DNA webs may drive lung pathology in severe COVID-19

Sticky webs of DNA released from immune cells known as neutrophils may cause much of the tissue damage associated with severe COVID-19 infections, according to two new studies published September 14 in the Journal of Experimental Medicine (JEM). The research, conducted by independent groups in Belgium and Brazil, suggests that blocking the release of these DNA webs could be a new therapeutic target for the management of severe forms of COVID-19.

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Unconventional T cells in severe COVID-19 patients could predict disease outcome

Researchers in France have discovered that patients suffering from severe COVID-19 show changes in a class of immune cells known as unconventional T cells. The study, published today in the Journal of Experimental Medicine (JEM), suggests that monitoring the activity of these cells in the blood of patients could predict the severity and course of the disease.

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Standardized Curriculum Introduces ICU Nurses to ECMO

Vanderbilt University Medical Center designed and rapidly deployed a curriculum specifically to equip nurses new to ECMO with the knowledge, skills and confidence necessary to provide proficient and safe care for patients receiving ECMO. The pre-COVID ECMO training proved to be an effective, resource-efficient and pragmatic solution that can be used across different types of ICUs and across institutions.

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Analysis Does Not Find Two Distinct Subphenotypes of COVID-19 Related ARDS

In a new paper published online in the Annals of the American Thoracic Society, researchers have been unable to produce two theorized subphenotypes of COVID-19 related acute respiratory distress syndrome (ARDS). Scientists previously proposed that two phenotypes exist that differentiate patients with more severe COVID-19 and indicate that they should be treated differently. A phenotype is a set of characteristics used to classify a patient, which may influence disease management.

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Simulation-based Training Helps Providers Prepare for Prone Position Ventilation for Patients With ARDS

An interprofessional simulation-based educational program helped Mount Sinai Hospital train nearly 90% of its medical ICU staff to care for patients in prone position, as part of its 2018 implementation of a new protocol related to prone position ventilation for patients with acute respiratory distress syndrome.

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