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UrduThe University of Kent’s School of Biosciences and the Institute of Medical Virology at Goethe-University, Frankfurt am Main, have identified a protein that may critically contribute to severe forms of COVID-19.
Tag: SARS-CoV-2
Inhibiting targets of SARS-CoV-2 proteases can block infection, study shows
Researchers at the University of Liverpool have shown how SARS-CoV-2 viral proteases attack the host cell, and how this can be targeted to stop virus replication in cell culture using existing drugs.
Previously Healthy Young Adults with ‘Long COVID’ Show Vascular Dysfunction in Limbs, but Not Brain
A first-of-its-kind study of young adults with positive COVID-19 tests from more than 4 weeks ago found that those who were still symptomatic (i.e., long-haulers) had impaired blood vessel function in their limbs, but not brains. Asymptotic participants had blood vessel function similar to controls.
Infection detection: DNA researchers develop critical shortcut to detect and identify known and emerging pathogens
Researchers at McMaster University have developed a sophisticated new tool that could help provide early warning of rare and unknown viruses in the environment and identify potentially deadly bacterial pathogens which cause sepsis, among other uses.
3D analysis of SARS-CoV-2 reveals clues on virus tactics
The most comprehensive analysis of the 3D structure of SARS-CoV-2 to date has revealed new insight on how the virus infects human cells and replicates.
UAMS Research Team Finds Potential Cause of COVID-19 ‘Long-haulers’
A research team has identified a potential cause of long-lasting symptoms experienced by COVID-19 patients, often referred to as long-haulers. The findings were published in the journal, The Public Library of Science ONE (PLOS ONE).
OFF-TARGET IMMUNE RESPONSE COULD PREDICT COVID-19 SEVERITY
The presence of special immune system defense molecules, called autoimmune antibodies, has been strongly tied to how poorly people fare when hospitalized with COVID-19, a new study shows.
Study: No Serious COVID-19 Vaccine Side Effects in Breastfeeding Moms, Infants
Researchers found that breastfeeding mothers who received either the Pfizer-BioNTech or Moderna vaccination reported the same local or systemic symptoms as what has been previously reported in non-breastfeeding women, with no serious side effects in the breastfed infants.
Argonne collaborations bring computational tools to the forefront of COVID-19 research
Argonne, industry and academia collaborate to bring innovative AI and simulation tools to the COVID-19 battlefront.
Hopkins Med News Update
News stories in this issue
Second Breath: Region’s First Double Lung Transplant for COVID-19 Patient
After more than 50 days on advanced life support, a multi-disciplinary team at UC San Diego Health helps a patient who contracted COVID-19 become a candidate for a successful double lung transplant. The transplant surgery was the first in the region performed on a COVID-19 patient.
Antibody protects against broad range of COVID-19 virus variants
Researchers at Washington University School of Medicine in St. Louis have identified an antibody that is highly protective against a broad range of viral variants.
In transplant recipients, COVID-19 vaccines reduce infection and mortality risks
Vaccination against SARS-CoV-2 substantially lowers the risks of “breakthrough” infections and death due to COVID-19 in adult organ transplant recipients, according to a pair of research letters in Transplantation, the official Journal of The Transplantation Society and the International Liver Transplantation Society. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Hopkins Med News Update
NEWS STORIES IN THIS ISSUE:
– COVID-19 NEWS: Johns Hopkins Medicine Study Shows Vaccine Likely Protects People with HIV
– Johns Hopkins Medicine Documents Stroke Risk in Cardiac Assist Device
– CBD Products May Help People with Epilepsy Better Tolerate Anti-Seizure Medications
Most of UC San Diego’s COVID-19 Cases Detected Early by Wastewater Screening
Part of UC San Diego’s Return to Learn program, wastewater screening helped prevent outbreaks by detecting 85 percent of cases early, allowing for timely testing, contact tracing and isolation.
Vaccine Hesitancy and Pregnancy: @UCSDHealth expert on why you should get the COVID-19 shot
With recent statewide vaccination mandates, members of the public may have questions or concerns about the safety and effectiveness of COVID-19 vaccination, especially in pregnant mothers. Cynthia Gyamfi-Bannerman, MD, professor and chair of Obstetrics, Gynecology and Reproductive Sciences at UC…
Licensed Drug Could Reduce SARS-CoV-2 Infection by Up to 70 Per Cent, Reveals Study
A licensed drug normally used to treat abnormal levels of fatty substances in the blood could reduce infection caused by the SARS-CoV-2 virus by up to 70 per cent, reveals a study in the laboratory by an international collaboration of researchers.
Study shows neutralizing antibodies to SARS-CoV-2 remain relatively high for up to 13 months following infection
New York, NY – Researchers from the Icahn School of Medicine at Mount Sinai have found that most COVID-19 patients have persistent antibodies to the SARS-CoV-2 virus at levels that are correlated with neutralization of the virus more than…
Antibodies to SARS-CoV-2 Remain Stable, or Even Increase, Seven Months After Infection
The levels of IgG antibodies against SARS-CoV-2 Spike protein remain stable, or even increase, seven months after infection, according to a follow-up study in a cohort of healthcare workers coordinated by the Barcelona Institute for Global Health (ISGlobal), an institution supported by “la Caixa” Foundation, in collaboration with the Hospital Clinic of Barcelona.
Rethinking Remdesivir
UC San Diego researchers modify remdesivir, creating oral version that can be taken earlier in COVID-19 diagnoses. In cell and animal studies, revised drug proved effective and safe.
No Particular Risk of Infection of SARS-CoV-2 From Cash
How long do coronaviruses remain infectious on banknotes and coins? Is it possible to become infected through contact with cash?
UAH’s Baudry Lab part of half-million-dollar efforts to target COVID with drug therapies
Two different strategies to discover and perfect pharmaceuticals active against the COVID-19 virus have attracted a half million dollars in research funding to support five institutions, including the Baudry Lab at The University of Alabama in Huntsville (UAH).
Highly Potent, Stable Nanobodies Stop SARS-CoV-2
Göttingen researchers have developed mini-antibodies that efficiently block the coronavirus SARS-CoV-2 and its dangerous new variants.
利用人工智能筛选3000万种针对SARS-CoV-2的候选药物
妙佑医疗国际(Mayo Clinic)的研究人员和合作者利用计算机模拟和人工智能(AI)来筛选3000万种候选药物，这些药物有可能阻断导致COVID-19的SARS-CoV-2病毒。在一篇发表在《Biomolecules》上的论文中，研究人员阐述了他们如何加速药物发现，从而为开展进一步的研究确定最有希望的目标。他们的最终目的是寻找治疗COVID-19的新方法。
What if We Could Give Viruses a One-Two Punch?
Researchers at Stanford and Berkeley Lab’s Molecular Foundry have developed virus-killing molecules called peptoids. The technology could make possible an emerging category of antiviral drugs that could treat everything from herpes and COVID-19 to the common cold.
A rapid method to quantify antibodies against SARS-CoV-2
Scientists have developed a rapid, highly accurate test to detect antibodies against the spike protein of SARS-CoV-2 in human serum, opening a new avenue for understanding the full extent of the pandemic and evaluating the effectiveness of vaccines.
Scientists repurpose cancer and seizure medications to aid in the fight against COVID-19
Two teams of researchers using the Advanced Photon Source identified existing drugs — one used to treat cancer, the other an anti-seizure medication — that may work as treatments for COVID-19.
Usando a inteligência artificial para fazer a triagem de 30 milhões de possíveis medicamentos contra o SARS-CoV-2
Os pesquisadores e colaboradores da Mayo Clinic usaram a simulação em computadores e inteligência artificial (AI) para fazer a triagem virtual de 30 milhões de possíveis medicamentos que podem bloquear o SARS-CoV-2, o vírus que causa a COVID-19.
Imaging Test May Predict Patients Most at Risk of Some Heart Complications from COVID-19
Researchers at Johns Hopkins Medicine have shown that a type of echocardiogram, a common test to evaluate whether a person’s heart is pumping properly, may be useful in predicting which patients with COVID-19 are most at risk of developing atrial fibrillation — an irregular heartbeat that can increase a person’s risk for heart failure and stroke, among other heart issues. The new findings, published online May 30 in the Journal of the American Society of Echocardiography, also suggest that patients with COVID-19 who go on to develop atrial fibrillation more commonly have elevated levels of heart-related proteins called troponin and NT-proBNP in blood test samples.
Cutting out the proteins that give SARS-CoV-2 its power
Researchers at Texas Biomedical Research Institute (Texas Biomed) have narrowed down the proteins enabling SARS-CoV-2 to cause disease. Using advanced genetic engineering techniques developed at Texas Biomed, they systematically deleted the genetic code for five of the virus’s accessory proteins, one at a time, to see how each one affected the virus’s ability to spread and cause illness. The research was published online this month in the Journal of Virology.
UC San Diego Health Adopts SMART Health Card for Digital Vaccine Records
UC San Diego Health is now offering a verifiable digital vaccine record to its patients who have or will receive a COVID-19 vaccine. These secure online records, otherwise known as a SMART health card, can be accessed directly from the MyUCSDChart patient portal.
Study confirms the low likelihood that SARS-CoV-2 on hospital surfaces is infectious
A new study confirms the low likelihood that coronavirus contamination on hospital surfaces is infectious. The study is the original report on recovering near-complete SARS-CoV-2 genome sequences directly from surface swabs.
Virus that causes COVID-19 can find alternate route to infect cells
The virus that causes COVID-19 normally gets inside cells by attaching to a protein called ACE2. Researchers at Washington University School of Medicine in St. Louis have found that a single mutation confers the ability to enter cells through another route, which may threaten the effectiveness of COVID-19 vaccines and therapeutics designed to block the standard route of entry.
Had COVID-19? One vaccine dose enough; boosters for all, study says
A new study in ACS Nano supports increasing evidence that people who had COVID-19 need only one vaccine dose, and that boosters could be necessary for everyone in the future.
Engineering nanobodies as lifesavers when SARS-CoV-2 variants attack
Scientists are pursuing a new strategy in the protracted fight against the SARS-CoV-2 virus by engineering nanobodies that can neutralize virus variants in two different ways.
COVID-19 dual-antibody therapies effective against variants in animal study
A study from Washington University School of Medicine in St. Louis suggests that many, but not all, COVID-19 therapies made from combinations of two antibodies are effective against a wide range of virus variants, and that combination therapies appear to prevent the emergence of drug resistance.
Biophysical study sheds light on potentially druggable process of SARS-CoV-2 replication
This study investigates how the nucleocapsid protein, or N protein, of the SARS-CoV-2 virus packages the viral genome.
SARS-CoV-2 Worldwide Replication Drives Rapid Rise and Selection of Mutations
The number of COVID-19 variants is growing rapidly, so much that the scale and scope of mutation may pose a threat to the continuing successful use of the current vaccines and therapies. The findings, by an international team that includes University of California researchers, are being published in the June edition of the peer-reviewed journal EMBO Molecular Medicine. The pace of variation of the SARS-CoV-2 virus strains makes plain the threat that rapidly evolving new strains might give rise to escape variants, capable of limiting the efficacy of vaccines, therapies, and diagnostic tests.
Rapid exclusion of COVID-19 infection using AI, EKG technology
Artificial intelligence (AI) may offer a way to accurately determine that a person is not infected with COVID-19. An international retrospective study finds that infection with SARS-CoV-2, the virus that causes COVID-19, creates subtle electrical changes in the heart. An AI-enhanced EKG can detect these changes and potentially be used as a rapid, reliable COVID-19 screening test to rule out COVID-19 infection.
For Transplant Recipients, Third Time May Be the Charm for Better COVID Vaccine Protection
In a study published today in the Annals of Internal Medicine, Johns Hopkins Medicine researchers say they believe that, for the first time, there is evidence to show that three doses of vaccine increase antibody levels against SARS-CoV-2 — the virus that causes COVID 19 — more than the standard two-dose regimen for people who have received solid organ transplants.
AI Predicts How Patients with Viral Infections, Including COVID-19, Will Fare
UC San Diego School of Medicine researchers discovered gene expression patterns associated with pandemic viral infections, providing a map to help define patients’ immune responses, measure disease severity, predict outcomes and test therapies — for current and future pandemics.
SARS-CoV-2 Detectable — Though Likely Not Transmissible — on Hospital Surfaces
UC San Diego School of Medicine researchers discovered that SARS-CoV-2, or at least its genetic signature, abounds on hospital surfaces, often co-locating with one particular type of bacteria.
Story Tips from Johns Hopkins Experts on COVID-19
NEWS STORIES IN THIS ISSUE:
-Physician and Musician: Johns Hopkins Doctor Brings Passion for Music to Medicine During Pandemic
-Rapid, At-Home Blood Test Could Confirm COVID-19 Vaccination in Minutes
-What to Expect and Prepare for As You Return to Regular Health Care Appointments
-Study Suggests Sudden Hearing Loss Not Associated with COVID-19 Vaccination
-Vaccination May Not Rid COVID-19 Risk for Those with Rheumatic, Musculoskeletal Diseases
Cross Border Effort to Vaccinate 10,000 Maquiladora Workers
A coalition of six U.S. subsidiary companies have sponsored a COVID-19 mobile clinic to vaccinate 10,000 maquiladora workers employed in Baja California, Mexico. UC San Diego Health is vaccinating about 1,500 workers daily.
Will COVID-19 Eventually Become Just a Seasonal Nuisance?
Within the next decade, the novel coronavirus responsible for COVID-19 could become little more than a nuisance, causing no more than common cold-like coughs and sniffles. That possible future is predicted by mathematical models that incorporate lessons learned from the current pandemic on how our body’s immunity changes over time. Scientists at the University of Utah carried out the research, now published in the journal Viruses.
Comprehensive Mount Sinai Study Shows Direct Evidence That COVID-19 Can Infect Cells in Eye
Study Has Implications for Preventive Measures to Slow Spread of Virus
Dental procedures during pandemic are no riskier than a drink of water
A new study’s findings dispel the misconception that patients and providers are at high risk of catching COVID-19 at the dentist’s office.
With “herd immunity” unlikely, antivirals will play key role in COVID-19 management
According to The New York Times, the prospects for reaching “herd immunity” in the fight against COVID-19 are increasingly dim. Subsequently, the virus “will most likely become a manageable threat that will continue to circulate in the United States for…
Organ Transplant Recipients Remain Vulnerable to Covid-19 Even After Second Vaccine Dose
In a study published today in the Journal of the American Medical Association (JAMA), Johns Hopkins Medicine researchers show that although two doses of a vaccine against SARS-CoV-2 — the virus that causes COVID 19 — confers some protection for people who have received solid organ transplants, it’s still not enough to enable them to dispense with masks, physical distancing and other safety measures.
Rutgers Engineers Developing Rapid Breathalyzer Test for COVID-19
New Brunswick, N.J. (April 30, 2021) – Rutgers University–New Brunswick engineering professors Edward P. DeMauro, German Drazer, Hao Lin and Mehdi Javanmard are available for interviews on their work to develop a new type of fast-acting COVID-19 sensor that detects the presence…