Study Reveals How Obesity Could Accelerate Aging in the Brain

A new study conducted in mice traces how obesity and a high-fat diet may accelerate aging in the blood vessels that supply blood to the brain. The work is being presented this week at the American Physiology Summit, the flagship annual meeting of the American Physiological Society.

High fat diet activates early inflammation in mouse brains, supports link to neurologic disease

Researchers at Michigan Medicine have discovered that a high-fat diet promotes an early inflammatory response in the brains of mice through an immune pathway linked to diabetes and neurologic diseases, suggesting a possible bridge between metabolic dysfunction and cognitive impairment.

Vitamin B5 May Help Weight Loss by Turning on Brown Fat

Pantothenate acid, also known as vitamin B5, stimulated the production of brown fat in both cell cultures and mice, a new study finds. “[B5] has therapeutic potential for treating obesity and type II diabetes,” researchers conclude. The study was chosen as an APSselect article for July.

Study: Obesity raises the risk of gum disease by inflating growth of bone-destroying cells

Chronic inflammation caused by obesity may trigger the development of cells that break down bone tissue, including the bone that holds teeth in place, according to new University at Buffalo research that sought to improve understanding of the connection between obesity and gum disease.

How high-fat diets allow cancer cells to go unnoticed

A high-fat diet increases the incidence of colorectal cancer. Cold Spring Harbor Laboratory Fellow Semir Beyaz and collaborators from Harvard Medical School and Massachusetts Institute of Technology have discovered that in mice, fat disrupts the relationship between intestinal cells and the immune cells that patrol them looking for emerging tumors.

Study Suggests Low-carbohydrate, High-fat Diet Protects against Obesity

Article title: Dietary carbohydrates modulate metabolic and β-cell adaptation to high-fat diet-induced obesity Authors: Tracy K. Her, William S. Lagakos, Matthew R. Brown, Nathan K. LeBrasseur, Kuntol Rakshit, Aleksey V. Matveyenko From the authors: “These studies support the hypothesis that low carbohydrate/high…

Lack of Sodium Channel Component Protects against Diet-induced Artery Stiffening

Article title: Western diet induces renal artery endothelial stiffening that is dependent on the epithelial Na+ channel Authors: Yuxin Xiong, Annayya R. Aroor, Francisco I. Ramirez-Perez, Guanghong Jia, Javad Habibi, Camila Manrique-Acevedo, Guido Lastra, Donqqing Chen, Vincent G. DeMarco, Luis A.…