: Plants synthesize thousands of metabolites that help them adapt to their environments. Mass spectrometry can detect and measure metabolites in a sample, but this is difficult with complex samples. One solution is to add labeled chemicals to a sample. This research developed an easy-to-use computational tool that locates labeled chemicals, simplifying analysis.
A new study with zebrafish shows that a deadly form of skin cancer — melanoma — alters the metabolism of healthy tissues elsewhere in the body. The research from Washington University in St. Louis suggests that these other tissues could potentially be targeted to help treat cancer.“Tumors rely on a constant supply of nutrients to grow.
Joan W. Bennett, a Distinguished Professor of plant biology and pathology at Rutgers University–New Brunswick, has been elected to the American Academy of Arts & Sciences. She joins neurosurgeon and CNN medical correspondent Sanjay Gupta, NASA’s Goddard Space Flight Center atmospheric scientist Ann Thompson and media entrepreneur and philanthropist Oprah Winfrey.
During cellular metabolism, enzymes break down and build fats, proteins, energy carriers, and genetic information. These processes happen through a complex network of reactions. Until now, studies to identify specific reactions that regulate the overall flow through a network were too complex to do regularly. Now scientists have developed new methods that combine cutting-edge techniques to predict which enzymes control common biochemical pathways.
GRAND RAPIDS, Mich. (Feb. 2, 2021) — What does bile acid production in the digestive tract have to do with Parkinson’s disease?
in the January 2021 issue, Toxicological Sciences offers an engaging slate of research in toxicology, from endocrine toxicology and biomarkers to genetic and epigenetic toxicology and mixtures toxicology.
Researchers at UC San Diego School of Medicine, in collaboration with Dutch scientists, have found that certain metabolites — small molecules produced by the process of metabolism — may be predictive indicators for persons at risk for recurrent major depressive disorder.
Researchers have found a novel way to identify heat-stressed corals, which could help scientists pinpoint the coral species that need protection from warming ocean waters linked to climate change, according to a Rutgers-led study.
Autologous blood transfusion is performance enhancing, and detection of abuse remains a major challenge in sports. To address this issue, investigators transfused a group of men with either blood or saline, and evaluated whether metabolites collected in urine before and…
Engineers at Tufts University have created a first-of-its-kind, flexible electronic sensing patch that can be sewn into clothing to analyze sweat for multiple markers. The patch could be used to to diagnose and monitor acute and chronic health conditions or to monitor athletic performance.
Simpler phenolic compounds, known as hydroxybenzoic acids, that result when the gut bacteria break down aspirin and flavonoids from fruits and vegetables may contribute to colorectal cancer prevention.
High-throughput analysis of blood plasma could aid in identification of diagnostic and prognostic biomarkers for amyotrophic lateral sclerosis (ALS).
Scientists have deployed artificial intelligence to identify more of the billions of metabolites that are currently unknown. The small molecules underlie and inform every aspect of our lives, including energy production, the fate of the planet, and our health. “Beast Mode” helps explain how they did it.
The February 2020 issue of Toxicological Sciences includes cutting-edge research spanning the toxicological field, from molecular, biochemical, and systems toxicology and nanotoxicology to regulatory science, risk assessment, and decision-making.