Loss of Enzyme in Fat Tissue Leads to Improved Insulin Sensitivity in Liver

Article title: DPP4 deletion in adipose tissue improves hepatic insulin sensitivity in diet-induced obesity

Authors: Tania Romacho, Henrike Sell, Ira Indrakusuma, Diana Roehrborn, Tamara R. Castañeda, Tomas Jelenik, Daniel Markgraf, Sonja Hartwig, Jürgen Weiß, Hadi Al-Hasani, Michael Roden, Jürgen Eckel

From the authors: “Taken together, circulating [dipeptidyl peptidase 4 (DPP4)] is upregulated in obese rodents, and its downregulation improves hepatic insulin resistance likely by modulating insulin-like growth factor-binding protein 3, rendering adipose DPP4 as a new therapeutic target in hepatic insulin resistance.”

This study is highlighted as one of March’s “best of the best” as part of the American Physiological Society’s APSselect program.

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