Protein nanoparticle vaccine shows potential for broader, safe SARS-CoV-2 vaccines, biomedical sciences researchers find

A nanoparticle vaccine that combines two proteins that induce immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that has caused the global pandemic, has the potential to be developed into broader and safe SARS-CoV-2 vaccines, according to researchers in the Institute for Biomedical Sciences at Georgia State University.

Study shows that vaccinated individuals develop more robust and broadly reactive antibody responses against SARS-CoV-2 variants than the unvaccinated after an Omicron infection

A recent study jointly conducted by the LKS Faculty of Medicine, The University of Hong Kong (HKUMed) and the Faculty of Medicine, The Chinese University of Hong Kong (CU Medicine) shows that vaccinated individuals can develop more robust and broadly reactive antibody responses against SARS-CoV-2 variants than unvaccinated individuals after an Omicron infection.

Comparing SARS-CoV-2 antibody response after Moderna, Pfizer-BioNTech vaccines in immunosuppressed patients

About The Study: Researchers compared antispike antibody titers after the 2-dose Pfizer-BioNTech and Moderna COVID-19 vaccines in incrementally immunosuppressed patients. These individuals, such as people with rheumatic and musculoskeletal diseases and solid organ transplant recipients, have decreased immune responses to these…

COVID-19, MIS-C and Kawasaki Disease Share Same Immune Response

COVID-19, MIS-C and KD all share a similar underlying mechanism involving the over-activation of particular inflammatory pathways, UC San Diego study shows. Findings support novel drug targets for MIS-C.

Texas Biomed and partners discover new, potent COVID-19 antibody cocktail

Researchers at Texas Biomed and University of Alabama at Birmingham discovered an antibody cocktail against COVID-19 that appears effective against all variants and other coronaviruses. The cocktail has been exclusively licensed to Aridis Pharmaceuticals, which is seeking a manufacturing partner to advance the treatment to human clinical trials.

Yale researchers develop RNA-based therapy that clears SARS-CoV-2 from mice

Researchers at Yale School of Medicine have discovered that an RNA molecule that stimulates the body’s early antiviral defense system can protect mice from a range of emerging SARS-CoV-2 variants. The study, published today in the Journal of Experimental Medicine (JEM), could lead to new treatments for COVID-19 in immunocompromised patients, as well as providing an inexpensive therapeutic option for developing countries that currently lack access to vaccines.

Genome sequencing reveals widespread COVID-19 infection in white-tailed deer

Houston Methodist’s SARS-CoV-2 genome sequencing team has partnered on a study led by Penn State that revealed 80% of white-tailed deer sampled across Iowa at the height of the 2020-2021 deer-hunting season tested positive for the SARS-CoV-2 virus. Analysis of the virus genome sequences revealed infections were likely the result of multiple human-to-deer transmission “spillover” events followed by deer-to-deer transmission from April 2020 through January 2021.

Statins Likely Not Helpful In Reducing Covid-19 Mortality or Severity

Findings from a recent Johns Hopkins Medicine-led study of nearly 4,500 patients hospitalized with COVID-19 over a four-month period provide a stronger case for a very different conclusion: Statins likely did not confer any impact — positive or negative — on COVID-related mortality and may be associated with an significantly increased risk — nearly 1 chance in 5 — of more serious illness.

Previously Healthy Young Adults with ‘Long COVID’ Show Vascular Dysfunction in Limbs, but Not Brain

A first-of-its-kind study of young adults with positive COVID-19 tests from more than 4 weeks ago found that those who were still symptomatic (i.e., long-haulers) had impaired blood vessel function in their limbs, but not brains. Asymptotic participants had blood vessel function similar to controls.

Study: No Serious COVID-19 Vaccine Side Effects in Breastfeeding Moms, Infants

Researchers found that breastfeeding mothers who received either the Pfizer-BioNTech or Moderna vaccination reported the same local or systemic symptoms as what has been previously reported in non-breastfeeding women, with no serious side effects in the breastfed infants.

Second Breath: Region’s First Double Lung Transplant for COVID-19 Patient

After more than 50 days on advanced life support, a multi-disciplinary team at UC San Diego Health helps a patient who contracted COVID-19 become a candidate for a successful double lung transplant. The transplant surgery was the first in the region performed on a COVID-19 patient.

In transplant recipients, COVID-19 vaccines reduce infection and mortality risks

Vaccination against SARS-CoV-2 substantially lowers the risks of “breakthrough” infections and death due to COVID-19 in adult organ transplant recipients, according to a pair of research letters in Transplantation, the official Journal of The Transplantation Society and the International Liver Transplantation Society. The journal is published in the Lippincott portfolio by Wolters Kluwer.

Hopkins Med News Update

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– COVID-19 NEWS: Johns Hopkins Medicine Study Shows Vaccine Likely Protects People with HIV
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Vaccine Hesitancy and Pregnancy: @UCSDHealth expert on why you should get the COVID-19 shot

With recent statewide vaccination mandates, members of the public may have questions or concerns about the safety and effectiveness of COVID-19 vaccination, especially in pregnant mothers. Cynthia Gyamfi-Bannerman, MD, professor and chair of Obstetrics, Gynecology and Reproductive Sciences at UC…

Study shows neutralizing antibodies to SARS-CoV-2 remain relatively high for up to 13 months following infection

  New York, NY – Researchers from the Icahn School of Medicine at Mount Sinai have found that most COVID-19 patients have persistent antibodies to the SARS-CoV-2 virus at levels that are correlated with neutralization of the virus more than…

Antibodies to SARS-CoV-2 Remain Stable, or Even Increase, Seven Months After Infection

The levels of IgG antibodies against SARS-CoV-2 Spike protein remain stable, or even increase, seven months after infection, according to a follow-up study in a cohort of healthcare workers coordinated by the Barcelona Institute for Global Health (ISGlobal), an institution supported by “la Caixa” Foundation, in collaboration with the Hospital Clinic of Barcelona.

UAH’s Baudry Lab part of half-million-dollar efforts to target COVID with drug therapies

Two different strategies to discover and perfect pharmaceuticals active against the COVID-19 virus have attracted a half million dollars in research funding to support five institutions, including the Baudry Lab at The University of Alabama in Huntsville (UAH).

利用人工智能筛选3000万种针对SARS-CoV-2的候选药物

妙佑医疗国际(Mayo Clinic)的研究人员和合作者利用计算机模拟和人工智能(AI)来筛选3000万种候选药物,这些药物有可能阻断导致COVID-19的SARS-CoV-2病毒。在一篇发表在《Biomolecules》上的论文中,研究人员阐述了他们如何加速药物发现,从而为开展进一步的研究确定最有希望的目标。他们的最终目的是寻找治疗COVID-19的新方法。

What if We Could Give Viruses a One-Two Punch?

Researchers at Stanford and Berkeley Lab’s Molecular Foundry have developed virus-killing molecules called peptoids. The technology could make possible an emerging category of antiviral drugs that could treat everything from herpes and COVID-19 to the common cold.

Scientists repurpose cancer and seizure medications to aid in the fight against COVID-19

Two teams of researchers using the Advanced Photon Source identified existing drugs — one used to treat cancer, the other an anti-seizure medication — that may work as treatments for COVID-19.

Imaging Test May Predict Patients Most at Risk of Some Heart Complications from COVID-19

Researchers at Johns Hopkins Medicine have shown that a type of echocardiogram, a common test to evaluate whether a person’s heart is pumping properly, may be useful in predicting which patients with COVID-19 are most at risk of developing atrial fibrillation — an irregular heartbeat that can increase a person’s risk for heart failure and stroke, among other heart issues. The new findings, published online May 30 in the Journal of the American Society of Echocardiography, also suggest that patients with COVID-19 who go on to develop atrial fibrillation more commonly have elevated levels of heart-related proteins called troponin and NT-proBNP in blood test samples.

Cutting out the proteins that give SARS-CoV-2 its power

Researchers at Texas Biomedical Research Institute (Texas Biomed) have narrowed down the proteins enabling SARS-CoV-2 to cause disease. Using advanced genetic engineering techniques developed at Texas Biomed, they systematically deleted the genetic code for five of the virus’s accessory proteins, one at a time, to see how each one affected the virus’s ability to spread and cause illness. The research was published online this month in the Journal of Virology.

UC San Diego Health Adopts SMART Health Card for Digital Vaccine Records

UC San Diego Health is now offering a verifiable digital vaccine record to its patients who have or will receive a COVID-19 vaccine. These secure online records, otherwise known as a SMART health card, can be accessed directly from the MyUCSDChart patient portal.