Mouse Study Suggests Androgens and Their Receptors Play Important and Positive Role in Asthma

Article title: Androgen receptor activation alleviates airway hyperresponsiveness, inflammation and remodeling in a murine model of asthma

Authors: Rama Satyanarayana Raju Kalidhindi, Nilesh Sudhakar Ambhore, Premanand Balraj, Taylor Schmidt, M. Nadeem Khan, Venkatachalem Sathish

From the authors: “Overall, our findings from the current study suggest [mixed allergen] exposure alters normal lung physiology by inducing major changes in [androgen receptor] expression, inflammation, remodeling, and contractility of airways leading to [airway hyperresponsiveness] and asthma.” 

This study is highlighted as one of May’s “best of the best” as part of the American Physiological Society’s APSselect program.