St. Jude researchers shed light on a key player in cancer development by exploring the ability of fusion oncoproteins to form condensates in cells.
Protein complexes that play a critical role in launching an immune response assemble in droplets that form within the liquid environment in cells much like oil droplets in water, UT Southwestern scientists report in a new study. The findings, published in Molecular Cell, could lead to new interventions to regulate immunity in individuals with overactive or underactive immune responses.
To investigate what happens inside cells when they are at risk of becoming cancerous, scientists at St. Jude Children’s Research Hospital have been using neutron scattering at Oak Ridge National Laboratory. The team is searching to better understand the altered state of the nucleolus—a membrane-less organelle inside the cell—when the cell is compromised. Novel insights into cell behavior at the atomic and molecular scales will enable better detection and treatment of cancer in its many forms.