Data show that concurrent with the opioid overdose crisis, there has been an increase in hospitalizations of people with opioid use disorder (OUD). One in ten of these hospitalized medical or surgical patients have comorbid opioid-related diagnoses.
Tag: Heath Schmidt
Novel Anti-Craving Mechanism Discovered to Treat Cocaine Relapse
Cocaine continues to be one of the most commonly abused illicit drugs in the United States. Pre-clinical literature suggests that targeting glucagon-like peptide-1 receptors (GLP-1Rs) in the brain may represent a novel approach to treating cocaine use disorder. Specifically, GLP-1R agonists, which are FDA-approved for treating diabetes and obesity, have been shown to reduce voluntary drug taking and seeking in preclinical models of cocaine used disorder. However, the exact neural circuits and cell types that mediate the suppressive effects of GLP-1R agonists on cocaine-seeking behavior are mostly unknown.