English
Arabic
Chinese (Simplified)
Dutch
Esperanto
French
German
Greek
Italian
Japanese
Korean
Portuguese
Russian
Spanish
UrduMicrobes have enormous potential to produce metabolites with potential industrial applications. To do so, microbes use groups of genes called biosynthetic gene clusters (BGCs) that code for the sets of necessary enzymes. Scientists have computationally predicted the products of hundreds of thousands of BGCs, but have experimentally confirmed fewer than 2,000 of them. Researchers have now developed a computational and experimental strategy to redesign BGCs and determine the natural chemical products they create.
Tag: Metabolites
Cheese experiments show fungal antibiotics can influence microbiome development
In a new study, researchers use cheese rinds to demonstrate that fungal antibiotics can influence how microbiomes develop.
Using fungi, researchers convert ocean plastic into ingredients for drug industry
Research on fungi underway at the University of Kansas has helped transform tough-to-recycle plastic waste from the Pacific Ocean into key components for making pharmaceuticals.
Evidence Map of Gut Metabolites Identifies Links to Cancer, Digestive Disorders
Review of over 300 studies sifts out relationships between metabolites and health worth a further look.
Scientists use machine learning to get an unprecedented view of small molecules
A new tool to identify small molecules offers benefits for diagnostics, drug discovery, and fundamental research.
Blood-based metabolic signature outperforms standard method for predicting diet, disease risk
Researchers have found a method using molecular profiling and machine learning to develop blood-based dietary signatures that more accurately predict both diet and the risk of cardiovascular disease and type 2 diabetes. They say the metabolic snapshot could allow those studying food science to better understand the implications of diet and nutrition on health.
Innovative Self-Powered Ingestible Sensor Opens New Avenues for Gut Research
Engineers developed a battery-free, pill-shaped ingestible biosensing system that gives scientists the ability to monitor gut metabolites in real time, which wasn’t possible before. The work could lead to a new understanding of intestinal metabolite composition, which significantly impacts human health.
Study Examines the Impact of Coral Chemical Compounds on Reef Composition and Health
Stumbling upon a new source of underwater caffeine was just an added bonus of a new study examining the impact of chemical compounds that corals release into the seawater.
Five Minutes of Daily Breath Training Improves Exercise Tolerance in Middle-aged and Older Adults
New research finds potential for high-resistance inspiratory muscle strength training to help sedentary middle-aged and older adults transition to a healthier lifestyle. The study will be presented this week at the American Physiological Society annual meeting at Experimental Biology 2022.
Cleveland Clinic Study Links Gut Microbiome and Aggressive Prostate Cancer
Cleveland Clinic researchers have shown for the first time that diet-associated molecules in the gut are associated with aggressive prostate cancer, suggesting dietary interventions may help reduce risk. Findings from the study were published in Cancer Epidemiology, Biomarkers & Prevention.
Labeling the Thale Cress Metabolites
: Plants synthesize thousands of metabolites that help them adapt to their environments. Mass spectrometry can detect and measure metabolites in a sample, but this is difficult with complex samples. One solution is to add labeled chemicals to a sample. This research developed an easy-to-use computational tool that locates labeled chemicals, simplifying analysis.
Cancer has ripple effect on distant tissues
A new study with zebrafish shows that a deadly form of skin cancer — melanoma — alters the metabolism of healthy tissues elsewhere in the body. The research from Washington University in St. Louis suggests that these other tissues could potentially be targeted to help treat cancer.“Tumors rely on a constant supply of nutrients to grow.
Rutgers Professor Joan Bennett Elected to American Academy of Arts & Sciences
Joan W. Bennett, a Distinguished Professor of plant biology and pathology at Rutgers University–New Brunswick, has been elected to the American Academy of Arts & Sciences. She joins neurosurgeon and CNN medical correspondent Sanjay Gupta, NASA’s Goddard Space Flight Center atmospheric scientist Ann Thompson and media entrepreneur and philanthropist Oprah Winfrey.
Studying Metabolic Regulation Through Cellular Properties
During cellular metabolism, enzymes break down and build fats, proteins, energy carriers, and genetic information. These processes happen through a complex network of reactions. Until now, studies to identify specific reactions that regulate the overall flow through a network were too complex to do regularly. Now scientists have developed new methods that combine cutting-edge techniques to predict which enzymes control common biochemical pathways.
Bile acids may play previously unknown role in Parkinson’s
GRAND RAPIDS, Mich. (Feb. 2, 2021) — What does bile acid production in the digestive tract have to do with Parkinson’s disease?
Drug-Induced Liver Injury, Translational microRNA Biomarkers, and More Featured in January 2021 Toxicological Sciences
in the January 2021 issue, Toxicological Sciences offers an engaging slate of research in toxicology, from endocrine toxicology and biomarkers to genetic and epigenetic toxicology and mixtures toxicology.
Metabolism May Play Role in Recurrent Major Depression
Researchers at UC San Diego School of Medicine, in collaboration with Dutch scientists, have found that certain metabolites — small molecules produced by the process of metabolism — may be predictive indicators for persons at risk for recurrent major depressive disorder.
How to Identify Heat-Stressed Corals
Researchers have found a novel way to identify heat-stressed corals, which could help scientists pinpoint the coral species that need protection from warming ocean waters linked to climate change, according to a Rutgers-led study.
Detection of Blood Transfusion
Autologous blood transfusion is performance enhancing, and detection of abuse remains a major challenge in sports. To address this issue, investigators transfused a group of men with either blood or saline, and evaluated whether metabolites collected in urine before and…
Sweat science: engineers detect health markers in thread-based, wearable sweat sensors
Engineers at Tufts University have created a first-of-its-kind, flexible electronic sensing patch that can be sewn into clothing to analyze sweat for multiple markers. The patch could be used to to diagnose and monitor acute and chronic health conditions or to monitor athletic performance.
Aspirin, flavonoid metabolites may be preventing colorectal cancer
Simpler phenolic compounds, known as hydroxybenzoic acids, that result when the gut bacteria break down aspirin and flavonoids from fruits and vegetables may contribute to colorectal cancer prevention.
Metabolite Analysis of ALS Patient Blood Plasma Could Reveal, Rule Out, Possible Biomarkers for Disease
High-throughput analysis of blood plasma could aid in identification of diagnostic and prognostic biomarkers for amyotrophic lateral sclerosis (ALS).
Identifying the Dark Matter of the Molecular World
Scientists have deployed artificial intelligence to identify more of the billions of metabolites that are currently unknown. The small molecules underlie and inform every aspect of our lives, including energy production, the fate of the planet, and our health. “Beast Mode” helps explain how they did it.
Serum Biomarkers, Metabolite Indicators for Kidney Toxicity, Estrogenic Compound Screening, and More Featured in February 2020 Toxicological Sciences
The February 2020 issue of Toxicological Sciences includes cutting-edge research spanning the toxicological field, from molecular, biochemical, and systems toxicology and nanotoxicology to regulatory science, risk assessment, and decision-making.