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UrduMore than 82% of Americans age 50 to 80 take one or more kinds of prescription medication, and 80% of them say they’d be open to stopping one or more of those drugs — with major differences among people with different health conditions.
Tag: Arthritis
Case Western Reserve University awarded federal contract to develop and commercialize ‘live’ replacement joints
A research team led by Case Western Reserve University will begin work on engineering, growing and commercializing “live” replacement joints to treat degenerative joint disease knowns as osteoarthritis (OA).
Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a
BACKGROUNDKnee osteoarthritis (KOA) is a common orthopedic condition with an uncertain etiology, possibly involving genetics and biomechanics. Factors like changes in chondrocyte microenvironment, oxidative stress, inflammation, and immune
High quality repair of osteochondral defects in rats using the extracellular matrix of antler stem cells
BACKGROUNDCartilage defects are some of the most common causes of arthritis. Cartilage lesions caused by inflammation, trauma or degenerative disease normally result in osteochondral defects. Previous studies have shown that decellularized
Interdisciplinary group creating biolubricants to combat arthritis
An interdisciplinary research team received a five-year, $2 million grant from the National Science Foundation to develop a new generation of biosynthetic lubricants that have the potential to treat arthritis and reduce the painful friction of artificial joints.
New Look at an Ancient Disease: Study Finds Novel Treatment Targets for Gout
UC San Diego scientists identify a new molecular model and potential therapeutic target for gout, the most common form of inflammatory arthritis.
Do Former Football Players Age Faster?
New research suggests that former professional football players may face accelerated aging, despite past research showing they have life spans similar or longer than the general population
In the new study, retired football players reported shorter health spans — defined as years free of disease – than men in the general population
Two age-related diseases — arthritis and dementia — were found more commonly among former football players, compared with men of the same age in the general population
Additionally, hypertension and diabetes were more common among younger former players, those ages 25 to 29, compared with same-age men from the general population.
The results warrant further study to define the biochemical, cellular, and physiologic mechanisms behind premature aging in former football players
Novel Study Identifies Key Molecular Players in Rheumatoid Arthritis
Using a novel systems biology approach, scientists at UC San Diego School of Medicine have further parsed the cellular players and roles involved in rheumatoid arthritis, a complex disease that affects more than one million Americans in ways that have defied development of uniform treatments.
Poll: Aching joints make older adults reach for many forms of pain relief – but health risks could follow
Popping a pill may bring short-term relief for arthritis-related joint pain, but many older adults may not realize that what they swallow could raise their risk of other health problems, or that other non-drug options could help them, a new poll suggests.
Flare-ups of gout are linked to heart attack and stroke, says new study
Experts at the University of Nottingham, in collaboration with experts at Keele University, have found that the risk of heart attacks and strokes temporarily increases in the four months after a gout flare.
Researchers Identify Potential Target for Treating Autoimmune Diseases
New research using a mouse model for multiple sclerosis has uncovered a potential new area to explore for possible treatments for autoimmune disorders.
Study: Obesity raises the risk of gum disease by inflating growth of bone-destroying cells
Chronic inflammation caused by obesity may trigger the development of cells that break down bone tissue, including the bone that holds teeth in place, according to new University at Buffalo research that sought to improve understanding of the connection between obesity and gum disease.
Study Finds Racial Gaps in Renal Complications Persist for Children with Lupus
New research presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, found that while hospitalized children with juvenile lupus have fewer adverse kidney outcomes overall, significant racial gaps for developing these complications persist and do not seem to be narrowing (Abstract #0956).
The Osteoarthritis Action Alliance Expands the Number of “Arthritis-Appropriate Evidence-Based Interventions” (AAEBIs) recognized by the Centers for Disease Control and Prevention from 7 to 18
The Osteoarthritis Action Alliance (OAAA) recently evaluated numerous evidence-based (medically proven) interventions to identify which met established criteria for being known as “Arthritis-Appropriate Evidence-Based Interventions” (AAEBIs). Programs that meet these criteria must be shown to improve arthritis symptoms, such as pain or limitations in function, and demonstrate that they have a sufficient level of support for program oversight and organized, wide-scale community delivery.
Discovery of a potential new therapy for inflammatory arthritis
Ankylosing spondylitis is a painful and inflammatory form of axial spondyloarthritis (SpA) which affects 1-2% of Canadians and causes inflammation in the spine, joints, eyes, gut and skin. In a new paper recently published in the journal Science Translational Medicine, researchers at the Schroeder Arthritis Institute at UHN have made a discovery that could lead to new treatments for SpA.
Rheumatoid arthritis treated with implanted cells that release drug
Researchers at Washington University School of Medicine in St. Louis have genetically engineered cells that, when implanted in mice, deliver a biologic drug in response to inflammation.
Researchers ID Sodium-dependent Cartilage Repair Response to Improve Osteoarthritis
Research published ahead of print in the journal Function finds sodium prompts the release of regenerative factors in articular cartilage that has sustained injury due to osteoarthritis. Osteoarthritis causes a loss of the protein aggrecan that is an integral part…
Considering More Than One Joint Replacement to Relieve Arthritis Pain?
When Lorry Graham needed multiple joint replacement surgeries for severe arthritis pain, she turned to Dr. Geoffrey Westrich at Hospital for Special Surgery. Mrs. Graham, who jokingly refers to herself as a “bionic woman,” and Dr. Westrich explain what to expect and give advice for the best outcome.
Engineers build nanostructures that fight inflammation
Nanofiber-based treatments stimulate the body to mount its own biological attack on immune disorders.
Researchers discover potential new approach to treating psoriatic joint inflammation
An international team of researchers, led by UC Davis Health, developed a new therapeutic approach to treating psoriatic arthritis, a chronic inflammatory disease affecting the joints.
Common Bacteria Modified To Make Designer Sugar-Based Drug
Envisioning an animal-free drug supply, scientists have — for the first time — reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals and nutraceuticals.
Repurposed Arthritis Drug Did Not Significantly Improve Severe COVID-19 Pneumonia
A repurposed drug used to treat arthritis did not significantly improve the outcomes of patients with severe COVID-19 pneumonia. Tocilizumab did not significantly improve clinical status or mortality rate at 28 days for participants who received it compared to a placebo.
STUDY PINS DOWN NUMBER OF AMERICANS WITH MOST COMMON FORM OF LUPUS
Just over 200,000 Americans suffer from systemic lupus erythematosus, or SLE, a condition in which the body’s immune system mistakenly attacks its own healthy tissues, especially joints and skin, a new study shows.
Pandemic Doesn’t Stop Dad from Hip Replacement So He Can Dance at Daughter’s Wedding
A Long Island dad wanted to dance with his daughter at her wedding, and he wasn’t going to let the pandemic or hip arthritis stop him. He had a hip replacement at Hospital for Special Surgery.
Investigators Discover Unique Immune Cells in Patients with Checkpoint Inhibitor-Induced Arthritis
A study from investigators at Hospital for Special Surgery (HSS) and Brigham and Women’s Hospital in Boston has found that the synovial fluid and blood of people experiencing checkpoint inhibitor-induced arthritis is populated by a type of T cells rarely seen in people with other types of inflammatory arthritis. The findings are being presented at the virtual American College of Rheumatology annual meeting.
Children with Arthritis Living in Less Affluent Families More Likely to Report Longer Duration of Morning Joint Stiffness
Children with arthritis affecting five or more joints, called polyarticular juvenile idiopathic arthritis (polyarticular JIA), living in less affluent families were twice as likely to report more than an hour of morning joint stiffness, compared to their counterparts from more affluent families, according to a study by investigators at Hospital for Special Surgery (HSS). Parents and physicians should be aware that morning joint stiffness may indicate early disease symptoms of polyarticular JIA and serve as a more reliable indicator than pain.
‘Incredibly generous’ $25 million donation to create the Schroeder Arthritis Institute at UHN, consolidating research, education and patient care under one global brand
One in five Canadian adults is currently living with arthritis, a disease causing inflammation of the joints, which can result in chronic, debilitating pain, reduced mobility and premature disability. Arthritis is the leading cause of disability globally. To address this growing crisis, the Schroeder Arthritis Institute, launched with a $25 million donation by philanthropists Walter and Maria Schroeder, will help UHN’s innovative arthritis program become a world-class hub for innovation in research, education and patient care.
Artificial Intelligence Detects Osteoarthritis Years Before it Develops
Researchers have created a machine-learning algorithm that can pick up on subtle signs of osteoarthritis – too abstract to register in the eye of a trained radiologist – on an MRI scan taken years before symptom onset.
Significantly less addictive opioid may slow progression of osteoarthritis while easing pain
A Keck Medicine of USC study reveals that kappa opioids, a significantly less addictive opioid, may preserve cartilage in joints and ease pain
Excess coffee consumption a culprit for poor health
Cappuccino, latte or short black, coffee is one of the most commonly consumed drinks in the world. But whether it’s good or bad for your health can be clarified by genetics, as a world-first study from the University of South Australia’s Australian Centre for Precision Health shows that excess coffee consumption can cause poor health.
Arthritis Drug Presents Promise as Treatment for COVID-19 Pneumonia
UC San Diego Health has launched a Phase III clinical trial to assess whether a medication used to treat rheumatoid might also have therapeutic value for patient with COVID-19 who have developed or are at high risk of developing serious lung damage from SARS-CoV-2 infections.
Not Too Young for Knee Replacement
Advances in knee replacement surgery, such as robotic-assisted surgery and improvements in implant design and materials, make it a viable option for younger patients seeking pain relief.
Individuals taking class of steroid medications at high risk for COVID-19
Individuals taking a class of steroid hormones called glucocorticoids for conditions such as asthma, allergies and arthritis on a routine basis may be unable to mount a normal stress response and are at high risk if they are infected with the virus causing COVID-19, according to a new editorial published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
The Medical Minute: Seven surprising facts about osteoarthritis
No cure for osteoarthritis exists, but many treatments can help people manage the pain and stiffness that often occur.
Tiny scorpion-derived proteins deliver arthritis drugs to joints in preclinical study
Scientists at Fred Hutchinson Cancer Research Center identified a tiny protein in scorpion venom that rapidly accumulates in joint cartilage. Then they linked these mini-proteins with steroids to reverse inflammation in rats with arthritis. The researchers found that the drugs concentrated in the joints, potentially avoiding the body-wide toxicities and infection risks caused by nontargeted steroid treatment.
Choosing Common Pain Relievers: It’s Complicated
About 29 million Americans use over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) to treat pain. Every year in the U.S., NSAID use is attributed to approximately 100,000 hospitalizations and 17,000 deaths. All of these drugs have benefits and risks, but deciding which one to use is complicated for health care providers and their patients. To assist in clinical decision-making, researchers address cardiovascular risks and beyond, which include gastrointestinal and kidney side effects of pain relievers.
Orthopaedic Surgeons Available to Comment on Musculoskeletal Healthcare News and Trends, Treatment Options, Fall Prevention and More
Secretary Clinton’s fractured elbow. Sonia Sotomayer’s broken ankle. Jane Fonda’s knee replacement. If you need an expert to discuss any of these timely topics, the American Academy of Orthopaedic Surgeons (AAOS) can provide expert sources to comment on musculoskeletal injury prevention, diagnosis and treatment.
ACR and EULAR Release New Classification Criteria for IgG4-Related Disease
The American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) released the 2019 ACR/EULAR Classification Criteria for IgG4-Related Disease. It is the first criteria developed specifically for this recently recognized disease.
Children with Down Syndrome at Increased Risk for Associated Inflammatory, Erosive Arthritis
A new study finds that children with Down syndrome are at an increased risk of an associated form of arthritis.
UC San Diego’s Center for Medicinal Cannabis Research Awards Grants for Five Novel Studies
The Center for Medicinal Cannabis Research at University of California San Diego School of Medicine announces $3 million in research grants to explore new applications of cannabis for a number of novel medical applications.
While there’s no cure for osteoarthritis, its symptoms can be managed
Osteoarthritis can produce joint pain and stiffness sufficient to limit and even prohibit the performance of everyday tasks. It becomes more common with age, once it starts it typically gets worse and there’s no known cure. But there are therapies that can relieve pain and maintain joint function.
Humans Have Salamander-Like Ability to Regrow Cartilage in Joints
Contrary to popular belief, cartilage in human joints can repair itself through a process similar to that used by creatures such as salamanders and zebrafish to regenerate limbs, researchers at Duke Health found.
Arthritis and exercise: Why it helps to be more physically active
More than 50 million U.S. adults have arthritis. Many experience severe joint pain and, likely because of their pain, don’t do much exercising if at all. But medical experts say that while joint pain is often managed with medication, regular…