Scientists trace the molecular roots of potentially fatal heart condition

At a glance:

Research using heart cells from squirrels, mice and people identifies an evolutionary mechanism critical for heart muscle function

Gene defect that affects a protein found in the heart muscle interferes with this mechanism to cause hypertrophic cardiomyopathy, a potentially fatal heart condition

Imbalance in the ratio of active and inactive protein disrupts heart muscle’s ability to contract and relax normally, interferes with heart muscle’s energy consumption

Treatment with a small-molecule drug restores proper contraction, energy consumption in human and rodent heart cells

If affirmed in subsequent studies, the results can inform therapies that could halt disease progression, help prevent common complications, including arrhythmias and heart failure

Can the state of Alabama conquer its biggest health challenges? It’s a Grand Challenge, and one state university is determined to prevail

For far too long, Alabama’s residents have seen their health statuses languish when compared to those of other states. Often, Alabama is a punchline when it comes to obesity, diabetes and the overall health of its people. But the consequences, unfortunately, are counted in decreased quality of life, increased health costs and lives lost — hardly a laughing matter.

Stem Cell Therapy Helps Broken Hearts Heal in Unexpected Way

A study in Nature shows stem cell therapy helps hearts recover from a heart attack, although not for the biological reasons originally proposed two decades ago that today are the basis of ongoing clinical trials. The study reports that injecting living or even dead heart stem cells into the injured hearts of mice triggers an acute inflammatory process, which in turn generates a wound healing-like response to enhance the mechanical properties of the injured area.

Study finds associations between rheumatoid arthritis, other diseases before and after diagnosis

A Mayo Clinic-led study involving 3,276 patients has found that people with inflammatory bowel disease, Type 1 diabetes or blood clots may be at increased risk of developing rheumatoid arthritis. The study, published in Mayo Clinic Proceedings, also found that people who have rheumatoid arthritis are at increased risk of developing heart disease, blood clots and sleep apnea.

People in Counties with Worse Economies Post-Recession Are More Likely to Die from Heart Disease

Communities in the United States that experienced the most economic distress in the wake of the Great Recession saw a significant increase in death rates from heart disease and strokes among middle-aged people, according to a new multi-institution study led by researchers at Penn Medicine.

Omega-3 Continues to Show Protection Against Heart Disease-Related Death, Without Prostate Cancer Risk

Should you take omega-3 pills? Or try to have two to servings of omega-3 rich fish a week, as the American Heart Association recommends? It may seem a bit murky if you follow headlines about nutrition and health. That’s why researchers at the Intermountain Healthcare Heart Institute continue to research the potential benefits and risks of this popular supplement, especially when it comes to prostate cancer risk and heart health.

“Nudging” Heart Patients to Take Their Statins Leads to Better Medication Adherence and Better Patient Outcomes

In a new study presented to heart specialists from around the world, researchers at the Intermountain Healthcare Heart Institute in Salt Lake City found that simple “nudges” in the form of texts, emails and phone calls, not only help patients fill that first statin prescription, but also continue to help them take their medications over the long term.

Better Biosensor Technology Created for Stem Cells

A Rutgers-led team has created better biosensor technology that may help lead to safe stem cell therapies for treating Alzheimer’s and Parkinson’s diseases and other neurological disorders. The technology, which features a unique graphene and gold-based platform and high-tech imaging, monitors the fate of stem cells by detecting genetic material (RNA) involved in turning such cells into brain cells (neurons), according to a study in the journal Nano Letters.

Teaching Preschool Caregivers about Healthy Behaviors May Promote Healthier Lifestyle in Some High-Risk Groups

Study Shows Vascular Ultrasounds and Adhering to Interventional Education in Underserved Communities can Improve Health among Parents and School Staff

MIDDLE-AGED ADULTS WITH BORDERLINE PERSONALITY DISORDER POTENTIALLY AT HIGHER RISK FOR HEART ATTACKS, STUDY SAYS

Middle-aged adults who show symptoms of borderline personality disorder may be at greater risk for a heart attack, as they show physical signs of worsening cardiovascular health more than other adults, according to research published by the American Psychological Association.

Pairing New Medications Could Offer Hope to Heart Disease Patients

Cardiologist Bertram Pitt, MD, sees promise in combining two new classes of medication into a treatment regimen for patients with cardiovascular disease. Pitt will discuss the advantages of this treatment plan in his plenary lecture at an American Physiological Society Conference in Estes Park, Colo.

Skin-Cells-Turned-to-Heart-Cells Help Unravel Genetic Underpinnings of Cardiac Function

A small genetic study, published September 30, 2019 in Nature Genetics, identified a protein linked to many genetic variants that affect heart function. Researchers are expanding the model to other organ systems and at larger scales to create a broader understanding of genes and proteins involved.

Researchers to Discuss Hormonal and Sodium-related Factors of Cardiovascular Disease at APS Conference

International physiologists and researchers studying the kidney, high blood pressure and related medical conditions will convene next week at the American Physiological Society (APS) Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference in Estes Park, Colo.

Mummy study: Heart disease was bigger issue for human ancestors than initially thought

A new imaging study of the mummified arteries of people who lived thousands of years ago revealed that their arteries were more clogged than originally thought, according to a proof-of-concept study led by a researcher with The University of Texas Health Science Center at Houston (UTHealth). It is in the October print edition of the American Heart Journal.

Choices of the Heart: Healthy Foods More Important than Type of Diet to Reduce Heart Disease Risk

In a study published online in the International Journal of Cardiology, researchers at Beth Israel Deaconess Medical Center (BIDMC) examined the effects of three healthy diets emphasizing different macronutrients – carbohydrates, proteins, or unsaturated fats – on a biomarker that directly reflects heart injury. The team found that all three diets reduced heart cell damage and inflammation, consistent with improved heart health.

Announcing the TCT 2019 Late-Breaking Trials and Science

The Cardiovascular Research Foundation (CRF) has announced the 12 late-breaking trials and 16 late-breaking science presentations that will be reported at the Transcatheter Cardiovascular Therapeutics (TCT) 2019 scientific symposium. TCT, the world’s premier educational meeting specializing in interventional cardiovascular medicine, will take place September 25 – 29, 2019 at The Moscone Center in San Francisco, California.