Gene variants may increase susceptibility to accumulate Alzheimer’s protein tau, study shows

The toxic protein tau is a key biological feature in the brains of people with Alzheimer’s disease. Yet the factors that make people susceptible or resistant to tau accumulation are not well-understood. A preliminary Mayo Clinic study shows that inherited DNA variants may be associated with developing tau deposits in older adults. The research will be presented at the American Academy of Neurology’s 72nd Annual Meeting in Toronto April 25–May 1.

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Activating immune cells could revitalize the aging brain, study suggests

Researchers at Albany Medical College in New York have discovered that a specific type of immune cell accumulates in older brains, and that activating these cells improves the memory of aged mice. The study, which will be published February 5 in the Journal of Experimental Medicine (JEM), suggests that targeting these cells might reduce age-related cognitive decline and combat aging-associated neurodegenerative disease in humans.

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Expert Alert: Keep exercising: New study finds it’s good for your brain’s gray matter

A study in Mayo Clinic Proceedings from the German Center for Neurodegenerative Diseases provides new evidence of an association between cardiorespiratory fitness and brain health, particularly in gray matter and total brain volume — regions of the brain involved with cognitive decline and aging.

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