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New understanding of why kidney cancers become metastatic discovered by MD Anderson researchers

June 26, 2023 sarah JonasResearch Results

Researchers at The University of Texas MD Anderson Cancer have engineered a new model of aggressive renal cell carcinoma (RCC), highlighting molecular targets and genomic events that trigger chromosomal instability and drive metastatic progression.
The study, published today in Nature Cancer, demonstrates that the loss of a cluster of interferon receptor (IFNR) genes plays a pivotal role in allowing cancer cells to become tolerant of chromosomal instability. This genomic feature may be used to help clinicians predict a tumor’s potential to become metastatic and treatment resistant.

MD Anderson Research Highlights for June 7, 2023

June 7, 2023 sarah JonasResearch Tip Sheet

The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention.

Establishing cell lines to improve iPSC research

February 2, 2023 sarah JonasResearch Results

iPSC lines have become essential for determining the underlying genetic drivers of human disease.

Cedars-Sinai Investigators ID Gene Critical to Human Immune Response

May 27, 2022 sarah JonasResearch Results

Cedars-Sinai investigators have identified a gene that plays an essential role in the innate human immune system. The gene, NLRP11, helps activate the inflammatory response that tells the body’s white blood cells to go on the attack against a foreign presence.

Scientists Use DNA Origami to Monitor CRISPR Gene Targeting

February 23, 2021 sarah JonasResearch Results

ROCKVILLE, MD – The remarkable genetic scissors called CRISPR/Cas9, the discovery that won the 2020 Nobel Prize in Chemistry, sometimes cut in places that they are not designed to target.

Xenobiotic Receptor Activation, CRISPR/Cas9, Magnetic Resonance-Guided Radiotherapy, and More Featured in May 2020 Toxicological Sciences

May 7, 2020 sarah JonasResearch Tip Sheet

During these difficult times, the Society of Toxicology’s official journal, Toxicological Sciences, remains a source for leading research in toxicology, including in the areas of biomarkers, carcinogenesis, and organ-specific toxicology.