Reduced Expression of Dual Oxidase 1 Enzyme May Contribute to Age-related Emphysema

Article title: Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema Authors: Caspar Schiffers, Lennart K.A. Lundblad, Milena Hristova, Aida Habibovic, Christopher M. Dustin, Nirav Daphtary, Minara Aliyeva, David J. Seward, Yvonne M.…

Mouse Study Suggests Androgens and Their Receptors Play Important and Positive Role in Asthma

Article title: Androgen receptor activation alleviates airway hyperresponsiveness, inflammation and remodeling in a murine model of asthma Authors: Rama Satyanarayana Raju Kalidhindi, Nilesh Sudhakar Ambhore, Premanand Balraj, Taylor Schmidt, M. Nadeem Khan, Venkatachalem Sathish From the authors: “Overall, our findings from…

Blocking Cell Death Protein Reduces COPD-associated Inflammation, Lung Damage

Article title: Blockade of PD-1 decreases neutrophilic inflammation and lung damage in experimental COPD Authors Felix Ritzmann, Kai Borchardt, Giovanna Vella, Praneeth Chitirala, Adrian Angenendt, Christian Herr, Michael D. Menger, Markus Hoth, Annette Lis, Rainer M Bohle, Robert Bals, Christoph…

Targeting mechanosensitive protein could treat pulmonary fibrosis, study suggests

Researchers at the University of Alabama at Birmingham have identified a new molecular target that could potentially treat the deadly, aging-related lung disease idiopathic pulmonary fibrosis (IPF). The study, which will be published March 10 in the Journal of Experimental Medicine (JEM), suggests that targeting a protein called MDM4 could prevent respiratory failure by initiating a genetic program that removes scar tissue from the lungs.

Immune cell implicated in development of lung disease following viral infection

Scientists at Washington University School of Medicine in St. Louis have implicated a type of immune cell in the development of chronic lung disease that sometimes is triggered following a respiratory viral infection. The evidence suggests that activation of this immune cell serves as an early switch that, when activated, drives progressive lung diseases, including asthma and chronic obstructive pulmonary disease (COPD).

Harmful Effects of E-cigarettes Long Known, But Researchers Want to Uncover More

Rockville, Md. (February 11, 2021)—The popularity of e-cigarettes continues to grow, especially among children and young adults. Some researchers have even suggested the devices are safer than traditional cigarettes. But a new research article published in the American Physiological Society’s…

University of Miami Health System and 4DMedical Launch Research Program Advancing Breakthrough Lung Technology

UHealth – the University of Miami Health System, the University of Miami Leonard M. Miller School of Medicine, and 4DMedical recently announced the creation of the Functional Lung Imaging Research Program in the Department of Medicine’s Division of Pulmonary, Critical Care and Sleep Medicine at the Miller School.

Bacterial Extracellular Vesicles from Poultry Farm Dust Causes Lung Inflammation in Mice

Article title: Bacterial extracellular vesicles isolated from organic dust induce neutrophilic inflammation in the lung Authors: Velmurugan Meganathan, Regina Moyana, Kartiga Natarajan, Weshely Kujur, Shilpa Kusampudi, Sachin Mulik, Vijay Boggaram From the authors: “In summary, our studies have found that…

Patients Hospitalized with Severe Cases of Flu Do Better Than Those With COVID-19

A new study published online in the Annals of the American Thoracic Society reveals how patients hospitalized with severe COVID-19 fared, compared to those hospitalized with severe seasonal influenza. The study is believed to be the first in the U.S. to directly compare clinical features, laboratory results and health outcomes between patients with the two diseases.

Healthy Lung Month: Know these pulmonary fibrosis risk factors

October is Healthy Lung Month, an apt time to educate the public about the importance of protecting our lungs against mold, airborne pollutants and smoking – which put hundreds of thousands of Americans at higher risk for pulmonary fibrosis (PF).

Researchers Identify “Druggable” Signaling Pathway that Stimulates Lung Tissue Repair

Researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have identified a cellular pathway that can be targeted with a naturally occurring drug to stimulate lung tissue regeneration, which is necessary for recovery from multiple lung injuries. The findings, which were published today in Nature Cell Biology, could lead to better therapies for patients with lung disease, including acute respiratory distress syndrome (ARDS) due to COVID-19.

Pulmonary Fibrosis Awareness Month Highlights Realities of Rare Disease

September’s Pulmonary Fibrosis Awareness Month shares crucial realities and insights about the rare disease, its symptoms and helpful resources provided by the Pulmonary Fibrosis Foundation to educate the public about this devastating disease which impacts over 200,000 Americans.

New Clinical Practice Guidelines on Non-Invasive Ventilation in Chronic Stable Hypercapnic COPD;

A subcommittee of the American Thoracic Society Assembly in Sleep and Respiratory Neurobiology has released new clinical practice guidelines to help advise clinicians on the optimal management of patients with chronic obstructive pulmonary disease (COPD) and chronic hypercapnia. Hypercapnia is the buildup of carbon dioxide in the bloodstream.

Chest X-Rays in Emergency Rooms Can Help Predict Severity of COVID-19 Illness in Young and Middle-aged Adults

Chest X-rays performed on young and middle-aged adults with COVID-19 when they arrive at the emergency room can help doctors predict who is at higher risk of severe illness and intubation, Mount Sinai researchers report.

Impaired Blood Clotting May Explain Higher COVID-19 Risk

A new review suggests that higher-than-normal levels of an enzyme involved in blood clot prevention may be a common risk factor for developing COVID-19—a respiratory disease caused by the novel coronavirus SARS-CoV-2—in some populations. The review is published in Physiological Reviews.

ECMO Physicians Offer Guidance in the Context of Resource-scarce COVID-19 Treatment

Rapidly escalating numbers of COVID-19 patients suffering from respiratory failure threaten to overwhelm hospital capacity and force healthcare providers into making challenging decisions about the care they provide. Of particular interest is the role of ECMO – extracorporeal membrane oxygenation, a form of life support for patients with advanced lung disease – to support critically ill patients in the current pandemic.

Coronavirus’ Binding Action May Also Cause Kidney Damage and Infertility; Researchers Consider Potential Treatment Paths

Article title: COVID-19 infection and mortality – A physiologist’s perspective enlightening clinical features and plausible interventional strategies Authors: Zaid A. Abassi, Karl Skorecki, Samuel Noam Heyman, Safa Kinaneh, Zaher Armaly From the authors: “Cleavage of the S-glycoprotein by furin and its…

‘Are Noncommunicable Diseases Communicable?’ Rutgers Experts Available to Discuss Paper in Science Today

New Brunswick, N.J. (Jan. 16, 2020) – Rutgers professors Maria Gloria Dominguez-Bello and Martin J. Blaser are available to discuss a paper in the journal Science today on whether diseases long thought to be noncommunicable – such as cardiovascular diseases, cancer…

Maternal Antibiotic Treatment May Harm Preemies’ Lungs

New research in mice suggests that exposure to antibiotics before birth may impair lung development in premature infants. The study, the first to explore the gut-lung axis in prematurity, is published ahead of print in the American Journal of Physiology—Lung Cellular and Molecular Physiology and was chosen as an APSselect article for December.

E-cigarettes Boost Infection Risk by Blocking Action of Immune Cells

A new study finds that e-cigarette vapor weakens the mobility and function of immune cells designed to fight infection. This reduced ability may increase the risk of bacterial illnesses in people who vape. The research is published ahead of print in the American Journal of Physiology—Cell Physiology.

Mount Sinai Researchers Develop Novel Method to Identify Patterns Among Patients With Multiple Chronic Conditions

A study by researchers at Icahn School of Medicine at Mount Sinai proposes a novel method for identifying patterns in the frequency and cost of multiple chronic conditions (MCC).

Expert Available to Discuss Dangers of Vaping and Associated Lung Illness

WHO: Keith S. Naunheim, MD, Vallee L. Melba Willman Professor and Chief of Cardiothoracic Surgery at Saint Louis University (SLU), and past president of The Society of Thoracic Surgeons WHY: The U.S. Food and Drug Administration and the U.S. Centers…

Experts @UCSDHealth & @UCSDMedSchool available to discuss dangers of #vaping and lung disease

In August, the Centers for Disease Control (CDC) issued a warning about a growing epidemic — lung injury caused by vaping. There have been more than 380 cases reported nationwide, with half of these patients requiring intensive care, and at…