SLAC/Stanford researchers discover how a nano-chamber in the cell directs protein folding

A landmark study by researchers at the Department of Energy’s SLAC National Accelerator Laboratory and Stanford University reveals how a tiny cellular machine called TRiC directs the folding of tubulin, a human protein that is the building block of microtubules that serve as the cell’s scaffolding and transport system.

SLAC, Stanford to host national service center for cryo-ET sample preparation

The NIH is establishing a national service center at the SLAC and Stanford where biomedical researchers can learn how to prepare extremely thin specimens that are frozen into a glassy state for cryogenic electron tomography (cryo-ET), a powerful tool for directly visualizing cellular components in 3D.

Near-atomic ‘maps’ reveal structure for maintaining pH balance in cells

GRAND RAPIDS, Mich. (Nov. 4, 2020) — For the first time, scientists have visualized a new class of molecular gates that maintain pH balance within brain cells, a critical function that keeps cells alive and helps prevent stroke and other brain injuries.

Kawate lab unveils structure of major membrane protein

In a paper published on Feb 12 in the journal eLife, Dr. Toshimitsu Kawate, associate professor in the Department of Molecular Medicine and his team reveal the form of pannexin1, a cellular membrane protein present in all vertebrates. With the size, shape and formation of this protein revealed for the first time, scientists can get closer to fine tuning new therapies for a multitude of diseases, including chronic pain, infertility and cancer.

Li et al., Matter, 26 June 2019

First Snapshots of Trapped CO2 Molecules Shed New Light on Carbon Capture

A new twist on cryo-EM imaging reveals what’s going on inside MOFs, highly porous nanoparticles with big potential for storing fuel, separating gases and removing carbon dioxide from the atmosphere. Menlo Park, Calif. — Scientists from the Department of Energy’s…