Overdose deaths from fentanyl laced stimulants have risen 50-fold since 2010

New UCLA-led research has found that the proportion of US overdose deaths involving both fentanyl and stimulants has increased more than 50-fold since 2010, from 0.6% (235 deaths) in 2010 to 32.3% (34,429 deaths) in 2021. This rise in constitutes the ‘fourth wave’ in the US’s long-running opioid overdose crisis

How AI Can Help Design Drugs to Treat Opioid Addiction

ROCKVILLE, MD – Approximately three million Americans suffer from opioid use disorder, and every year more than 80,000 Americans die from overdoses. Opioid drugs, such as heroin, fentanyl, oxycodone and morphine, activate opioid receptors. Activating mu-opioid receptors leads to pain relief and euphoria, but also physical dependence and decreased breathing, the latter leading to death in the case of drug overdose.

Human Cocaine and Heroin Addiction Is Found Tied to Impairments in Specific Brain Circuit Initially Implicated in Animals

Study results suggest the pre-frontal cortex-habenula circuit is potentially amenable for targeted interventions and prevention.

Real-time opioid overdose tracking system shows rise in the time of COVID-19

An epidemic that was already raging before COVID-19 arrived has flared up in recent months, according to a real-time tracking system in Michigan. It shows a 15 percent rise in suspected opioid overdose deaths since March, compared with the same time last year, and a 29% rise in first responders’ use of the rescue drug naloxone.

Large majority of state’s heroin users want to reduce use; syringe programs helping during COVID-19 crisis

A new survey of people who inject illicit drugs in the state of Washington yields positive and important findings for policy makers as the world struggles to deal with the COVID-19 pandemic, said authors of the survey by the University of Washington and Public Health-Seattle & King County.

Regional trends in overdose deaths reveal multiple opioid epidemics, according to new study

A recently published study shows the United States in the grip of several simultaneously occurring opioid epidemics, rather than just a single crisis. The epidemics came to light after the researchers analyzed county-level data on drug overdose deaths. The study highlights the importance of different policy responses to the epidemics rather than a single set of policies.