Collaborative and creative policies needed to maximize psychedelics’ therapeutic potential

Research supports the promise of psychedelics in treating conditions like depression and post-traumatic stress disorder, but the future regulatory landscape for these drugs remains unclear. Experts from Baylor College of Medicine, the University of Pennsylvania, American University and Harvard Law School call for creativity and collaboration at the federal and state levels in developing policies for the use and oversight of psychedelics and a commitment to developing a strong evidence base for efficacy and safety.

Over half of top selling Medicare drugs have low added therapeutic benefit

Brand-name drugs cost two to three times more in the U.S. than in other countries, but many of the top-selling brand name drugs may provide little added therapeutic benefit. A new study led by researchers at Brigham and Women’s Hospital, a founding member of Mass General Brigham, used public Medicare data to identify the 50 highest-selling brand-name drugs in 2020.

Degrading modified proteins could treat Alzheimer’s, other ‘undruggable’ diseases

A new technique that targets and breaks apart certain proteins — rather than just interfering with them — may offer a pathway toward treatment of Alzheimer’s disease. Researchers reporting in ACS Central Science have designed a compound that breaks down a protein closely associated with the disease.