Wake Forest Institute for Regenerative Medicine (WFIRM) researchers are using a tumor organoid system to examine the effects of metabolites secreted by bacteria on a specialized immunotherapy – immune checkpoint blockage, a promising cancer treatment development – to determine why some patients don’t respond or develop a resistance to the treatment over time.
Using brain organoids, UC San Diego researchers discover mutational commonalities between muscular dystrophy type 1 and Rett syndrome, suggesting the potential of a similar treatment for both.
UC San Diego scientists use lab-grown human brain tissue to identify neural abnormalities in Pitt-Hopkins Syndrome and show gene therapy tools can rescue neural structure and function.
Researchers from the group of Hans Clevers in collaboration with the group of Bart Haagmans (Erasmus MC) established an organoid biobank to search for the genes that are essential for the spreading of a SARS-CoV2 infection.
Stem cell models derived from people with specific genomic variation recapitulate aspects of their autism spectrum disorder, providing a valuable model to study the condition and look for therapeutic interventions.
Frontotemporal dementias are a group of fatal and debilitating brain disorders for which there are no cures. In an article published July 26 in Cell, Mount Sinai researchers describe how they were able to recreate much of the damage seen in a widely studied form of the disease by growing special types of cerebral organoids in petri dishes.
NEWS STORIES IN THIS ISSUE:
– Study Says Failure to Rid Amyloid Beta Protein from Brain May Lead to Alzheimer’s Disease
– Johns Hopkins Medicine Team Discovers Novel Mediator of Once Mysterious Chronic Itch – Study Suggests Molecular Changes in Tissue Microenvironment May Promote Colorectal Cancer
– Researchers ID Anti-Inflammatory Proteins as Therapy Targets for Nasal and Sinus Problem
– Johns Hopkins Children’s Center Receives NIH Award to Study Dangerous Pediatric Disease
Animal models don’t consistently recapitulate human CDKL5 deficiency disorder (CDD), a rare form of epilepsy. Using personalized brain organoids — “mini-brains” in a lab dish derived from stem cells of patients deficient in CDKL5 protein — researchers at UC San…
How do different parts of the body communicate? Scientists at St. Jude are studying how signals sent from skeletal muscle affect the brain.
UC San Diego School of Medicine researchers are using stem cell-derived organoids to study how SARS-CoV-2 interacts with various organ systems. Their findings may help explain the wide variety in COVID-19 symptoms and aid the search for therapies.
A new study from UCLA and Stanford University researchers finds that three-dimensional human stem cell-derived ‘mini brain’ organoids can mature in a manner that is strikingly similar to human brain development.
Researchers at Washington University School of Medicine in St. Louis have found that patients with Barrett’s esophagus may be vulnerable to coronavirus infection from what they swallow.
UC San Diego researchers used brain organoids to identify two drug candidates that counteract the genetic deficiencies that cause Rett syndrome, a rare form of autism spectrum disorder.
Researchers at the University of Pittsburgh School of Medicine have combined synthetic biology with a machine learning algorithm to create human liver organoids with blood and bile handling systems. When implanted into mice with failing livers, the lab-grown replacement livers extended life.
Rutgers Cancer Institute investigator shares about a new project in which 4-dimensional (4D) printing of arrays that transform from cell-culture inserts into histological cassettes are utilized and hold patient tissue samples for rapid programmable drug testing to accelerate treatment testing for glioblastoma multiforme (GBM), a common brain tumor.
UC San Diego researchers use 3D human gut organoids to reveal the molecular system that keeps intestinal linings sealed, demonstrate how the system breaks down and how it can be strengthened with the diabetes drug metformin.
Glioblastomas are the most aggressive form of brain cancer – they grow and spread rapidly through the brain and are virtually impossible to eradicate, typically leading to death within one or two years of diagnosis. Scientists are constantly seeking more powerful targeted therapies, but so far without success — in part because glioblastomas are challenging to study in a laboratory setting.
Human Organoids: A New Dimension in Cell Biology Human organoids are being hailed as a major development in biomedicine in a recently-released report by the American Society for Cell Biology (ASCB). According to the report, human organoids “have the potential…