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28 Apr, 2024

Brain Organoids Help Illuminate and Test Treatments for Rare Form of Epilepsy

April 22, 2021 sarah JonasResearch Alert

Animal models don’t consistently recapitulate human CDKL5 deficiency disorder (CDD), a rare form of epilepsy. Using personalized brain organoids — “mini-brains” in a lab dish derived from stem cells of patients deficient in CDKL5 protein — researchers at UC San…

Kawate lab unveils structure of major membrane protein

April 20, 2020 sarah JonasResearch Results

In a paper published on Feb 12 in the journal eLife, Dr. Toshimitsu Kawate, associate professor in the Department of Molecular Medicine and his team reveal the form of pannexin1, a cellular membrane protein present in all vertebrates. With the size, shape and formation of this protein revealed for the first time, scientists can get closer to fine tuning new therapies for a multitude of diseases, including chronic pain, infertility and cancer.