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UrduBACKGROUNDHuman induced pluripotent stem cell (hiPSC) technology is a valuable tool for generating patient-specific stem cells, facilitating disease modeling, and investigating disease mechanisms. However, iPSCs carrying specific mutations
Tag: Proteomics
First Steps Toward a Whole-Body Map of Molecular Responses to Exercise
PNNL contributes to a nationwide research consortium investigating the molecular mechanisms triggered by endurance training.
Researchers Characterize the Immune Landscape in Cancer
Researchers from the Icahn School of Medicine at Mount Sinai, in collaboration with the Clinical Proteomic Tumor Analysis Consortium of the National Institutes of Health, The University of Texas MD Anderson Cancer Center, Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and others, have unveiled a detailed understanding of immune responses in cancer, marking a significant development in the field. The findings were published in the February 14 online issue of Cell. Utilizing data from more than 1,000 tumors across 10 different cancers, the study is the first to integrate DNA, RNA, and proteomics (the study of proteins), revealing the complex interplay of immune cells in tumors. The data came from the Clinical Proteomic Tumor Analysis Consortium (CPTAC), a program under the National Cancer Institute.
Clues to cancer drug’s deadly side effects could make it safer
For some leukemia patients, their only treatment option carries a risk of heart failure
Making gluten-free, sorghum-based beers easier to brew and enjoy
Beer is usually made from barley, leaving those with a gluten allergy unable to enjoy. Sorghum could be an alternative, but complex preparation steps hamper its adoption. A team reporting in ACS’ Journal of Proteome Research has uncovered an enzyme that could improve sorghum-based beers’ future.
Submit proposal for research funding opportunity at EMSL, a Department of Energy scientific facility
The Environmental Molecular Sciences Laboratory (EMSL) is seeking biological and environmental science project proposals for the Fiscal Year 2024 Exploratory Research Call through 5 p.m. on Thursday, July 6.
When Water Temperatures Change, the Molecular Motors of Cephalopods Do Too
Working with live squid hatchlings at Scripps Institution of Oceanography, UC San Diego scientists find the animals can tune their proteome on the fly in response to changes in ocean temperature via the unique process of RNA recoding. The findings inspire new questions about basic protein function.
Researchers Target Proteins, Pathways Behind Congenital Heart Disease
The research provides scientists with much-needed information to identify biological causes for congenital heart disease, or CHD.
Harmful Effects of Long-Term Alcohol Use Documented in Blood Protein Snapshot
A detailed snapshot of proteins by PNNL scientists marks a big step toward a diagnostic blood test for a deadly form of liver disease – alcohol-associated hepatitis.
New Look at an Ancient Disease: Study Finds Novel Treatment Targets for Gout
UC San Diego scientists identify a new molecular model and potential therapeutic target for gout, the most common form of inflammatory arthritis.
Big Data Analysis Powers the Fight Against Alzheimer’s
New research findings published in Science Advances (November 2022), help explain the progression of Alzheimer-related dementia in each patient. The findings outline a biological classification system that predicts disease severity.
UCSF Awarded $67.5 Million to Develop New Antiviral Therapies
Scientists at the UC San Francisco (UCSF) Quantitative Biosciences Institute (QBI) and the QBI Coronavirus Research Group (QCRG) have been awarded $67.5 million from the National Institute of Allergy and Infectious Diseases (NIAID) to support its mission of pandemic preparedness.
E-cigarettes Stress Lungs, Impair Protein Function
E-cigarette exposure stresses and inflames the lungs of rats, compromising important quality control proteins, according to new research.
Large-scale cancer proteomics study profiles protein changes in response to drug treatments
Through large-scale profiling of protein changes in response to drug treatments in cancer cell lines, researchers at The University of Texas MD Anderson Cancer Center have generated a valuable resource to aid in predicting drug sensitivity, to understand therapeutic resistance mechanisms and to identify optimal combination treatment strategies.
J. Silvio Gutkind, PhD, Named Chair of the Department of Pharmacology
J. Silvio Gutkind, PhD, has been named chair of the Department of Pharmacology at UC San Diego School of Medicine.
Crippling Life Support for SARS-CoV-2 Through Synthetic Lethality
Significance of paperThis paper authored by a group of scientists from the Center for Global Infectious Disease Research at Seattle Children’s Research Institute presents a promising concept for disrupting the life cycle of a virus using synthetic lethality. When viruses infect…
Combining Omics, Function and Phenotype Brings New Insight to Kidney Function and Physiology
Researchers use a novel integrative approach to examine function and proteins expressed by a highly specialized segment of the kidneys in a new study published ahead of print in the journal Function. Current technology makes it possible to analyze molecules…
Argonne’s researchers and facilities playing a key role in the fight against COVID-19
Argonne scientists are working around the clock to analyze the virus to find new treatments and cures, predict how it will propagate through the population, and make sure that our supply chains remain intact.
New, Detailed Molecular Roadmap Boosts Fight Against Endometrial Cancer
Scientists have taken an unprecedented look at proteins involved in endometrial cancer, commonly known as uterine cancer. The study offers insights about which patients will need aggressive treatment and which won’t, and offers clues about why a common cancer treatment is not effective with some patients.