EMS Ketamine Use on Agitated Patients on Cocaine Increases Intubation 5.75-fold

Patients with excited delirium often are administered ketamine by EMS before arriving at the hospital. Many of them are intoxicated or are using illicit substances, which may alter the properties of ketamine.

Novel Anti-Craving Mechanism Discovered to Treat Cocaine Relapse

Cocaine continues to be one of the most commonly abused illicit drugs in the United States. Pre-clinical literature suggests that targeting glucagon-like peptide-1 receptors (GLP-1Rs) in the brain may represent a novel approach to treating cocaine use disorder. Specifically, GLP-1R agonists, which are FDA-approved for treating diabetes and obesity, have been shown to reduce voluntary drug taking and seeking in preclinical models of cocaine used disorder. However, the exact neural circuits and cell types that mediate the suppressive effects of GLP-1R agonists on cocaine-seeking behavior are mostly unknown.