to pursue treatments and vaccines for COVID-19 from the California Institute for Regenerative Medicine, the state’s stem cell agency.

Coriell Institute for Medical Research Awarded $8.6 Million Biobanking Contract from National Institute on Aging

March 18, 2020 sarah Jonas Aging, Biobank, biobanking, coriell institute, coriell institute for medical research, Induced Pluripotent Stem Cells, iPSC, National Institute On Aging, NIH Award, Stem Cell

The newly awarded $8.6 million funding keeps Coriell in place as the trusted steward of this collection and includes the addition of new innovative products to expand the collection. The NIA Aging Cell Repository was established at Coriell in 1974 and Coriell has continuously managed this unique resource ever since.

Research Results

Inhalation Therapy Shows Promise Against Pulmonary Fibrosis in Mice, Rats

February 28, 2020 sarah Jonas Mouse Model, Stem Cell

A new study shows that lung stem cell secretions – specifically exosomes and secretomes – delivered via nebulizer, can help repair lung injuries due to multiple types of pulmonary fibrosis in mice and rats.

Research Results

Mount Sinai Researchers Discover New Approach for Use of Stem Cells to Improve Bone Marrow Transplantation

February 27, 2020 sarah Jonas Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, Science, Stem Cell

Mount Sinai researchers have discovered a way to enhance the potency of blood-forming stem cells, potentially opening the door to a new approach for bone marrow transplantation.

Research Results

UCLA researchers discover new compound that promotes lung health

February 18, 2020 sarah Jonas Airway, Cancer, lung, Lung Cancer, Stem Cell

A molecule identified by UCLA researchers helps maintain a healthy balance of cells in airway and lung tissue. If the compound, so far only studied in isolated human and mouse cells, has the same effect in people, it may lead to new drugs to treat or prevent lung cancer.

Proper heart development all about timing

February 13, 2020 sarah Jonas pediatric cardiology, Stem Cell, University of Chicago Medicine

The University of Chicago Medicine’s Ivan Moskowitz, MD, PhD, and his team are studying why some cells develop into their adult forms more quickly than others, and how issues with that timing can lead to congenital heart disease.

Research Results

CDI Lab Explores Pathway to Open up Blood Cancer Treatments

February 12, 2020 sarah Jonas Bone Marrow, Cancer, Stem Cell

The CDI team’s findings could ultimately improve cancer treatments for people of advanced age, like that of adult acute myeloid leukemia (AML)

Allen Institute for Cell Science Extends Agreement with Coriell Institute for Medical Research

February 3, 2020 sarah Jonas coriell institute, coriell institute for medical research, CRISP/Cas9, Induced Pluripotent Stem Cells, Stem Cell, Stem Cells

The Allen Institute has extended its contract with the Coriell Institute for Medical Research for the storage and distribution of its Allen Cell Collection, a cutting-edge collection of gene-edited human induced pluripotent stem cell lines. This collection was launched in 2016 with five cell lines, and since has grown to include more than 40 lines. The new agreement will continue this relationship for an additional three years.

Research Results

Six patients with rare blood disease are doing well after gene therapy clinical trial

January 28, 2020 sarah Jonas 0 Comments Blood Disorders, Blood Stem Cells, Chronic granulomatous disease, Clinical Trial, Gene Therapy, Stem Cell

UCLA researchers are part of an international team that reported the use of a stem cell gene therapy to treat nine people with the rare, inherited blood disease known as X-linked chronic granulomatous disease, or X-CGD. Six of those patients are now in remission and have stopped other treatments. Before now, people with X-CGD – which causes recurrent infections, prolonged hospitalizations for treatment, and a shortened lifespan – had to rely on bone marrow donations for a chance at remission.

Research Results

Researchers create accurate model of organ scarring using stem cells in a lab

December 10, 2019 sarah Jonas 0 Comments Stem Cell

A team led by Dr. Brigitte Gomperts at UCLA has developed a “scar in a dish” model that uses multiple types of cells derived from human stem cells to closely mimic the progressive scarring that occurs in human organs. The researchers used this model to identify a drug candidate that stopped the progression of and even reversed fibrosis in animal models.

Research Results

New Mayo Clinic studies to be presented at American Society of Hematology meeting

December 9, 2019 sarah Jonas 0 Comments American Society Of Hematology, Cancer, Leukemia, Medical Research, Multiple Myeloma, Stem Cell

Mayo Clinic researchers will present findings at the American Society of Hematology Annual Meeting Dec. 7–10 in Orlando.
New Mayo Clinic studies to be presented include:
DNA analysis identifies elevated risk factor for myeloma in individuals of African ancestry
Study identifies more precise assessment measures for patients newly diagnosed with chronic lymphocytic leukemia
Researchers develop method to assess cancer-fighting cell therapy’s effectiveness

Research Results

Researchers identify protein that governs human blood stem cell self-renewal

November 27, 2019 sarah Jonas 0 Comments Cancer, Stem Cell

UCLA scientists have discovered a link between a protein and the ability of human blood stem cells to self-renew. In a study published today in the journal Nature, the team reports that activating the protein causes blood stem cells to self-renew at least twelvefold in laboratory conditions

Stem Cells Don’t Take the Day Off on Thanksgiving

November 22, 2019 sarah Jonas 0 Comments Stem Cell

While most of us are enjoying the traditional turkey and pumpkin pie on Thanksgiving Day, employees at Cedars-Sinai will be hand-feeding stem cells their special daily formula, carefully monitoring the incubator temperatures and caring for the cells that may become part of important research that could one day lead to treatments for diseases that have plagued humans for years.

Guarding against a devastating tropical disease

November 13, 2019 sarah Jonas 0 Comments Basic Science, Parasite, regenerative biology, Schistosomiasis, Stem Cell

Schistosomiasis is one of the most devastating tropical diseases in the world, second only to malaria in its prevalence. The only treatment currently used is extremely limited in its effectiveness and in who it can help. The Newmark Lab wants to develop something that protects people from being infected in the first place.

‘It’s not about just surviving. It’s about seeing my patients living normally’

November 12, 2019 sarah Jonas 0 Comments Cancer, Leukemia, Stem Cell, Stem Cell Transplant, Stem Cell Transplantation

Dr. Eugene Chang was 25, recently engaged and halfway through a physical medicine and rehabilitation residency in Vancouver when he started feeling sick. Fatigue, dizziness and nausea took over his normally active lifestyle. Suddenly his bike to work was not so easy.

Three UCLA scientists receive grants totaling more than $18 million

October 31, 2019 sarah Jonas 0 Comments Cancer, CAR T cell therapy, Stem Cell

Three researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have received awards totaling more than $18 million from the California Institute for Regenerative Medicine, the state’s stem cell agency.

Research Results

Tapeworms need to keep their head to regenerate

September 24, 2019 sarah Jonas 0 Comments Parasite, Stem Cell

Scientists show that the location of stem cells is essential in determining tapeworms’ ability to regenerate.

Research Results

Stem Cells With ‘Dual Identity’ Linked to Loss of Smell From Sinus Inflammation

September 19, 2019 sarah Jonas 0 Comments Stem Cell

In experiments with mice and human tissue samples, Johns Hopkins Medicine researchers report evidence that neuronal stem cells in the part of the nose responsible for the sense of smell transform themselves to perpetuate the long-term inflammation in chronic sinusitis.

Research Results

A Snapshot in Time: Study Captures Fleeting Cell Differences That Can Alter Disease Risk

June 27, 2019March 13, 2020 sarah Jonas 0 Comments Cell Differentiation, Gene Expression, Gene Expression Analysis, genes, heart muscle, Stem Cell

In cinema and science fiction, one small change in the past can have major, sometimes life-changing effects in the future.