The impact of environmental conditions on the dynamic structures of RNAs in living cells has been revealed by innovative technology developed by researchers at the John Innes Centre.
Findings provide the foundation for future therapeutic strategies by promoting repair of the pulmonary vascular system.
New study concludes that boosting protein intake while dieting improves the quality of what we eat and may slow loss of lean body mass.
A collaborative study from UT Southwestern scientists has identified a new function for a protein called TAO2 that appears to be key to inhibiting replication of the influenza virus, which sickens millions of individuals worldwide each year and kills hundreds of thousands. The findings were published in PNAS.
Rutgers researcher, Grace Brannigan, has co-authored a study published in The Proceedings of the National Academy of Sciences (PNAS) that centers around the connection between gene mutations in protein sequences and diseases.
Article title: Albumin, oral contraceptives and venous thromboembolism risk in astronauts Authors: Sara R. Zwart, Serena M. Auñón-Chancellor, Martina Heer, M. Mark Melin, Scott M. Smith From the authors: “We report here evidence of an association between oral contraceptive use…
A team of international researchers has discovered a way to produce higher quality wheat. The scientists from the University of Adelaide and the UK’s John Innes Centre have identified a genetic driver that improves yield traits in wheat, which unexpectedly can also lead to increasing protein content by up to 25 per cent.
Because next-generation biofuels will depend on the growth and hardiness of woody feedstocks, scientists have sought to better understand how leaf cells quickly respond to environmental cues such as light, temperature and water. Scientists at the Center for Bioenergy Innovation, or CBI, have studied rapid molecular changes in leaves from poplar trees during normal daily cycles of daylight and darkness. Until now, the effect of these modifications at the cellular protein level was not well understood, partly because of the technical limitations of the analytical tools available.
Proteins are the molecular machinery that makes life possible, and researchers have long been interested in a key trait of protein function: their three-dimensional structure. A new study by Georgia Tech and Oak Ridge National Laboratory details a computational tool able to predict the structure protein complexes – and lends new insights into the biomolecular mechanisms of their function.
University of Washington and Microsoft researchers have introduced a new class of reporter proteins that can be directly read by a commercially available nanopore sensing device.
St. Jude Children’s Research Hospital scientists have created a model of the rare pediatric eye cancer that more closely mimics the biology of patient tumors.
St. Jude scientist Vibhor Mishra, Ph.D., is homing in on the location where important processes in gene regulation occur, and where single-stranded transcripts are converted into double-stranded RNAs (dsRNAs).
Steve Techtmann has won the 2021 Future Insight Prize — awarded to innovative research in health, nutrition and energy — for his food generator concept.
Using DNA, scientists organized bioactive proteins in desired 2-D and 3-D ordered arrays—promising for structural biology, biomedicine, and more.
One specific protein may be a master regulator for changing how cancer cells consume nutrients from their environments, preventing cell death and increasing the likelihood the cancer could spread, a study from the University of Notre Dame has shown.
Using genetic engineering, researchers at UT Southwestern and Indiana University have reprogrammed scar-forming cells in mouse spinal cords to create new nerve cells, spurring recovery after spinal cord injury. The findings, published online today in Cell Stem Cell, could offer hope for the hundreds of thousands of people worldwide who suffer a spinal cord injury each year.
A nuclear war could trigger an unprecedented El Niño-like warming episode in the equatorial Pacific Ocean, slashing algal populations by 40 percent and likely lowering the fish catch, according to a Rutgers-led study. The research, published in the journal Communications Earth & Environment, shows that turning to the oceans for food if land-based farming fails after a nuclear war is unlikely to be a successful strategy – at least in the equatorial Pacific.
DALLAS – Jan. 25, 2021 – Small cell lung cancer (SCLC) cells are missing a surface protein that triggers an immune response, allowing them to hide from one of the body’s key cancer defenses, a new study led by UT Southwestern researchers suggests. The findings, reported online today in Cancer Research, a journal of the American Association for Cancer Research, could lead to new treatments for SCLC, which has no effective therapies.
University of Washington researchers developed a technique to modify naturally occurring biological polymers with protein-based biochemical messages to affect cell behavior. Their approach uses near-infrared lasers to trigger chemical adhesion of proteins to scaffolds made from biological polymers like collagen.
Irvine, Calif., Dec. 17, 2020 — Reflectins, the unique structural proteins that give squids and octopuses the ability to change colors and blend in with their surroundings, are thought to have great potential for innovations in areas as diverse as electronics, optics and medicine. Scientists and inventors have been stymied in their attempts to fully utilize the powers of these biomolecules due to their atypical chemical composition and high sensitivity to subtle environmental changes.
A new study at the University of Chicago has shown that elaborate protein structures accumulate over deep time even when they serve no purpose, because a universal biochemical property and the genetic code force natural selection to preserve them.
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Tuesday.
New research published in the journal Function identifies NKCC1, the protein responsible for moving sodium, potassium and chloride into cells, to be a cause of disease and dysfunction throughout the body. NKCC1 is encoded by the gene SLC12A2. Human and…
After a nuclear war, wild-catch marine fisheries will not offset the loss of food grown on land, especially if widespread overfishing continues, according to a Rutgers co-authored study. But effective pre-war fisheries management would greatly boost the oceans’ potential contribution of protein and nutrients during a global food emergency, according to the study in the journal Proceedings of the National Academy of Sciences. The study for the first time explored the effects of nuclear war on wild-catch marine fisheries.
Through large-scale profiling of protein changes in response to drug treatments in cancer cell lines, researchers at The University of Texas MD Anderson Cancer Center have generated a valuable resource to aid in predicting drug sensitivity, to understand therapeutic resistance mechanisms and to identify optimal combination treatment strategies.
COVID-19 is caused by the virus SARS-CoV-2, which is structurally similar to the viruses that cause SARS-CoV and MERS-CoV. In The Journal of Chemical Physics, scientists report molecular-level investigations of these viruses, providing a possible pathway to antiviral drugs to fight the diseases. They looked at a viral protein that plays a role in the virus’s ability to replicate and in defeating the host’s immune system, making it an attractive target for potential drug treatments.
Article title: Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice Authors: Vishal Singh, Sarah Galla, Rachel M. Golonka, Andrew D. Patterson, Benoit Chassaing, Bina Joe, Matam Vijay-Kumar From the authors: “Overall, the current study demonstrates that…
With global food demands rising at an alarming rate, a study led by IUPUI scientists has found new evidence that the yellow mealworm shows promise as alternative source of nutritional protein.
Groundbreaking cancer research by the University of South Australia has identified an invasive protein molecule that could be responsible for some of the most aggressive breast cancers.
Researchers from the National University of Singapore have identified a new avenue to maintain bone health, which opens up new and potentially more effective osteoporosis treatments.
In severe cases of COVID-19, damage can spread beyond the lungs and into other organs, such as the heart, liver, kidney and parts of the neurological system. Beyond these specific sets of organs, however, the virus seems to lack impact. Ernesto Estrada aimed to uncover an explanation as to how it is possible for these damages to propagate selectively rather than affecting the entire body. He discusses his findings in the journal Chaos.
Lawrence Livermore National Laboratory (LLNL) researchers, in collaboration with Pennsylvania State University (PSU) and Idaho National Laboratory (INL), have designed a new process, based on a naturally occurring protein, that could extract and purify rare earth elements (REE) from low-grade sources. It could offer a new avenue toward a more diversified and sustainable REE sector for the United States. The protein, lanmodulin, enables a one-step extraction and purification of (REE)s from complex metal mixtures, including electronic waste and coal byproducts.
As the COVID-19 pandemic continues to spread, many researchers are studying epidemiological models to predict its propagation. However, a mathematician and expert in complex systems decided to focus on finding targets within SARS-CoV-2 for new drugs to attack. In the journal Chaos, he discusses the dramatic increase in the sensitivity of the main protease of SARS-CoV-2 to small disturbances, which made him suspect there is a role for inhibitors to play in killing the virus.
Scientists open doors to new treatment possibilities by using a metal complex to accelerate serum albumin protein destruction with infrared laser beams
Algae in the oceans often steal genes from bacteria to gain beneficial attributes, such as the ability to tolerate stressful environments or break down carbohydrates for food, according to a Rutgers co-authored study.
The study of 23 species of brown and golden-brown algae, published in the journal Science Advances, shows for the first time that gene acquisition had a significant impact on the evolution of a massive and ancient group of algae and protists (mostly one-celled organisms including protozoa) that help form the base of oceanic food webs.
Proteins are the building blocks of life and scientists have long studied how to improve them or design new ones. Traditionally, new proteins are created by mimicking existing proteins or manually editing their amino acids. This process is time-consuming, and it is difficult to predict the impact of changing an amino acid. In APL Bioengineering, researchers explore how to create new proteins by using machine learning to translate protein structures into musical scores, presenting an unusual way to translate physics concepts across domains.
New research from the University of Notre Dame shows these silent mutations are worth a closer look.
A recent study from the George Washington University suggests that the innate protein AIBP restricts HIV-1 replications by targeting the lipid rafts the virus relies on.
Genetic engineering makes cotton seeds safe for human consumption
Using advanced computational methods to find working designs, researchers created six protein pairs in cells.
Researchers have identified a protein in foxtail millet that can help stave off atherosclerosis in mice genetically prone to the disease. They report their results in ACS’ Journal of Agricultural and Food Chemistry.
Protein purification is a multibillion-dollar industry. A new purification process developed by Michigan Tech biochemists, called capture and release (CaRe), is a lot like catch and release fishing. It comes down to the picking the right lure to bait a specific protein and CaRe speeds up protein purification while also lowering costs.
Protein editorial assistants are clearing the way for cut-and-paste DNA editors, like CRISPR, to access previously inaccessible genes of interest. Opening up these areas of the genetic code is critical to improving CRISPR efficiency and moving toward futuristic, genetic-based assaults on disease. The DNA-binding editorial assistants were devised by a U.S.-based team of bioengineers, who describe their design in APL Bioengineering.
A Rutgers-led team may have found the key to preventing Duchenne muscular dystrophy (DMD)-related heart disease, the leading cause of death in patients living with the disease
New research from Arizona State University shows that consuming mung bean protein can improve physical strength — no exercise required.
The U.S. Food and Drug Administration has given the green light to ultra-low gossypol cottonseed, ULGCS, to be utilized as human food and in animal feed, something Texas A&M AgriLife researchers have been working on for nearly 25 years.
Scientists from Rutgers University and around the world have discovered an antibiotic produced by a soil bacterium from a Mexican tropical forest that may help lead to a “plant probiotic,” more robust plants and other antibiotics. Probiotics, which provide friendlier bacteria and health benefits for humans, can also be beneficial to plants, keeping them healthy and more robust. The new antibiotic, known as phazolicin, prevents harmful bacteria from getting into the root systems of bean plants, according to a Rutgers co-authored study in the journal Nature Communications.
Using the Titan supercomputer and the Spallation Neutron Source at the Department of Energy’s Oak Ridge National Laboratory, scientists have created the most accurate 3D model yet of an intrinsically disordered protein, revealing the ensemble of its atomic-level structures.
In a study published online in the International Journal of Cardiology, researchers at Beth Israel Deaconess Medical Center (BIDMC) examined the effects of three healthy diets emphasizing different macronutrients – carbohydrates, proteins, or unsaturated fats – on a biomarker that directly reflects heart injury. The team found that all three diets reduced heart cell damage and inflammation, consistent with improved heart health.