Drugs Effects of Ketamine in Mice can Depend on the Sex of the Human Experimenter

Researchers at the University of Maryland School of Medicine have shown that mice respond more to the antidepressant effects of the drug ketamine when administered by men and not by women. The group demonstrated that a stress response detected in the mouse’s brain from handling by a man is essential for ketamine to work.

UTSW-led research identifies new imaging biomarkers that predict antidepressant response

The outcome predictive models were developed in part using data from a large multi-center National Institute of Mental Health-funded study and published in the journal Biological Psychiatry. The findings provide strong evidence that the current trial-and-error approach used in clinical practice for the selection of the right antidepressant can be replaced with this new precision medicine approach.

No adverse cognitive effects of ketamine or esketamine for treatment-resistant depression

Used for the treatment of depression that does not respond to standard antidepressant medications, the anesthesia drug ketamine – and the related drug esketamine, recently approved for depression treatment – has no important adverse effects on memory, attention, or other cognitive processes, concludes a systematic review of medical research in the September/October issue of Harvard Review of Psychiatry. The journal is published in the Lippincott portfolio by Wolters Kluwer.

Study shows that while there is a link between maternal antidepressant use during pregnancy and affective disorders in the child later in life, the link also exists between paternal antidepressant use during pregnancy and child mental health; data su

Major depressive disorder is highly prevalent, with one in five people experiencing an episode at some point in their life, and is almost twice as common in women than in men.