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Potential Target for Treating Many Cancers Found Within GLI1 Gene

March 1, 2021 sarah Jonas Cancer, CRISPR, Oncogene, Stem Cell

Scientists from the Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago found that a region within the DNA of the cancer-promoting GLI1 gene is directly responsible for regulating this gene’s expression. These findings, published in the journal Stem Cells, imply that this region within GLI1 could potentially be targeted as cancer treatment, since turning off GLI1 would interrupt excessive cell division characteristic of cancer.

Feature

Rush University Medical Center to Hold Screening for Documentary, Feb. 24

February 22, 2021 sarah Jonas Brain Health, Clinical Trials, Documentary, Neurosurgeon, Regenerative Research, Research, Stem Cell

Rush University Medical Center will hold a virtual screening and panel discussion of a new documentary about regenerative research that features surgeon and researcher Richard Fessler, MD, PhD.

Research Results

Scientists Take Important Step Toward Using Retinal Cell Transplants to Treat Blindness

January 14, 2021 sarah Jonas Blind, Blindness, Cell Therapy, Donor, Icahn School of Medicine at Mount Sinai, Macular Degeneration, Mount Sinai Health System, Retina, Retina disease, retinal cells, Retinal Disease, Stem Cell, Stem Cell Therapy

Retinal cells derived from a cadaver human eye survived when transplanted into the eyes of primate models, an important advance in the development of cell therapy to treat blindness, according to a study published on January 14 in Stem Cell Reports.

Feature

Girl gets her smile back – and a new jaw – thanks to innovative tissue engineering procedure

December 17, 2020 sarah Jonas Stem Cell, Surgery, The University of Texas Health Science at Houston (UTHealth), Tumor, UTHealth School of Dentistry

Nine-year-old Grace Moss of Laredo, Texas, was facing a daunting prospect. A tumor that had invaded her jaw had been removed, but now the plastic surgeon wanted to remove her fibula – the smaller of the two bones in her lower leg – to use as a graft.

Announcement

New Cedars-Sinai Biomanufacturing Center to Spur Cell Therapies

December 4, 2020 sarah Jonas Cedars-Sinai, Clive Svendsen, Gene Therapy, Stem Cell

Cedars-Sinai has launched a center to manufacture the next generation of stem cell and gene therapies that will enable biomedical researchers, government medical programs, commercial entities and others to develop new biologic drugs and propel novel disease discoveries.

Research Alert

Satellite Stem Cells Required for Normal Muscle Response to Exercise

December 2, 2020 sarah Jonas Exercise, genes, Muscle Cells, Physiology, satellite cells, Stem Cell

A new study in mice published in the journal Function finds that a lack of satellite cells—stem cells that become

Research Results

Study reveals how smoking worsens COVID-19 infection in the airways

November 17, 2020 sarah Jonas COVID-19, lung, Lung Health, Smoking, Stem Cell

UCLA researchers using a model of airway tissue created from human stem cells have pinpointed how smoking cigarettes causes more severe infection by SARS-CoV-2, the virus that causes COVID-19, in the airways of the lungs.

Research Results

New research reveals why low oxygen damages the brain

October 21, 2020 sarah Jonas Brain, Cerebal Palsy, Hypoxia, Multiple Sclerosis (MS), Stem Cell, Stroke

Brain cell dysfunction in low oxygen is, surprisingly, caused by the very same responder system that is intended to be protective, according to a new published study by a team of researchers at the Case Western Reserve University School of Medicine.

Research Tip Sheet

Agricultural Toxicity, Hepatic Effects of Phenobarbital, and More Featured in October 2020 Toxicological Sciences

October 15, 2020 sarah Jonas Agricultural, Agriculture, Arsenic, Brazil, Cytoskeleton, Extracellular Matrix, Hepatic, mice, Microtubules, Phenobarbital, Receptor, Society Of Toxicology, Stem Cell, Toxicity, toxicological sciences, TOXICOLOGY, toxsci

Toxicological Sciences features leading research biotransformation, toxicokinetics, and pharmacokinetics; computational toxicology and databases; mixtures toxicology; and more in the October 2020 issue.

Research Results

Researchers Discover Stem Cells in Optic Nerve that Preserve Vision

July 30, 2020 sarah Jonas Glaucoma, Opthalmalogy, Stem Cell

Researchers at the University of Maryland School of Medicine (UMSOM) have for the first time identified stem cells in the region of the optic nerve, which transmits signals from the eye to the brain. The finding presents a new theory on why the most common form of glaucoma may develop and potential for new therapies.

Research Results

A simpler way to make sensory hearing cells

July 1, 2020 sarah Jonas Hearing, Stem Cell, USC

USC Stem Cell scientists have pioneered a simpler way to generate the sensory cells of the inner ear. The study was published in the journal eLife.

Research Results

Discovery in Acute Myeloid Leukemia Could Provide Novel Pathway for New Treatments

June 2, 2020 sarah Jonas Leukemia, Mount Sinai Health System, Stem Cell, The Tisch Cancer Institute

Researchers at Mount Sinai have discovered that human acute myeloid leukemia (AML) stem cells are dependent on a transcription factor known as RUNX1, potentially providing a new therapeutic target to achieve lasting remissions or even cures for a disease in which medical advances have been limited.

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