The malaria drug hydroxychloroquine, which has been promoted as a potential treatment for Covid-19, is known to have potentially serious effects on heart rhythms. Now, a team of researchers has used an optical mapping system to observe exactly how the drug creates serious disturbances in the electrical signals that govern heartbeat.Read more
Researchers invented a microfluidic chip containing cardiac cells that is capable of mimicking hypoxic and other conditions following a heart attack. The chip can be used to monitor electrophysiological and molecular response of the cells to heart attack conditions in real time.Read more
Low oxygen levels in the heart have long been known to produce life-threatening arrhythmias, even sudden death. Until now, it was not clear how.
New findings, in a study led by Steve A. N. Goldstein, MD, PhD, vice chancellor for Health Affairs at the University of California, Irvine, and distinguished professor in the UCI School of Medicine Departments of Pediatrics and Physiology & Biophysics, reveal the underlying mechanism for this dangerous heart disorder.
At a glance:
Research using heart cells from squirrels, mice and people identifies an evolutionary mechanism critical for heart muscle function
Gene defect that affects a protein found in the heart muscle interferes with this mechanism to cause hypertrophic cardiomyopathy, a potentially fatal heart condition
Imbalance in the ratio of active and inactive protein disrupts heart muscle’s ability to contract and relax normally, interferes with heart muscle’s energy consumption
Treatment with a small-molecule drug restores proper contraction, energy consumption in human and rodent heart cells
If affirmed in subsequent studies, the results can inform therapies that could halt disease progression, help prevent common complications, including arrhythmias and heart failureRead more