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UrduIn two new papers, both published in Cell Reports Medicine, researchers from the University of Michigan Rogel Cancer Center describe the mechanisms of how alterations in the CDK12 gene drive prostate cancer development and report on a promising degrader that targets CDK12 and a related gene to destroy tumors.
Tag: Mouse Model
Improving Alzheimer’s disease imaging — with fluorescent sensors
Now, researchers in ACS Central Science demonstrate a way of packaging fluorescent sensors for easy passage across the blood-brain barrier in mice, allowing for improved brain imaging. With further development, the technology could help advance Alzheimer’s disease diagnosis and treatment.
UTHealth Houston researcher to present abstract detailing new mouse model for brain arteriovenous malformations at NIH meeting
An abstract unveiling a new mouse model for brain arteriovenous malformations (AVMs) developed by UTHealth Houston researchers has been selected for a poster presentation at the second annual National Institutes of Health (NIH) Investigator Meeting for Interoception Research in November.
CAR-T immune therapy attacks ovarian cancer in mice with a single dose
CAR-T immune therapies could be effective against solid tumors if the right targets are identified, a new study led by University of Illinois Urbana-Champaign researchers suggests. The researchers successfully deployed CAR-T in a mouse model of ovarian cancer, a type of aggressive, solid-tumor cancer that has eluded such therapies until now.
Study: Insect protein slows weight gain, boosts health status in obese mice
A new study in mice from the University of Illinois Urbana-Champaign suggests replacing traditional protein sources with mealworms in high-fat diets could slow weight gain, improve immune response, reduce inflammation, enhance energy metabolism, and beneficially alter the ratio of good to bad cholesterol.
New understanding of why kidney cancers become metastatic discovered by MD Anderson researchers
Researchers at The University of Texas MD Anderson Cancer have engineered a new model of aggressive renal cell carcinoma (RCC), highlighting molecular targets and genomic events that trigger chromosomal instability and drive metastatic progression.
The study, published today in Nature Cancer, demonstrates that the loss of a cluster of interferon receptor (IFNR) genes plays a pivotal role in allowing cancer cells to become tolerant of chromosomal instability. This genomic feature may be used to help clinicians predict a tumor’s potential to become metastatic and treatment resistant.
The Molecular Mechanism Behind Abdominal Aneurysms
In a new study using mice, University of Maryland School of Medicine researchers were able to tease apart the molecular components involved in abdominal aneurysms to better understand how and why they form.
Inhalable ‘SHIELD’ Protects Lungs Against COVID-19, Flu Viruses
Researchers have developed an inhalable powder that could protect lungs and airways from viral invasion by reinforcing the body’s own mucosal layer.
Injectable, radioactive gel synergizes with chemotherapy to shrink pancreatic tumors
NIBIB-funded researchers are developing a new method to treat pancreatic cancer. In their study, they combined an injectable radioactive gel with systemic chemotherapy in multiple mouse models of the disease. The treatment resulted in tumor regression in all evaluated models, an unprecedented result for this genetically diverse and aggressive type of cancer.
Unraveling the biology behind aggressive pediatric brain tumor reveals potential new treatment avenue
Researchers at the University of Michigan Rogel Cancer Center have identified a novel treatment approach to an aggressive type of pediatric brain cancer, using therapies already approved to treat cancer. The team developed a mouse model of pediatric glioma with a histone mutation called H3.3-G34, which allowed them to study the tumor’s biology in the presence of a functional immune system, revealing a promising outlook for long-term survival.
Drugs Effects of Ketamine in Mice can Depend on the Sex of the Human Experimenter
Researchers at the University of Maryland School of Medicine have shown that mice respond more to the antidepressant effects of the drug ketamine when administered by men and not by women. The group demonstrated that a stress response detected in the mouse’s brain from handling by a man is essential for ketamine to work.
Viral proteins key to tumor model in mice
A team of researchers at the University of Michigan Rogel Cancer Center were the first to generate a bona fide mouse model of a Merkel cell carcinoma, a rare and potentially aggressive form of skin cancer. The study outlining these results appeared in the Journal of Clinical Investigation.
Mouse model of transgender men finds active testosterone worsens IVF outcomes
Active testosterone therapy for transgender men may negatively impact IVF outcomes, suggests a mouse study being presented Monday at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga.
Neuroscientists identify how the brain links related memories
UCLA scientists have discovered how the brain links memories and a way to restore this function in aging mice–as well as an FDA-approved drug that achieves the same thing. The Nature findings suggest a new method for combatting middle-aged memory loss.
For psoriasis, targeting skin protein may help control inflammation
Targeting a protein found in the skin may reduce the severity of psoriasis, a Michigan Medicine study found. Using a mouse model to mimic psoriasis, researchers found changing levels of interferon kappa altered the severity of inflammation.
Mouse Model of COVID-19–induced Lung Injury May Aid Development of Coronavirus Treatments
Article title: The SARS-CoV-2 spike protein subunit 1 induces COVID-19–like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells Authors: Ruben Colunga Biancatelli, Pavel Solopov, Elizabeth R. Sharlow, John S. Lazo, Paul Ellis Marik, John…
Differences in human, mouse brain cells have important implications for disease research
A UCLA-led study comparing brain cells known as astrocytes in humans and mice found that mouse astrocytes are more resilient to oxidative stress, a damaging imbalance that is a mechanism behind many neurological disorders.
LJI and Synbal, Inc. partner to develop better COVID-19 models
The La Jolla Institute for Immunology (LJI) is partnering with Synbal, Inc., a preclinical biotechnology company based in San Diego, CA, to develop multi-gene, humanized mouse models for COVID-19 research. The research at LJI will be led by Professor Sujan Shresta, Ph.D., a member of the Institute’s Center for Infectious Disease and Vaccine Research.
New Mouse Line Leads to Noninvasive Study of Mitochondrial Calcium Signaling
New research published ahead of print in the journal Function explores the creation of a new transgenic mouse line that allows for noninvasive study of calcium signaling in the mitochondria—the energy-releasing “powerhouse” of cells. The new mouse line, called ROSA26-mt-Cam,…
Iowa and Ohio Researchers Discover New, Protective Strategy for Embryonic Development during Prenatal Stress in Animal Model
New research from the University of Iowa and University Hospitals Cleveland Medical Center demonstrates that offspring can be protected from the effects of prenatal stress by administering a neuroprotective compound during pregnancy.
Research News Tip Sheet: Story Ideas From Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Tuesday.
Genetic rescue of SHANK3 is potential therapy in rare forms of autism spectrum disorder
A mouse study by Craig Powell, M.D., Ph.D., and colleagues suggests that early genetic rescue may be a potential therapy in autism spectrum disorder, or ASD. Powell looked at one gene called SHANK3, whose alteration is seen in about 0.5 percent of ASD patients.
COVID-19 mouse model will speed search for drugs, vaccines
Researchers at Washington University School of Medicine in St. Louis have developed a mouse model of COVID-19 that is expected to speed up the search for drugs and vaccines for the potentially deadly disease.
Inhalation Therapy Shows Promise Against Pulmonary Fibrosis in Mice, Rats
A new study shows that lung stem cell secretions – specifically exosomes and secretomes – delivered via nebulizer, can help repair lung injuries due to multiple types of pulmonary fibrosis in mice and rats.
Cyp2F2-Mediated Lung Cancer, Rapid Risk Assessment of Color Additives, and More Featured in November 2019 Toxicological Sciences
Toxicological Sciences continues to deliver cutting-edge research in toxicology in the November 2019 issue. This issue features research on computational toxicology and databases, developmental and reproductive toxicology, and more.
Of Mice And Babies: New Animal Model Links Blood Transfusions to Dangerous Digestive Disease in Preemies
Physicians have long suspected that red blood cell transfusions given to premature infants with anemia may put them in danger of developing necrotizing enterocolitis, a potentially lethal inflammatory disease of the intestines. However, solid evidence for the connection has been difficult to obtain in part because of the lack of a practical animal model able to accurately represent what physically occurs when a baby gets NEC.