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UrduRutgers researchers find long-term users of cocaine may continue with unrewarding behavior because of changes in brain structure and chemistry responsible for generating an important teaching signal.
Tag: Cocaine Addiction
Cellular Atlas of Amygdala Reveals New Treatment Target for Cocaine Addiction
Researchers at University of California San Diego School of Medicine have used single-cell sequencing to identify a potential new treatment for cocaine addiction and shed new light on the molecular underpinnings of addiction.
New study reveals ketamine could be effective treatment for cocaine-use disorders
As cocaine use continues to climb across the United States, scientists have struggled to develop an effective pharmacological approach to treat the devastating disorder. But by seamlessly combining artificial intelligence (AI), human intelligence, clinical testing and computer analysis, researchers at Case Western Reserve University have unearthed an existing option that appears to hold promise.
Cocaine addiction makes the brain age faster, suggests study
A new study finds evidence from the DNA methylome that the biological age – different from the chronological age – of cells in Brodmann Area 9 of the prefrontal cortex might be greater in people with cocaine use disorder. This suggests that cocaine abuse makes these cells age faster according to the ‘epigenetic clock’. The authors also find differences in methylation in 20 genes, mainly involved in regulation of the activity of neurons and their connectivity. This post-mortem study is one of the first to directly look at the methylome of brain cells in human donors with cocaine use disorder, rather than in rodents.
Cocaine Use Disorder Alters Gene Networks of Neuroinflammation and Neurotransmission in Humans
Analysis reveals similar changes in the brain’s functioning in both humans and mouse models
Brain-gut connection may reveal way to prevent cocaine addiction
Cocaine disrupts the balance of microbes in the guts of mice, part of a cycle of waxing and waning neurochemicals that can enhance the drug’s effects in the brain. But the same chemicals may also be harnessed to prevent addiction, according to new research from the University of Wisconsin–Madison.Cocaine increases levels of a hormone called norepinephrine in users’ intestines, triggering an explosion of growth of proteobacteria, a family of microbes that includes the common and sometimes harmful bacterium E.
Human Cocaine and Heroin Addiction Is Found Tied to Impairments in Specific Brain Circuit Initially Implicated in Animals
Study results suggest the pre-frontal cortex-habenula circuit is potentially amenable for targeted interventions and prevention.
As Cocaine Overdose Deaths Increase, New Study @UCSDMedSchool Offers Potential Cocaine Addiction Treatment
Robert Anthenelli, MD, professor and director, Pacific Treatment and Research Center, UC San Diego School of Medicine, is available to talk about a new study that is investigating the potential use of a novel medication for cocaine addiction. UC San…
A Technique for Regulating Emotion May be Effective in Disrupting Compulsive Cocaine Addiction, a Mount Sinai Study Has Found
An emotion regulation strategy known as cognitive reappraisal helped reduce the typically heightened and habitual attention to drug-related cues and contexts in cocaine-addicted individuals, a study by Mount Sinai researchers has found.