Ovarian cancer is hard to diagnose in its early stages because it has vague symptoms, such as constipation, bloating, and back pain.
Many premature infants need mechanical ventilation to breathe. However, prolonged ventilation can lead to problems like respiratory diseases or ventilation-induced injury.Jonas Naumann and Mareike Zink study the physics of mechanical stress from ventilation at Leipzig University, in Leipzig, Germany and discovered some of the mechanisms that explain why premature lungs are especially sensitive to stress.
Researchers at University of Michigan developed a method to produce artificially grown miniature brains — called human brain organoids — free of animal cells that could greatly improve the way neurodegenerative conditions are studied and, eventually, treated. The work offers a solution to overcome Matrigel’s weaknesses.
Article title: Age-associated differences in the human lung extracellular matrix Authors: Maunick Lefin Koloko Ngassie, Maaike de Vries, Theo Borghuis, Wim Timens, Don D. Sin, David Nickle, Philippe Joubert, Peter Horvatovich, György Marko-Varga, Jacob J. Teske, Judith M. Vonk, Reinoud…
New research using a mouse model for multiple sclerosis has uncovered a potential new area to explore for possible treatments for autoimmune disorders.
Article title: PDIA3/ERp57 promotes a matrix-rich secretome that stimulates fibroblast adhesion through CCN2 Authors: Andrew L. Hellewell, Kate J. Heesom, Mark A. Jepson, Josephine C. Adams From the authors: “Thus, manipulation of PDIA3 or other relevant resident proteins within the…
A new study finds that manipulating the stiffness of the collagen-based support structure of airway cells could lead to a new treatment for asthma. The study is published ahead of print in the Journal of Applied Physiology. It was chosen as an APSselect article for June.
Researchers at the University of California, San Francisco, have discovered that aggressive, triple-negative breast cancers (TNBCs) can evade treatment by reorganizing and softening the collagen matrix that surrounds the cancer cells. The study, which will be published April 2 in the Journal of Experimental Medicine (JEM), shows that the softer matrix activates a signaling pathway that promotes the cancer cells’ survival, and suggests that targeting this pathway could enhance the effectiveness of chemo- and radiotherapy in TNBC patients.
Toxicological Sciences features leading research biotransformation, toxicokinetics, and pharmacokinetics; computational toxicology and databases; mixtures toxicology; and more in the October 2020 issue.