Disadvantaged neighbourhoods and depression symptoms associated with premature aging

This study used two DNA methylation-based estimators, known as epigenetic clocks, to examine aging at the cellular level and estimate the difference between chronological age and biological age. Findings showed that neighbourhood deprivation and depressive symptoms were positively associated with acceleration of the epigenetic age estimated using the DNAm GrimAge clock.

Greater adversity in childhood linked to premature aging in midlife and beyond

The study analyzed data from 1,445 participants aged 45 to 85 years from the Canadian Longitudinal Study on Aging. The participants provided blood samples for DNA methylation analysis and completed a self-report questionnaire on ACEs. These experiences include childhood exposure to physical, emotional or sexual abuse, neglect, as well as exposure to parental intimate partner violence or poor parental mental health. The data was analyzed to determine if there was an association between early childhood adversity and accelerated biological aging.

Do Former Football Players Age Faster?

New research suggests that former professional football players may face accelerated aging, despite past research showing they have life spans similar or longer than the general population

In the new study, retired football players reported shorter health spans — defined as years free of disease – than men in the general population

Two age-related diseases — arthritis and dementia — were found more commonly among former football players, compared with men of the same age in the general population

Additionally, hypertension and diabetes were more common among younger former players, those ages 25 to 29, compared with same-age men from the general population.

The results warrant further study to define the biochemical, cellular, and physiologic mechanisms behind premature aging in former football players