Bristol-led research has identified specific drug targets within the neural circuits that encode memories, paving the way for significant advances in the treatment of a broad spectrum of brain disorders.
Researchers at the Icahn School of Medicine at Mount Sinai found that a tool commonly used in research for evaluating a person’s genetic risk for a disease, called a polygenic risk score, was no better at predicting the outcome of a schizophrenia patient’s disease over time than written reports. The results raise important questions about the use of polygenic risk scores in real-world, clinical situations, and also suggest that a doctor’s written report may be an untapped source of predictive information.
Scientists at Sanford Burnham Prebys have discovered how levels of a protein could be used in the future as a blood-based diagnostic aid for schizophrenia.
UC San Diego researchers report that medications commonly prescribed to reduce the severity of physical and mental health symptoms associated with schizophrenia may have a cumulative effect of worsening cognitive function in patients.
A person with a serious mental illness must confront the difficult decision of whether to reveal their disorder in their workplace. Disclosing their diagnosis might create stigma, but it could also mean additional support. Adding to the delicate balancing act…
Subtle differences in the shape of the brain that are present in adolescence are associated with the development of psychosis, according to an international team led by psychiatrists at the University of Pittsburgh School of Medicine and Maastricht University in the Netherlands.
A computer game that induces mice to experience hallucination-like events could be a key to understanding the neurobiological roots of psychosis, according to a study from Washington University School of Medicine in St. Louis.
A pilot study has found evidence of Bartonella infection in the blood of people with schizophrenia and schizoaffective disorder.
Dropping out of high school, having schizophrenia, or being diagnosed with a co-occurring personality disorder increases the likelihood of someone becoming a “high utilizer” of inpatient psychiatric hospital services, according to a new study by researchers at UTHealth. A high utilizer is someone who has been admitted three or more times within one year.
Dror Ben-Zeev, a professor of psychiatry and behavioral sciences at the University of Washington’s School of Medicine, is an expert on mental health apps. He is a licensed clinical psychologist who specializes in technology-based approaches in the study, assessment, and…
Digital mental health apps and internet-based treatments could overcome both access problems and provider shortages. But these apps have yet to be adopted in the U.S. healthcare system. One reason is that these apps need payment and reimbursement models that would enable broad adoption.
Researchers at the University of Washington School of Medicine recently published results to help propel policymakers to create these payment models. They proved that an app to help people with serious mental illness was just as effective as a clinic-based group intervention for half the cost.
A research team at the Fralin Biomedical Research Institute at VTC has identified the type of brain cell that produces a protein that is crucial for the formation of inhibitory circuits in the brain. This insight could one day help scientists establish the basis for developing new drugs that mature or repair cellular networks.
Although schizophrenia is increasingly understood as a neurodevelopmental disorder, environmental factors are known to play an important role in the disease onset and progression.
Jerold Chun, M.D., Ph.D., a professor and senior vice president at Sanford Burnham Prebys Medical Discovery Institute, has been named a “Highly Cited Researcher” by Clarivate, the global analytics company. The honor recognizes researchers who have demonstrated a significant influence in their chosen field of study through the publication of multiple works that have been cited by their peers.
FINDINGS UCLA scientists and colleagues found the use of long-acting antipsychotic medication combined with the use of cognitive training in group settings led to improved cognition and increased productivity. Researchers say patients using a combination of long-acting antipsychotic medication and…
UCLA researchers and their colleagues from two other institutions have been awarded a $52 million grant from the National Institutes of Health to lead an international study to better understand the cause and effect of schizophrenia in high-risk youth.
Study shows long-lasting effects and points the way to potential treatments
Zafiris J. “Jeff” Daskalakis, MD, PhD, has been named chair of the Department of Psychiatry at University of California San Diego School of Medicine.
Variants in a gene of the human immune system cause men and women to have different vulnerabilities to the autoimmune diseases lupus and Sjögren’s syndrome, according to findings published in the journal Nature. The gene variants are a member of the complement system.
A recent conceptual development in schizophrenia is to view its manifestations as interactive networks rather than individual symptoms. Negative symptoms, which are associated with poor functional outcome and reduced rates of recovery, represent a critical need in schizophrenia therapeutics. MIN101…
MEDIA ADVISORY Nature Communications study UNDER EMBARGO UNTIL: Friday, February 21 at 5:00pm EST Mount Sinai Researchers find social isolation during key developmental windows drives long term changes to activity patterns of neurons involved in initiating social approach in an…
UCLA researchers have found that it is possible to assess a person’s ability to feel empathy by studying their brain activity while they are resting rather than while they are engaged in specific tasks.
Scientists at St. Jude Children’s Research Hospital have implicated two microRNAs in the biological processes that underlie the ventricle enlargement observed in models of schizophrenia.
Thanks largely to advances in computing, researchers in computational biology and data science are harnessing the power of the masses and making discoveries that provide valuable insights into human health.
The promise of flickering light to treat Alzheimer’s takes another step forward in this new study, which reveals stark biochemical mechanisms: The 40 Hertz stimulation triggers a marked release of signaling chemicals.
“Bipolar disorder and schizophrenia, and many other types of mental illness, are diseases of the brain and should be treated and studied as such,” say Johns Hopkins researchers.
A new study finds that an interactive voice application using artificial intelligence is as accurate at tracking the wellbeing of patients being treated for serious mental illness as their physicians.
A molecular switch has the ability to turn on a substance in animals that repairs neurological damage in disorders such as multiple sclerosis (MS), Mayo Clinic researchers discovered.
Ever since humans domesticated the dog, the faithful, obedient and protective animal has provided its owner with companionship and emotional well-being. Now, a study from Johns Hopkins Medicine suggests that being around “man’s best friend” from an early age may have a health benefit as well — lessening the chance of developing schizophrenia as an adult.
A new study led by researchers at the University of North Carolina at Chapel Hill has found that that using a polygenic risk score (PRS) based on data from genome-wide association studies (GWAS) improves psychosis risk prediction in persons meeting clinical high-risk criteria.
Animal models can serve as gateways for understanding many human communication disorders, but a new study from the University at Buffalo suggests that the established practice of socially isolating mice for such purposes might actually make them poor research models for humans, and a simple shift to a more realistic social environment could greatly improve the utility of the future studies.
Schizophrenia findings revealed by team from UNR School of Medicine, UM School of Dentistry, who colllaborated with British and Turkish investigators
A new study finds that adults with cerebral palsy are at an increased risk of experiencing a mental health disorder compared to adults without the condition.
Findings suggest a form of schizophrenia has more in common with neurodegenerative diseases than previously thought In a study using brain tissue from deceased human donors, Johns Hopkins Medicine researchers say they found new evidence that schizophrenia can be marked…