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Why We Fit A Mini Brain with a Mini Cap

August 17, 2022 sarah JonasResearch Results

It could be the world’s tiniest EEG electrode cap, created to measure activity in a brain model the size of a pen dot. Its designers expect the device to lead to better understanding of neural disorders and how potentially dangerous chemicals affect the brain.

This engineering feat, led by Johns Hopkins University researchers and detailed today in Science Advances, expands what researchers can accomplish with organoids, including mini brains—the lab-grown balls of human cells that mimic some of a brain’s structure and functionality.

WFIRM researchers create specific cancer organoid system to study bacterial effects on immunotherapy

July 29, 2022 sarah JonasResearch Results

Wake Forest Institute for Regenerative Medicine (WFIRM) researchers are using a tumor organoid system to examine the effects of metabolites secreted by bacteria on a specialized immunotherapy – immune checkpoint blockage, a promising cancer treatment development – to determine why some patients don’t respond or develop a resistance to the treatment over time.

Personalized Immunotherapy Response Studied in Body-on-a-Chip Cancer Models

July 19, 2021 sarah JonasResearch Results

Wake Forest researchers and clinicians are using patient-specific tumor ‘organoid’ models as a preclinical companion platform to better evaluate immunotherapy treatment for appendiceal cancer.

‘Mini brain’ organoids grown in lab mature much like infant brains

February 22, 2021 sarah JonasResearch Results

A new study from UCLA and Stanford University researchers finds that three-dimensional human stem cell-derived ‘mini brain’ organoids can mature in a manner that is strikingly similar to human brain development.