Researchers at Washington University School of Medicine in St. Louis have genetically engineered cells that, when implanted in mice, deliver a biologic drug in response to inflammation.
Research published ahead of print in the journal Function finds sodium prompts the release of regenerative factors in articular cartilage that has sustained injury due to osteoarthritis. Osteoarthritis causes a loss of the protein aggrecan that is an integral part…
When Lorry Graham needed multiple joint replacement surgeries for severe arthritis pain, she turned to Dr. Geoffrey Westrich at Hospital for Special Surgery. Mrs. Graham, who jokingly refers to herself as a “bionic woman,” and Dr. Westrich explain what to expect and give advice for the best outcome.
Nanofiber-based treatments stimulate the body to mount its own biological attack on immune disorders.
An international team of researchers, led by UC Davis Health, developed a new therapeutic approach to treating psoriatic arthritis, a chronic inflammatory disease affecting the joints.
Envisioning an animal-free drug supply, scientists have — for the first time — reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals and nutraceuticals.
A repurposed drug used to treat arthritis did not significantly improve the outcomes of patients with severe COVID-19 pneumonia. Tocilizumab did not significantly improve clinical status or mortality rate at 28 days for participants who received it compared to a placebo.
Just over 200,000 Americans suffer from systemic lupus erythematosus, or SLE, a condition in which the body’s immune system mistakenly attacks its own healthy tissues, especially joints and skin, a new study shows.
A Long Island dad wanted to dance with his daughter at her wedding, and he wasn’t going to let the pandemic or hip arthritis stop him. He had a hip replacement at Hospital for Special Surgery.
A study from investigators at Hospital for Special Surgery (HSS) and Brigham and Women’s Hospital in Boston has found that the synovial fluid and blood of people experiencing checkpoint inhibitor-induced arthritis is populated by a type of T cells rarely seen in people with other types of inflammatory arthritis. The findings are being presented at the virtual American College of Rheumatology annual meeting.
Children with arthritis affecting five or more joints, called polyarticular juvenile idiopathic arthritis (polyarticular JIA), living in less affluent families were twice as likely to report more than an hour of morning joint stiffness, compared to their counterparts from more affluent families, according to a study by investigators at Hospital for Special Surgery (HSS). Parents and physicians should be aware that morning joint stiffness may indicate early disease symptoms of polyarticular JIA and serve as a more reliable indicator than pain.
One in five Canadian adults is currently living with arthritis, a disease causing inflammation of the joints, which can result in chronic, debilitating pain, reduced mobility and premature disability. Arthritis is the leading cause of disability globally. To address this growing crisis, the Schroeder Arthritis Institute, launched with a $25 million donation by philanthropists Walter and Maria Schroeder, will help UHN’s innovative arthritis program become a world-class hub for innovation in research, education and patient care.
Researchers have created a machine-learning algorithm that can pick up on subtle signs of osteoarthritis – too abstract to register in the eye of a trained radiologist – on an MRI scan taken years before symptom onset.
A Keck Medicine of USC study reveals that kappa opioids, a significantly less addictive opioid, may preserve cartilage in joints and ease pain
Cappuccino, latte or short black, coffee is one of the most commonly consumed drinks in the world. But whether it’s good or bad for your health can be clarified by genetics, as a world-first study from the University of South Australia’s Australian Centre for Precision Health shows that excess coffee consumption can cause poor health.
UC San Diego Health has launched a Phase III clinical trial to assess whether a medication used to treat rheumatoid might also have therapeutic value for patient with COVID-19 who have developed or are at high risk of developing serious lung damage from SARS-CoV-2 infections.
Advances in knee replacement surgery, such as robotic-assisted surgery and improvements in implant design and materials, make it a viable option for younger patients seeking pain relief.
Individuals taking a class of steroid hormones called glucocorticoids for conditions such as asthma, allergies and arthritis on a routine basis may be unable to mount a normal stress response and are at high risk if they are infected with the virus causing COVID-19, according to a new editorial published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
No cure for osteoarthritis exists, but many treatments can help people manage the pain and stiffness that often occur.
Scientists at Fred Hutchinson Cancer Research Center identified a tiny protein in scorpion venom that rapidly accumulates in joint cartilage. Then they linked these mini-proteins with steroids to reverse inflammation in rats with arthritis. The researchers found that the drugs concentrated in the joints, potentially avoiding the body-wide toxicities and infection risks caused by nontargeted steroid treatment.
About 29 million Americans use over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) to treat pain. Every year in the U.S., NSAID use is attributed to approximately 100,000 hospitalizations and 17,000 deaths. All of these drugs have benefits and risks, but deciding which one to use is complicated for health care providers and their patients. To assist in clinical decision-making, researchers address cardiovascular risks and beyond, which include gastrointestinal and kidney side effects of pain relievers.
Secretary Clinton’s fractured elbow. Sonia Sotomayer’s broken ankle. Jane Fonda’s knee replacement. If you need an expert to discuss any of these timely topics, the American Academy of Orthopaedic Surgeons (AAOS) can provide expert sources to comment on musculoskeletal injury prevention, diagnosis and treatment.
The American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) released the 2019 ACR/EULAR Classification Criteria for IgG4-Related Disease. It is the first criteria developed specifically for this recently recognized disease.
A new study finds that children with Down syndrome are at an increased risk of an associated form of arthritis.
The Center for Medicinal Cannabis Research at University of California San Diego School of Medicine announces $3 million in research grants to explore new applications of cannabis for a number of novel medical applications.
Osteoarthritis can produce joint pain and stiffness sufficient to limit and even prohibit the performance of everyday tasks. It becomes more common with age, once it starts it typically gets worse and there’s no known cure. But there are therapies that can relieve pain and maintain joint function.
Contrary to popular belief, cartilage in human joints can repair itself through a process similar to that used by creatures such as salamanders and zebrafish to regenerate limbs, researchers at Duke Health found.
More than 50 million U.S. adults have arthritis. Many experience severe joint pain and, likely because of their pain, don’t do much exercising if at all. But medical experts say that while joint pain is often managed with medication, regular…