Researchers find that CRY-1, a regulator of circadian rhythms, promotes tumor progression by altering DNA repair.Read more
Our DNA acts like a book of recipes for making proteins. But if a recipe is wrong, what does a cell do Peng Mao, PhD, and his team discovered an intricate series of events that cells use to repair our DNA as the recipes are being read. Their findings could lead to improved cancer treatments.Read more
A study finds that cancer mutations occur in distinct patterns based on the 3D structure of the genome and the underlying cause of the mutation. This helps us to understand cancer better and may lead to new treatment approaches.
Proofreading proteins prevent DNA replication errors by creating an immobile structure that calls more proteins to the site to repair the error. This structure could also prevent the mismatched region from being “packed” back into the cell during division.Read more
Researchers from Harvard University and the University of Texas Medical Branch at Galveston recently used the Comet supercomputer at the San Diego Supercomputer Center (SDSC) at the University of California San Diego to uncover the novel ways in which DNA prepares itself for repair.Read more
In a series of experiments using human cancer cell lines, scientists at Johns Hopkins Medicine say they have successfully used light as a trigger to make precise cuts in genomic material rapidly, using a molecular scalpel known as CRISPR, and observe how specialized cell proteins repair the exact spot where the gene was cut.Read more
Yale Cancer Center scientists have identified mutations in metabolite-producing genes as a disruption of DNA repair. These mutation-driven “oncometabolites” may make cells more prone to developing cancer—but also more vulnerable to new cancer treatment strategies.Read more
Upon exposure to human skin, ultraviolet light from the sun almost instantly generates two types of “lesions” that damage DNA. Scientists at UW Medicine in Seattle determined which of these lesions is responsible for activating a process that may increase cancerous mutations in cells.Read more