Researchers at The University of Texas MD Anderson Cancer Center have discovered that a protein called NF-kappa B-inducing kinase (NIK) is essential for the shift in metabolic activity that occurs with T cell activation, making it a critical factor in regulating the anti-tumor immune response.
Yale Cancer Center scientists have identified mutations in metabolite-producing genes as a disruption of DNA repair. These mutation-driven “oncometabolites” may make cells more prone to developing cancer—but also more vulnerable to new cancer treatment strategies.
A Roswell Park team has identified a new strategy for treating prostate cancer — the first to target metabolic processes uniquely important to prostate cancer.
Cancer-fighting compound fights obesity and diabetes: Eric Prossnitz, PhD, and his team reported that G-1, a cancer-fighting compound they discovered some years ago, reduces fat in obese mice. Although G-1 is currently in phase 1 clinical trials for cancer, Prossnitz and his team are planning preclinical studies to use G-1 to fight fat in obese people.
A new screening system developed by scientists at the UCLA Jonsson Comprehensive Cancer Center leverages redundancy in an important component of a cell – nucleotide metabolism – to help identify new drugs that specifically and potently block processes that are essential for cancer cell growth.
Recent study found that an effective blood cancer treatment was associated with weight gain, obesity, and increased systolic blood pressure
This fall, the Morgridge Institute for Research will convene international leaders in metabolic research at the third Frontiers in Metabolism—Mechanisms of Metabolic Diseases meeting. Disrupted metabolic processes underlie a broad swath of rare inborn errors of metabolism and prominent human…