news, journals and articles from all over the world.
In a University of Illinois lab in the 1980s, Steve Maren heard neurons fire for the first time. His research trajectory snapped into place like an amygdala-shaped arrow. In August 2024, Maren became director of the Beckman Institute for Advanced Science…
Symptoms progression of Rett syndrome are different in females than males. A new MIND Institute study shows why it is important to understand these differences to develop better treatments.
The University of Chicago, Chicago State University, and the University of Illinois Chicago received a $4.8 million grant from the NIH BRAIN Initiative to build a faster microscope for mapping all the connections in the brain.
New mouse model research led by scientists at The Ohio State University Wexner Medical Center, College of Medicine and Imperial College London explored how nerve cells repair themselves, which could lead to new treatments for nerve injuries.
A groundbreaking study using a tiny roundworm could pave the way for new treatments for neurodegenerative disorders. Researchers have linked the worm gene swip-10 to copper regulation – a vital element for brain health found in everyday items like wiring and cookware. Understanding the roles of swip-10 and MBLAC1, a protein involved in processing cellular materials, could lead to the development of effective medications and opens new avenues for advancing brain disease treatments.
Researchers at Washington University School of Medicine in St. Louis describe the dramatic changes within nerve cells that make regeneration possible. Such findings could inspire the development of new therapies for spinal cord injuries in people.
The coordinated activity of brain cells, like birds flying in formation, helps us behave intelligently in new situations, according to a study led by Cedars-Sinai investigators.
Harvard Medical School researchers are studying one of the most mysterious — and most essential — senses
Some children with autism thrive, while others require lifelong care. Now scientists know why — and the reason begins in the womb.
Australian scientists are exploring how harmful gut bacteria from a poor diet can access the brain and trigger early onset Alzheimer’s disease.
Dinosaurs were as smart as reptiles but not as intelligent as monkeys, as former research suggests.
Clever bio-inks that sit inside the human body and restore damaged neurons could cure a whole swathe of diseases in the next 20 years: conditions that have baffled scientists and clinicians for centuries.
Cedars-Sinai investigators have discovered how brain cells responsible for working memory—the type required to remember a phone number long enough to dial it—coordinate intentional focus and short-term storage of information.
The protein Asc-1 serves as the gateway (either for entry or exit) for fundamental amino acids involved in cognitive processes. A new study now unveils its structure and mechanism of action.
A group of researchers based at UC San Diego and Rady Children’s Institute have advanced the understanding of how the cerebral cortex develops by tracing the lineage of certain brain cells.
The typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle some of those bits and parts. That’s still the case, for the most part, but, Johns Hopkins Medicine researchers, studying nerve cells grown in the lab and mice, say that the proteasome’s role may go well beyond that.
Just as you can’t make an omelet without breaking eggs, scientists at Albert Einstein College of Medicine have found that you can’t make long-term memories without DNA damage and brain inflammation. Their surprising findings were published online today in the journal Nature.
For the first time, researchers from The University of Queensland (UQ) have mapped out the proteins implicated in the early stages of motor neurone disease (MND).
A study in fruit flies reveals how the brain’s compass and steering regions make course corrections
The discovery of a physical interaction between two proteins in brain cells that can be traced in mice to control of movement, anxiety and memory could one day open the door to development of new schizophrenia treatment strategies, researchers say.
Researchers at University of California San Diego School of Medicine have used single-cell sequencing to identify a potential new treatment for cocaine addiction and shed new light on the molecular underpinnings of addiction.
Immune system changes in the pregnant body that protect the fetus appear to extend to the brain, where a decrease in immune cells late in gestation may factor into the onset of maternal behavior, new research in rats suggests.
What makes the vital layer of protective cells around the brain and spinal cord — the blood-brain barrier — more or less permeable has been one of the more mystifying questions in neuroscience.
Researchers at Karolinska Institutet in Sweden have identified a group of nerve cells in the mouse brain that are involved in creating negative emotional states and chronic stress.
Researchers at The University of Queensland have discovered viruses such as SARS-CoV-2 can cause brain cells to fuse, initiating malfunctions that lead to chronic neurological symptoms.
According to a study published in Cell Reports, the tiny implantable devices formed stable, long-lasting and seamless tissue-electrode interfaces with minimal scarring or degradation in rodents.
A new study provides novel insight into the benefits of exercise, which should motivate adults to keep moving throughout their lifetime, especially during middle age. Long-term exercise profoundly benefits the aging brain and may prevent aging-related memory function decline by increasing the survival and modifying the network of the adult-born neurons born during early adulthood, and thereby facilitating their participation in cognitive processes.
UNC School of Medicine scientists demonstrated that stimulating a brain region called Supramammilary nucleus (SuM) located in the hypothalamus effectively enhanced adult-born neurons in the otherwise impaired Alzheimer’s brains of mice.
New research from Tufts University School of Medicine and the Graduate School of Biomedical Sciences suggests that the timing of the death of certain inhibitory neurons in the brain shortly after birth may be at least partly to blame for infantile spasms syndrome (ISS), a rare but devastating form of epilepsy that develops most frequently between four and eight months of age but can emerge within weeks of birth until ages 4 or 5.
Researchers discover a mechanism used by neurons to repair damage that occurs during neuronal activity
Scientists working in connectomics are creating comprehensive maps of how neurons connect to one another
A University of Minnesota Twin Cities researcher is part of an international team that has used two-photon imaging technology to show, for the first time, the creation and elimination of synapses between neurons in the brains of live mice.
Researchers find that the anesthetic and fast-acting antidepressant switches natural patterns of neuronal activity in the cortex of mice
Article title: Simultaneous whole-cell patch-clamp and calcium imaging on myenteric neurons Authors: Zhiling Li, Werend Boesmans, Youcef Kazwiny, Marlene M. Hao, Pieter Vanden Berghe From the authors: “Our findings will help in the interpretation of calcium imaging data without the…
Scientists at the Francis Crick Institute, UCL and the University of Edinburgh have uncovered how a build-up of harmful protein starts to happen within neurons in Parkinson’s disease, ultimately causing nerve cell death.
Researchers from Florida Atlantic University, in collaboration with Tel Aviv University, have received a two-year, $379,177 grant from the National Institute on Aging, National Institutes for Health, on a collaborative project to study mood-disorders changes in Alzheimer’s disease.
Research in mice reveals molecular mechanisms that underlie spatial mapping in the brain
Scientists at the Francis Crick Institute have identified a group of latent stem cells that respond to injury in the central nervous system of mice.
A historically overlooked rod-like projection present on nearly every cell type in the human body may finally be getting its scientific due: A new study has found that these appendages on neurons in the brain have a key role in ensuring a specific dopamine receptor’s signals are properly received.
In 1665, the Dutch scientist Christiaan Huygens hanged two of his recently invented pendulum clocks on a wooden beam and observed that as time passed, the clocks aligned their beats. Three and a half centuries later, neurons in the brain were found to sync their activities in a similar way.
On a quest to develop more effective pain medicines, scientists are studying how CBD inhibits pain-sensing neurons
Researchers at UC San Diego School of Medicine provide some of the first empirical evidence that brain ripples exist. These electrical waves have long been hypothesized as a way for the brain to integrate and encode memories.
A new study in mice describes how different cell types in the brain work together to suppress nausea
Scientists are starting to understand the precise workings of a type of gene that, unlike other genes, does not code for proteins – the building blocks of life.
Understanding how brain areas communicate is one of the oldest questions in neuroscience.
A team of researchers at the Case Western Reserve University School of Medicine believe they’ve found an answer to how thermal pain is sensed.
Researchers at the University of Tokyo have uncovered the molecular mechanism responsible for turning migratory actions on and off in nematode worms.
Scientists have long known that cocaine works by latching on to molecular connectors on the surface of brain cells, allowing dopamine, a chemical that promotes feelings of pleasure and reward, to accumulate in the space between brain cells. Now, Johns Hopkins Medicine scientists say they have found a molecular connector, known as the BASP1 receptor, that binds cocaine, even when the drug is present in very low doses.
Ketamine is the speedster of antidepressants, working within hours compared to more common antidepressants that can take several weeks. But ketamine can only be given for a limited amount of time because of its many side effects.
Researchers have long known that memory is represented by changes in the part of the brain called the hippocampus.
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