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UrduTitin is a “titanically large” protein – the largest in the human body – which enables elastic movements of our muscles, including the heart.
Tag: Heart Disease
American Heart Association Honors Two Penn Medicine Scientists for Achievements in Research
Two Penn Medicine faculty members, Kiran Musunuru, MD, PhD, and Daniel Rader, MD, are being honored with prestigious awards from the American Heart Association (AHA) for their achievements in cardiovascular research. Both awards will be presented during the Presidential Session on Sunday, Nov. 14, at the association’s Scientific Sessions 2021.
Penn Study Illuminates the Biology of Common Heart Disorder
Dilated cardiomyopathy due to titin gene mutations involves both a shortage of good titin and a buildup of mutant, potentially “bad” titin
CRF Announces Free Online Access to TCT 2021
The Cardiovascular Research Foundation (CRF) is pleased to announce that the digital component of TCT 2021 will now be free for the entire interventional community. After careful consideration and achieving a critical level of support, CRF’s leadership has agreed to fully support this initiative. Complimentary online registration will include access to all content via livestream during the meeting and on-demand access for one year.
Low-dose Aspirin No Longer Recommended to Prevent Cardiovascular Disease
New draft recommendations from the U.S. Preventive Services Task Force recommend against taking aspirin to prevent heart attacks and strokes for most people. The Oct. 12, 2021 guidelines are based on new evidence showing that the risks of daily low-dose…
Researchers Look to Deleted Mitochondrial Protein to Treat Heart Disease
Article title: Loss of the mitochondrial phosphate carrier SLC25A3 induces remodeling of the cardiac mitochondrial protein acylome Authors: Jessica N. Peoples, Nasab Ghazal, Duc M. Duong, Katherine R. Hardin, Janet R. Manning, Nicholas T. Seyfried, Victor Faundez, Jennifer Q. Kwong…
Meeting sleep recommendations could lead to smarter snacking
Missing out on the recommended seven or more hours of sleep per night could lead to more opportunities to make poorer snacking choices than those made by people who meet shut-eye guidelines, a new study suggests.
CRF Announces TCT 2021 Late-Breaking Trials and Science
The Cardiovascular Research Foundation (CRF) has announced 22 late-breaking trial and science presentations that will be reported at TCT 2021. TCT is the annual scientific symposium of CRF and the world’s premier educational meeting specializing in interventional cardiovascular medicine. It will take place November 4-6, 2021 in Orlando, Florida at the Orange County Convention Center and simultaneously broadcast live.
Memorial Hermann First in Texas to Use Newly-Approved Device to Treat Atrial Fibrillation in Patients at Risk of Stroke
Memorial Hermann in Houston, TX is the first institution in Texas to use a new device to treat AFib in patients at risk of stroke.
‘Leaky’ Heart Valves in Pregnant Women Need More Attention Than Once Thought, Study Suggests
An analysis of more than 20,000 individual medical records suggests that a form of heart valve disease thought to be relatively benign during pregnancy may put women at risk for serious bleeding, high blood pressure, organ damage and other complications during childbirth, according to research from Johns Hopkins Medicine.
Having MS Plus Depression May Be Tied to Increased Risk of Death
Depression is common in people with multiple sclerosis (MS), and a new study shows that people with both conditions may be more likely to die over the next decade than people with just one or neither condition. The study is published in the September 1, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study also found that people with MS and depression have an increased risk of developing vascular disease such as heart attack and stroke.
Diverse DNA signatures linked to heart disease
Risk for heart disease does not look the same on the genetic level for different population groups, report an international team of researchers this month in the journal JAMA Cardiology. The study, led by Texas Biomedical Research Institute (Texas Biomed) and Columbia University Mailman School of Public Health, begins to outline gene activity patterns that could serve as early warning indicators for cardiovascular disease.
Examining Correlation Between Occupational Noise, Heart Disease
Hearing conservation programs and policies aim to protect workers from noise-induced hearing loss, but it remains unclear whether stress reactions caused by noise exposure might also lead to other negative health outcomes. In The Journal of the Acoustical Society of America, researchers describe how data from the Canadian Health Measures Survey do not support an association between loud noise exposure and changes in biomarkers for cardiovascular disease or outcomes.
Muscle Protein That Makes Vertebrates More Fit Linked to Limited Lifespan
Researchers from Johns Hopkins Medicine say they have added to evidence that a protein called CaMKII improves strength, endurance, muscle health and fitness in young animals. Their experiments working with mice and fruit flies, however, found that the gene for CaMKII also contributes to an evolutionary tradeoff: increased susceptibility to age-associated diseases, frailty and mortality.
Eating More Plant Foods May Lower Heart Disease Risk in Young Adults, Older Women
Eating more nutritious, plant-based foods is heart-healthy at any age, according to two research studies published today in the Journal of the American Heart Association, an open access journal of the American Heart Association.
Most Comprehensive Review Yet of Keto Diets Finds Heart Risks, Cancer Risk, Dangers to Pregnant Women and Kidney Patients
In the most comprehensive analysis yet of ketogenic (keto) diets, a review in Frontiers in Nutrition finds keto diets place pregnant women and kidney disease patients at risk of adverse health effects.
Clinical Trial Shows Injectable Weight Loss Drug Directly Reduces Abdominal Fat
A clinical trial found liraglutide, an injectable weight loss medication, reduced intra-abdominal and liver fat in participants more than placebo in addition to a low-calorie diet and increased physical activity.
NYU Langone Health Named Coordinating Center for American Heart Association Health Equity Research Network to Prevent Hypertension in Black Communities
As part of a $20 million award from the America Heart Association, NYU Grossman School of Medicine has been named as the coordinating center for a new collaboration between eight universities to prevent hypertension and reduce racial inequities in cardiovascular disease outcomes in Black communities.
Heart Cell Protein Could Lead to New Treatments for Heart Failure and Recovery
A protein that helps regulate calcium signaling within heart cells could play a key role in preventing chronic heart failure, according to an international study led by University of Utah Health scientists. T The finding suggests that drugs and other therapeutic treatments targeting this protein could eventually help alleviate heart failure.
Mount Sinai Recruits Internationally Recognized Cardiovascular Immunology Researcher
Filip Swirski, PhD, named Director of Mount Sinai’s new Cardiovascular Research Institute
Penn Medicine-Led Research Team Awarded $2.9 Million to Study Heart Disease and Cancer in Black and Hispanic Communities
The Cardio-Oncology Translational Center of Excellence at Penn Medicine has been awarded $2.9 million by the American Heart Association as part of a larger effort to reduce disparities in cardio-oncology and increase understanding of cardiovascular disease among cancer patients and survivors from minority populations. As part of this newly established research program, scientists from the University of Pennsylvania and other institutions will study patients with breast or prostate cancer, the most common cancers in women and men, respectively, with a focus on Black and Hispanic communities.
Fat Tissue Protein Signaling May Lead to Treatment to Improve Heart Health in People Who Can’t Exercise
Article title: Aerobic exercise training reduces cardiac function and coronary flow-induced vasodilation in mice lacking adiponectin Authors: Jacob T. Caldwell, Karissa M. Dieseldorff Jones, Hyerim Park, Jose R. Pinto, Payal Ghosh, Emily C. Reid-Foley, Brody Ulrich, Michael D. Delp, Brad…
Prem Shekar, MD, named chair of Cardiac and Thoracic Surgery at Lahey Hospital & Medical Center
Shekar will lead the department’s efforts to treat patients with cutting edge surgical approaches, train the next generation of cardiothoracic surgeons and move the field forward through rigorous research.
Protein linked to heart health, disease a potential therapeutic target for dementia
Researchers at Washington University School of Medicine in St. Louis have found that high levels of a normal protein associated with reduced heart disease also protect against Alzheimer’s-like damage in mice, opening up new approaches to slowing or stopping brain damage and cognitive decline in people with Alzheimer’s.
Smokers needed angioplasty and stenting a decade before non-smokers
Smokers needed their blocked arteries fixed nearly a decade earlier than non-smokers, and patients with obesity underwent these procedures four years earlier than non-obese patients, according to a new study from across Michigan.
Most Americans Are Not Getting Enough Fiber in Our Diets
Only 5% of men and 9% of women are getting the recommended daily amount of dietary fiber, according to a study being presented at NUTRITION 2021 LIVE ONLINE. Insufficient fiber intake is associated with a higher risk of heart disease and diabetes, two of the most common diseases in the U.S.
Two Mount Sinai Leaders Receive Prestigious Honors from American Heart Association in New York City
Two of Mount Sinai’s top doctors will be honored with prestigious awards at the American Heart Association’s New York City Heart and Stroke Ball, taking place virtually on Wednesday, June 9.
Milk makeover: a great start for a healthy heart
A dash of milk could make all the difference to a healthy heart as new research from the University of South Australia finds that people who regularly consume milk have a lower risk of heart disease.
People who eat a plant-based dinner could reduce their risk of heart disease by ten percent
People who eat too many refined carbs and fatty meats for dinner have a higher risk of heart disease than those who eat a similar diet for breakfast, according to a nationwide study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
Fat Around the Heart Linked to Increased Risk of Heart Failure
EMBARGOED UNTIL MAY 24 2:00PM EST (New York, NY – May 24, 2021) – Having excess pericardial fat—fat around the heart—increases the risk of developing heart failure, especially in women, according to new Mount Sinai research. Women with high amounts…
Study of AI-enabled EKGs finds that a difference between numerical age and biological age significantly affects health, longevity
You might be older ― or younger ― than you think. A new study found that differences between a person’s age in years and his or her biological age, as predicted by an artificial intelligence (AI)-enabled EKG, can provide measurable insights into health and longevity.
Compound May Prevent Arrhythmia Caused by Medicines
A team of researchers including Ira S. Cohen, MD, PhD, of the Renaissance School of Medicine at Stony Brook University, has identified a compound that prevents the lengthening of the heart’s electrical event which can cause a lengthening of the EKG’s Q-T interval and a sometimes deadly arrhythmia.
Molecular Alteration May Be Cause — Not Consequence — of Heart Failure
Clinicians and scientists have long observed that cells in overstressed hearts have high levels of the simple sugar O-GlcNAc modifying thousands of proteins within cells. Now, researchers at Johns Hopkins Medicine have found evidence in mouse experiments that these excess sugars could well be a cause, not merely a consequence or marker of heart failure.
Study Explores Mitochondrial Resilience in Adult Heart after Ablation
Article title: Mitochondrial functional resilience after TFAM ablation in the adult heart Authors: Nasab Ghazal, Jessica N. Peoples, Tahmina A. Mohiuddin, Jennifer Q. Kwong From the authors: “Our study highlights the need to delineate mitochondrial maintenance pathways in both developing…
The Medical Minute: When is a visit to a pediatric cardiologist in order?
Parents shouldn’t ignore sometimes subtle warning signs of a structural heart defect or heart condition. Dr. Stephen Cyran, pediatric cardiologist with Penn State Health Children’s Heart Group, explains in this Medical Minute.
A Shocking, New Treatment for Heart Disease
Barbara Colella and her cardiologist, Dr. Haroon Faraz, have a lot to smile about today. Barbara was one of the first patients in New Jersey to undergo an exciting, new treatment for coronary heart disease, the leading cause of death…
Experimental Biology 2021 Press Materials Available Now
Embargoed press materials are now available for the virtual Experimental Biology (EB) 2021 meeting, featuring cutting-edge multidisciplinary research from across the life sciences. EB 2021, to be held April 27–30, is the annual meeting of five scientific societies bringing together thousands of scientists and 25 guest societies in one interdisciplinary community.
Announcing Virtual Press Conference for Experimental Biology 2021 Meeting
Reporters are invited to join a live Q&A discussion of exciting research announcements at the forefront of the life sciences during a virtual press conference for the Experimental Biology (EB) 2021 meeting. The press conference will be held online from 1–1:45 p.m. EDT on Monday, April 26, 2021 (RSVP by Friday, April 23).
Johns Hopkins Medicine Expert Creates Comprehensive Guide to New Diabetes Drugs
New medicines for people who have diabetes seem to pop up all the time. Drugs that help the body break down carbohydrates, drugs that increase excretion of glucose in the urine, drugs that help muscles respond to insulin and drugs that stimulate the pancreas to produce it — the list of pharmaceutical options to treat diabetes gets longer and longer.
Time to Shift from “Food Security” to “Nutrition Security” to Increase Health & Well-Being
A new Viewpoint article argues that today’s health and equity challenges call for the U.S. to shift from “food insecurity” to “nutrition insecurity” in order to catalyze appropriate focus and policies on access not just to food but to healthy, nourishing food.
Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Wednesday.
Should you take fish oil? Depends on your genotype
Fish oil supplements are a billion-dollar industry built on a foundation of purported, but not proven, health benefits. Now, new research from a team led by a University of Georgia scientist indicates that taking fish oil only provides health benefits if you have the right genetic makeup.
Cancer survivors face elevated heart disease risk, study finds
A new study has found that about 35% of Americans with a cancer history had an elevated risk of cardiovascular disease in the next decade, compared with about 23% of those who didn’t have cancer.
Genetic testing proves beneficial in prescribing effective blood thinners
A new research paper funded in part by the National Heart, Lung and Blood Institute (NHLBI) shows a clear advantage of genetic testing in helping health care providers choose the appropriate anti-platelet drug. Testing helps determine if a patient carries genetic variants in CYP2C19 that cause loss of its function. These variants interfere with the body’s ability to metabolize and activate clopidogrel, an anti-platelet medication.
In women, higher body fat may protect against heart disease death, study shows
A new UCLA study shows that while men and women who have high muscle mass are less likely to die from heart disease, it also appears that women who have higher levels of body fat — regardless of their muscle mass — have a greater degree of protection than women with less fat.
Hassenfeld Children’s Hospital at NYU Langone Health Unveils New Comprehensive Pediatric Congenital Heart Center
State-of-the-Art Facility and Multidisciplinary Team Approach Expands Care for Children with Complex Congenital Heart Defects
Accelerating Gains in Abdominal Fat During Menopause Tied to Heart Disease Risk
Women who experience an accelerated accumulation of abdominal fat during menopause are at greater risk of heart disease, even if their weight stays steady, according to a University of Pittsburgh Graduate School of Public Health-led analysis published today in the journal Menopause.
Using Stimuli-Responsive Biomaterials to Understand Heart Development, Disease
The heart cannot regenerate new tissue, because cardiomyocytes, or heart muscle cells, do not divide after birth. However, researchers have now developed a shape memory polymer to grow cardiomyocytes. Raising the material’s temperature turned the polymer’s flat surface into nanowrinkles, which promoted cardiomyocyte alignment. The research is part of the growing field of mechanobiology, which investigates how physical forces between cells and changes in their mechanical properties contribute to development, cell differentiation, physiology, and disease.
Exercise Improves Blood Vessel Dysfunction Caused by Lack of Sleep
Article title: Regular aerobic exercise counteracts endothelial vasomotor dysfunction associated with insufficient sleep Authors: Kelly A. Stockelman, Anthony R. Bain, Caitlin A. Dow, Kyle J. Diehl, Jared J. Greiner, Brian L. Stauffer, Christopher A. DeSouza From the authors: “Regular aerobic…
Shift Work Disrupts Kidney Rhythms, Contributes to Kidney and Heart Disease
Article title: Environmental circadian disruption suppresses rhythms in kidney function and accelerates excretion of renal injury markers in urine of male hypertensive rats Authors: Atlantis M. Hill, G. Ryan Crislip, Adam Stowie, Ivory Ellis, Anne Ramsey, Oscar Castanon-Cervantes, Michelle L.…