Severe COVID-19 caused by “senile” interferon response in older patients, researchers suggest

Researchers in Germany have discovered that age-dependent impairments in antiviral interferon proteins underlie the increased susceptibility of older patients to severe COVID-19. The study, published today in the Journal of Experimental Medicine (JEM), shows that aged mice infected with SARS-CoV-2 are protected from severe disease by treatment with one of these interferons, IFN-γ.

SARS-CoV-2 protein caught severing critical immunity pathway

Over the past two years, scientists have studied the SARS-CoV-2 virus in great detail, laying the foundation for developing COVID-19 vaccines and antiviral treatments. Now, for the first time, scientists at the Department of Energy’s SLAC National Accelerator Laboratory have seen one of the virus’s most critical interactions, which could help researchers develop more precise treatments.

Hyperactivation of the Immune System May Cause Post-COVID Syndromes

Investigators at Cedars-Sinai have proposed a theory for how SARS-CoV-2, the virus that causes COVID-19, infects the body. Their hypothesis, published in Frontiers in Immunology, could explain why some people still have symptoms long after the initial infection.

Researchers ID Low Immune Cell Responsiveness and High Level of Proteins as Features of COVID-19 Severity

Article title: Chemokines, soluble PD-L1 and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness Authors: Eric D. Morrell, Pavan K. Bhatraju, Neha A. Sathe, Jonathan Lawson, Linzee Mabrey, Sarah E. Holton, Scott R. Presnell, Alice Wiedeman, Carolina Acosta-Vega,…

Novel Research Sheds Light on Antibody Responses to the SARS-CoV-2 Virus and Vaccines

Two studies presented today at the 2022 AACC Annual Scientific Meeting & Clinical Lab Expo reveal how SARS-CoV-2 antibody levels vary among recipients of COVID-19 vaccines and naturally infected individuals. These findings add to a growing body of knowledge that is essential for guiding public health initiatives, and that might one day enable clinicians to assess individuals’ immunity to SARS-CoV-2.

Immune Molecules From a Llama Could Provide Protection Against a Vast Array of SARS-like Viruses Including COVID-19, Researchers Say

Mount Sinai-led researchers have shown that tiny, robust immune particles derived from the blood of a llama could provide strong protection against every COVID-19 variant, including Omicron, and 18 similar viruses.

Mount Sinai Researchers Develop Machine Learning Model that Can Detect and Predict COVID-19 from Collected Data on Wearable Devices

Mount Sinai researchers have developed a machine learning algorithm that can determine if an individual has SARS-CoV-2 infections, the virus that causes COVID-19—with a high sensitivity and specificity—from the data collected by wearable devices.

Broadly neutralizing antibodies could provide immunity against SARS-CoV-2 variants

Two broadly neutralizing antibodies show great promise to provide long-acting immunity against COVID-19 in immunocompromised populations according to a paper published June 15 in the Journal of Experimental Medicine (JEM). The antibodies were effective against all SARS-CoV-2 variants of concern tested and could be used alone or in an antibody cocktail to diminish the risk of infection.

Mount Sinai Researchers Awarded $16 Million to Develop Antivirals Against Viruses With Pandemic Potential

Researchers at the Icahn School of Medicine at Mount Sinai have been awarded an initial $16 million from the National Institutes of Health (NIH) to discover and develop globally accessible and affordable novel oral antivirals to combat COVID-19 and future pandemics.

Protein nanoparticle vaccine shows potential for broader, safe SARS-CoV-2 vaccines, biomedical sciences researchers find

A nanoparticle vaccine that combines two proteins that induce immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that has caused the global pandemic, has the potential to be developed into broader and safe SARS-CoV-2 vaccines, according to researchers in the Institute for Biomedical Sciences at Georgia State University.

Study shows that vaccinated individuals develop more robust and broadly reactive antibody responses against SARS-CoV-2 variants than the unvaccinated after an Omicron infection

A recent study jointly conducted by the LKS Faculty of Medicine, The University of Hong Kong (HKUMed) and the Faculty of Medicine, The Chinese University of Hong Kong (CU Medicine) shows that vaccinated individuals can develop more robust and broadly reactive antibody responses against SARS-CoV-2 variants than unvaccinated individuals after an Omicron infection.

Comparing SARS-CoV-2 antibody response after Moderna, Pfizer-BioNTech vaccines in immunosuppressed patients

About The Study: Researchers compared antispike antibody titers after the 2-dose Pfizer-BioNTech and Moderna COVID-19 vaccines in incrementally immunosuppressed patients. These individuals, such as people with rheumatic and musculoskeletal diseases and solid organ transplant recipients, have decreased immune responses to these…

COVID-19, MIS-C and Kawasaki Disease Share Same Immune Response

COVID-19, MIS-C and KD all share a similar underlying mechanism involving the over-activation of particular inflammatory pathways, UC San Diego study shows. Findings support novel drug targets for MIS-C.

Texas Biomed and partners discover new, potent COVID-19 antibody cocktail

Researchers at Texas Biomed and University of Alabama at Birmingham discovered an antibody cocktail against COVID-19 that appears effective against all variants and other coronaviruses. The cocktail has been exclusively licensed to Aridis Pharmaceuticals, which is seeking a manufacturing partner to advance the treatment to human clinical trials.

Yale researchers develop RNA-based therapy that clears SARS-CoV-2 from mice

Researchers at Yale School of Medicine have discovered that an RNA molecule that stimulates the body’s early antiviral defense system can protect mice from a range of emerging SARS-CoV-2 variants. The study, published today in the Journal of Experimental Medicine (JEM), could lead to new treatments for COVID-19 in immunocompromised patients, as well as providing an inexpensive therapeutic option for developing countries that currently lack access to vaccines.

Genome sequencing reveals widespread COVID-19 infection in white-tailed deer

Houston Methodist’s SARS-CoV-2 genome sequencing team has partnered on a study led by Penn State that revealed 80% of white-tailed deer sampled across Iowa at the height of the 2020-2021 deer-hunting season tested positive for the SARS-CoV-2 virus. Analysis of the virus genome sequences revealed infections were likely the result of multiple human-to-deer transmission “spillover” events followed by deer-to-deer transmission from April 2020 through January 2021.

Statins Likely Not Helpful In Reducing Covid-19 Mortality or Severity

Findings from a recent Johns Hopkins Medicine-led study of nearly 4,500 patients hospitalized with COVID-19 over a four-month period provide a stronger case for a very different conclusion: Statins likely did not confer any impact — positive or negative — on COVID-related mortality and may be associated with an significantly increased risk — nearly 1 chance in 5 — of more serious illness.

Previously Healthy Young Adults with ‘Long COVID’ Show Vascular Dysfunction in Limbs, but Not Brain

A first-of-its-kind study of young adults with positive COVID-19 tests from more than 4 weeks ago found that those who were still symptomatic (i.e., long-haulers) had impaired blood vessel function in their limbs, but not brains. Asymptotic participants had blood vessel function similar to controls.

Study: No Serious COVID-19 Vaccine Side Effects in Breastfeeding Moms, Infants

Researchers found that breastfeeding mothers who received either the Pfizer-BioNTech or Moderna vaccination reported the same local or systemic symptoms as what has been previously reported in non-breastfeeding women, with no serious side effects in the breastfed infants.