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UrduA UCLA-led study involving mice and human data could also have implications for individuals with diabetes and obesity, uncovering new treatment possibilities for life-threatening arrhythmias.
Tag: Gene Mutations
Using Advanced Genetic Techniques, Scientists Create Mice With Traits of Tourette Disorder
In research that may be a step forward toward finding personalized treatments for Tourette disorder, scientists at Rutgers University–New Brunswick have bred mice that exhibit some of the same behaviors and brain abnormalities seen in humans with the disorder. As reported in the Proceedings of the National Academy of Sciences, the researchers, using a technique known as CRISPR/Cas9 DNA editing, inserted the same genetic mutations found in humans with Tourette disorder into the corresponding genes in mouse embryos.
Study Unlocks New Insight about Breast Cancer Risk
A new study led by a researcher at New York Institute of Technology provides insight that could change how scientists and clinicians understand genetic predisposition to breast cancer, a condition that affects one in eight U.S. women in her lifetime.
Researchers uncover how a genetic mutation can cause individuals with normal cholesterol levels to develop coronary artery disease at a young age
A novel molecular pathway to explain how a mutation in the gene ACTA2 can cause individuals in their 30s – with normal cholesterol levels and no other risk factors — to develop coronary artery disease has been identified, according to researchers with UTHealth Houston.
Staph infection-induced kidney disease may be linked to bacterial gene mutation
Researchers aiming to predict which staph-infection patients might develop a related kidney disease have found a high frequency of gene mutations in the infecting bacteria of affected patients, which suggests these variants may play a role in the body’s initiation of the renal damage.
Iron Buildup in Brain Linked to Higher Risk for Movement Disorders
UC San Diego researchers report that individuals with two copies of a gene mutation show evidence of substantial iron buildup in regions of the brain, raising risk for movement disorders like Parkinson’s disease.
Rutgers Researchers Publish Paper Examining the Structure of Proteins Linked to Diseases
Rutgers researcher, Grace Brannigan, has co-authored a study published in The Proceedings of the National Academy of Sciences (PNAS) that centers around the connection between gene mutations in protein sequences and diseases.
Cedars-Sinai Investigators ID Gene Critical to Human Immune Response
Cedars-Sinai investigators have identified a gene that plays an essential role in the innate human immune system. The gene, NLRP11, helps activate the inflammatory response that tells the body’s white blood cells to go on the attack against a foreign presence.
Summit Charts a Course to Uncover the Origins of Genetic Diseases
Gene mutations can interfere with how the body expresses genes and cause disease. To better understand this connection, researchers recently developed a model of the transcription preinitiation complex (PIC).