Lack of Sodium Channel Component Protects against Diet-induced Artery Stiffening

Article title: Western diet induces renal artery endothelial stiffening that is dependent on the epithelial Na+ channel

Authors: Yuxin Xiong, Annayya R. Aroor, Francisco I. Ramirez-Perez, Guanghong Jia, Javad Habibi, Camila Manrique-Acevedo, Guido Lastra, Donqqing Chen, Vincent G. DeMarco, Luis A. Martinez-Lemus, Michael A. Hill, Frederic Jaisser, James R. Sowers, Adam Whaley-Connell

From the authors: “These results demonstrate that cell-specific EnNaC is important in propagating pulsatility into the renal circulation, generating oxidant stress, reduced bioavailable [nitric oxide], and renal vessel wall fibrosis and stiffening.”

This study is highlighted as one of June’s “best of the best” as part of the American Physiological Society’s APSselect program.

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